A Study On Topical Nanoemulsion Based Gel Of Terbinafine H Cl

1055 words - 5 pages

Objective: The objective of the present study was to design topical Nanoemulsion based gel of Terbinafine HCl, a poorly soluble drug, to increase its permeability and evaluate its efficacy in an animal model.
Materials and Methods: Nanoemulsions were incorporated into gels and designated as Gel-P and Gel-S respectively. Nanoemulsion gel was prepared using liquid paraffin, glycerin, and carbomer 940. Nanoemulsions were prepared by two different techniques viz. high pressure homogenization and high speed homogenization. The developed gels were evaluated for drug content, spreadability, microbial assay and in vitro permeation using pork skin. The in vivo antifungal efficacy of the developed gels was assessed in albino Wistar rats.
Results and Discussion: The globule size obtained by high pressure homogenization was less than 2 r.nm (nanometer in radius) and that by high speed homogenization was less than 10 r.nm. In vitro permeation studies revealed that Gel-P (51.19±0.81 %) had higher permeation when compared to Gel-S (31.72±1.12 %) and marketed cream (19.78±1.01 %) which is essential to treat topical fungal diseases. In vivo antifungal studies in Wistar rats infected with Trichophyton mentagrophytes revealed that topical application of Gel P and Gel S cured the infection within 3 d compared to 14 d for marketed cream.
Conclusion: This study confirms that the Nanoemulsion gels provided greater permeation followed by cure rates of poorly soluble Terbinafine HCl in animal model and hence these systems could be the preferred drug carriers for drugs intended for topical use to overcome the permeability and efficacy problems.

Keywords: Terbinafine HCl, Nanoemulsion gel, permeability, poorly soluble drug, Topical antifungal, Trichophyton mentagrophytes.

INTRODUCTION
The development of dosage forms for topical drug delivery is one among the many challenging areas to the formulation scientist. Among the various layers of skin (i.e. epidermis, dermis and hypodermis), the stratum corneum of epidermis is the effective rate limiting barrier to percutaneous drug transport, as this layer is made up of dead cells of corneocytes which lack nuclei and organelles [1]. Due to its unusual composition (40% proteins, 40% lipids and 20% water) and tight intercellular junctions (corneodesmosomes), the stratum corneum is the most formidable barrier when compared to the other epithelial barriers of gastrointestinal, rectal, buccal, nasal and vaginal routes[2]. Majority of new chemical entities (approx. 40% of the drugs) currently being synthesized in R&D are lipophilic in nature [3].They show wetting difficulties and poor dissolution, eventually leading to poor penetration [4,5]. These properties present a rate-limiting step in their topical permeation and in turn cause a subsequent reduction in their efficacy. Whenever a drug is applied to the skin, whether poorly or highly soluble, only a small fraction of applied drug is able to penetrate from...

Find Another Essay On A Study on Topical Nanoemulsion Based Gel of Terbinafine HCl

What do you know? A question and overview of Philosophy. Based on the study of 'Sophie's World'by J Gaarder

2053 words - 8 pages of his son's innocence. His belief via the method of the courtroom satisfies the four conditions of knowledge, but his faith-based belief does not. If his son were guilty, he would still believe him innocent, on the basis of faith in his son .'So, after taking in a little of all of these different theories we can come to some sort of conclusion about knowledge. For something to be deemed an item of knowledge it needs justification, truth and

Effect of different concentrations of HCl reacting with CaCO3 on rate of reaction - BTEC - Plan

1009 words - 5 pages 4 Plan for Investigation Date of Practical: 9/10/1711:15am – I will have finished the practical and the conclusion by this time. 10:45am – I will finally analyse my data and draw a conclusion and evaluation based on the conclusive results I have obtained. 10:30am – I will collect my results, work out an average and present the data on a graph. 10:00am – I will then repeat my experiment so I can rule out anomalies and get an average for my

Topical treatment for prevention or treatment of scars: A Literature Review

1504 words - 6 pages ONION EXTRACT Merz Pharmaceuticals claims the over-the-counter onion extract gel, Mederma, improves the appearance and texture of surgical scars(5). Mederma states that it works for many types of scars, including acne scars, surgery scars, and scars from burns, cuts, and other injuries. Mederma has not been FDA approved a study is referenced on the website that states Mederma is (7). Onion extract (Allium cepa) contains several

A corpus-based, comparative study of ‘wage’ and ‘salary’

2295 words - 10 pages ’ and ‘salary’. This study explored whether the two words are used differently in texts, despite having extremely similar dictionary definitions. According to ‘Cambridge Dictionaries Online’, both ‘wage’ and ‘salary’ involve a “fixed amount of money” paid to an employee for their services, and they are cited as synonyms on the website ‘Thesaurus.com’. However, the two are not completely substitutable in discourse, and my investigation will show

A text based study of gender in Hamlet - English - Essay

1509 words - 7 pages besides prayer, no person in the world to turn to for help or advice, and no sense of strength in herself. Therefore she takes the only option available to her, madness. Shakespeare contrasts Ophelia’s true madness against Hamlet’s feigned insanity as a plot device. While Showalter’s argument that Ophelia’s madness is driven by erotomania is certainly interesting, it relies too much on cultural criticism and not enough on the text to be regarded

A STUDY OF RURAL DEVELOPMENT POLICY 2007-2013, BASED ON THE STRENGTHENING OF FAMILY FARMING AND THE IMPROVEMENT OF THE NEXT CAP

3104 words - 13 pages development policy, which was based on the integrated and participatory approach at local level. Implementation began in 1991 to give an opportunity for local communities to plan and to choose the way and the "path" development. The encouraging results of the first experimental application and held that the initiative has, in inverse proportion to its budget, the activation of the local population, led to a more systematic and integrated planning of

A controlled randomized study examining the effects of incentive – based exercise on quality of life before and one-year after allogeneic hematopo

1801 words - 8 pages performance status and QOL in patients before and one-year post HSCT. This study seeks to expand the existing body of research on incentive-based exercise programs on post HSCT patients and identify how a unique inpatient and outpatient incentive-based program in physical activity affects QOL. In 2013, the Cancer Transplant Institute at Virginia G Piper Cancer Center (CTI) – Scottsdale Healthcare – Shea performed 119 HSCT. CTI employs 3

This is sample treatment plan and assessment based on a fictional case study

1031 words - 4 pages support systems.Risk level: Due to lack of a supportive social network, some criminal activity, and lack of counseling services risk level is 2.CONCLUSION:Client recognizes his chemical usage as a problem and is motivated to change. Client is open to therapy, and willing to work on past and present issues. Client is aware of triggers. Based on client's age, work history, and level of motivation, it is highly probable that client will be

A speech based on education

1976 words - 8 pages I would have liked to have had an education but instead I have to work on the streets if I don't I wont have anything to eat and I wont have any place to sleep tonight. These words were spoken to me by a 10 year old Colombian boy. He was very thin and looked as though he were only 6 years old.Unlike this boy, I was born a citizen of the United States. My parents came here in the late 1970's from Colombia, the country of their birth. I grew up an

This is a topical business report on Sprint PCS cell phones and how expensive they are with added conclusions and recommendations

1591 words - 6 pages what cell phone plan was the most reasonable for them. Only the picture phone and the four company's service plans are considered for this study. The actual service of the phone for example, if the phone works in a wooded area or if the phone does not or does work in a different state, was not considered in this study.Sources and MethodsCurrent brochures, on-line web sites, and two interviews were used for background information to learn how other

Study Notes On Death Of A Salesman

2707 words - 11 pages men-not gods-are wholly responsible.· Willy is disturbed by the element of rapid obsolescence which is a highly oppressive aspect of life · the play in general is a study of the circumstances which affect human destiny in the moral universe DEATH · Lomanís suicide is obviously intended as a gesture of the heroís victory over circumstances · it is an act of love, intended to redeem his house · The

Similar Essays

A Study On Effects Of Different Levels Of Aloe Vera Gel As An Alternative To Antibiotics On Performance And Ileum Morphology In Broilers

1008 words - 4 pages suggest that this antibiotic can increase broilers’ body weight gain compared to control group (Bafundo et al., 2003; Miles et al., 2006) which is in line with the findings of the present study. In the present study, on feeding broilers with Aloe vera gel added to diet, we observed that although Aloe vera groups showed improved body weight gain compared to the control group, however, no significant difference was observed in feed conversion ratio

A Study Of Lexical Changes Of Modern English Based On Barney Stinson

3233 words - 13 pages A Study of Lexical Changes of Modern English Based on Barney Stinson's The Bro Code崔佳灿(河北师范大学外国语学院 石家庄 050024)[Abstract] Lexical change is an inseparable part of language study. With the development of science and technology, many words are created or shifted from its original meaning. By selecting the

A Comparative Study Of Breast Cancer Detection Based On Svm And Mlp Bpn Classifier

1177 words - 5 pages exploitation and understanding of such tools are the core application areas of data mining. These tools are based on ideas from computer science, machine learning, mathematics and statistics. Discovering meaningful information and helpful knowledge from several vast datasets has thus developed a significant research domain [1, 2]. Data mining has attracted many researchers and analysts in the information industry and in modern society as a

Determination Of Molecular Weight Of A Protein By Gel Filtration

3339 words - 13 pages chromatography separates molecules based on their electrical charges while affinity chromatography isolates a protein from a mixture. Materials and Methods The procedure our group used for the experiment of Determination of Molecular Weight of a Protein by Gel Exclusion Chromatography was taken from the University of Texas at San Antonio Lab Manual by Dr. Kumar (pages 7-8, experiment 6: Determination of Molecular Weight of a Protein by Gel Exclusion