Biomarker Discovery For Prostate Cancer Essay

728 words - 3 pages

Prostate cancer is the second most common cause of world-wide cancer-related death in men after lung cancer (WCRF International), and in Australia, it accounts for 30% of all new cancers in men and 13.4% of all cancer deaths in men (Cancer Australia). Currently, Prostate Specific Antigen (PSA) is the most commonly used serum biomarker for prostate cancer most routinely used by urologists. However, PSA-based screening has been shown to have high false positives and false negatives with low specificity, and it is not able to distinguish well between cancer and benign prostatic hyperplasia or between indolent and aggressive cancers, thus leading to overtreatment, especially unnecessary biopsies ...view middle of the document...

). In the last 10 years or so, MS has increasingly become the method of choice for clinical proteomics research, especially in biomarker discovery and analysis of prostate cancer (Flatley). Prostate cancer cell lines have been used widely in the search for biomarkers in order to achieve early diagnosis. Using 2-dimentional chromatography and liquid chromatography MS, human prostate cancer cell lines PC3, LNCaP and 22Rv1 have been used to identify proteins that could have biomarkers potential. Four biomarkers; follistatin, chemokine ligand 16, pentraxin and spondin-2 were validated by ELISA in the serum of patients with and without prostate cancer, and showed biomarker potential (Sardana). Later studies have validated some of the findings such as the role of spondin-2 as an independent new serum diagnostic biomarker for prostate cancer (Qian). Endosomal and lysosomal enzymes are thought to be a contributing factor in prostate cancer biology due to their involvement in energy metabolism and cell division; hence, categorizing them as a potential source of biomarkers. Lysosomal biogenesis is also suggested to be involved in the progress and onset of prostate cancer, and the isolation of exosomes, which contain proteins that are specific to the tissue from which they are derived, would enable detection of disease-specific...

Find Another Essay On Biomarker discovery for Prostate Cancer

Prostate Cancer Essay

1099 words - 4 pages spread from the prostate to tissues around it, or to other parts of the body. This is called “staging.” It is very important to know the stage if the disease to plan for the treatment. The following stages are used for prostate cancer: Stage 1: Prostate cancer at this stage cannot be felt and causes no symptoms. The cancer is only in the prostate and usually is found accidentally when surgery is done for other reasons, such as BPH. Cancer

Study of Bioinformatics, Proteomics, and Genomics

2125 words - 9 pages suitable drug therapy and dosage for the initial stage with the help of bioinformatics developed algorithms that produces less error rate sequence technologies (Abrahams E. & Silver M., 2010). Figure 1: Personalized medicine cycle and the relationship of pharmacogenomics and personal genomics with personalized medicine. Source: (Abrahams E. & Silver M., 2010) 2.1.6 Bioinformatics Application in Proteome Research on Biomarker Discovery and Drug

The Top 7 Threats to Men's Health

1452 words - 6 pages Life Tips for Men (PDF): An extensive document detailing important life tips for men looking to main a healthy lifestyle. Some tips include: eating healthy, staying smoke-free, getting routine health-screenings, managing stress, and exercising precaution while doing daily activities. Cancer (Prostate and Testicular): Oklahoma.gov: Testicular Self Exam by the National Cancer Institute (PDF): A testicular cancer information pamphlet and

Prostate Cancer

2109 words - 9 pages 1988 to 1992, chinese men in the U.S. is 15 times higher than the rate/number is in china. However by an amount of increasing detection, that is another reason for these high rates. Suggestions is that Prostate cancer could be under reported, yet some incidence in China and Japan is similar to those in Western areas. In 2012, Europe was the 3rd largest diagnosed after breast and colorectal cases at 417,000. Primarily, Prostate Cancer develops in

Prostate Cancer and Nutrition

1724 words - 7 pages Prostate Cancer and Nutrition Clinical Radiation 04/15/14 Anand Somasundaram   Prostate cancer is the most common cancer of men and the third most common cause of death from cancer. Prostate cancer usually occurs in men above the age of 50. Many men who have prostate cancer, do not show any symptoms. Screening for this cancer is usually done by a Digital rectum exam (DRE) and/or Prostate specific antigen test (PSA).Digital rectum exam is the

Prostate Cancer

4700 words - 19 pages an analysis of investigations into possible risk factors, of which, age, family history and genetics appear to show a more causative relation in the development of PC, than the remaining factors discussed. Age adjusted rates of PC for men over the age of 75 years, shows 50% to 75% have asymptomatic prostate cancer. For men 50 years or older, up to 30% have histological evidence of PC. According to Newman, AThe age-adjusted incidence rates of

Detriment of PSA Screening

2238 words - 9 pages destruction and, therefore, should not be administered on a regular basis as a means of detecting this form of malignancy. Cancer of the prostate has retained its place as the leading source of cancer apart from the melanomas and carcinomas of the skin. In addition, this disease is the second leading killer among men in the United States that pass away due to cancer.1(p164) What then is the reason for such a polarized dialogue concerning a simple

Molecular Regulation of Bone Marrow Metastasis in Prostate and Breast Cancer

2762 words - 12 pages in patients with bone metastatic PCa, and is related to bone metastatic lesion. A correlation has been reported between increased serum levels of miR-141 and the level of ALP but not that of PSA (71). As a result, the serum miRNA level can function as a new biomarker for diagnosis and assessment of metastasis. Expression of miRNAs -508-5p, -145, -143, 33a and -100 in bone metastasis is severely decreased compared with primary tumors of prostate

Thyroid cancer in Australia

1367 words - 5 pages diagnosis and timely treatment are critical for improving long term survival of papillary thyroid cancer. Therefore, in the last 5 years the discovery and identification of potential biomarkers of papillary thyroid cancer through surfaced enhanced laser desorption/ionization time of flight mass spectroscopy (SELDI-TOF-MS) has helped identify a set of biomarkers that could discriminate papillary thyroid cancer from noncancerous controls. These medical

Evaluating the Mechanism of Chemotherapy

896 words - 4 pages Powerful genotoxic reagents such as Mitoxantrone, Docetaxel, Hydrogen Peroxide, Bleomycin and radiation have been recently investigated in PSC27(Normal Human Prostate Stromal Cell Lines) cell lines and prostate cancer cell lines such as PC-3, LNCaP, DU145, BPH1 and M12 cells. These chemotherapy reagents are ultimately DNA-damaging mechanisms that break hydrogen bonds and DNA strands in DNA. There are great implications associated with the

Types of Cancer and the Impact Upon the Patient and Family Members

3628 words - 15 pages chemotherapy is the options you will get. But with these options they may extend survival and/or relieve symptoms, but won’t produce a cure usually. (Dores, 2000) Prostate, An estimated 192,280 new cases of prostate cancer will occur in the US in 2010. Prostate cancer is the most frequently diagnosed cancer in men. For reasons that remain a not clear, incident rates are significantly higher in African Americans than in whites. Incident rates

Similar Essays

Treatment For Prostate Cancer Essay

2369 words - 10 pages Introduction Studies have shown that that 25% of men that are diagnosed with cancer are usually diagnosed with prostate cancer. It has progressed so much that it is the 3rd common cause of death in men in the USA. Drugs for prostate cancer have made progressed so much in just the last 10 years. Chances of survival and control in pain have improved so much with the evolution of chemotherapy drugs. Chemotherapy is a treatment that using the

My Father And Prostate Cancer Essay

2563 words - 10 pages I reminisce with all members of my family the day we received the news from our doctor that my father had prostate cancer. We got that news like thunder in our ears, because just one year before we had lost our sister to breast cancer, and we still remember how much pain and suffering the cancer had caused. As a result nobody in our family believed that we were going to lose our father either. My father suffered prostate cancer for nearly two

Idkid, Essay

4932 words - 20 pages found on multiparametric 1H staging examination. Lac 5 lactate; Pyr 5 pyruvate; LDH 5 lactate dehydrogenase; NAD 5 nicotinamide adenine dinucleotide; NADH 5 reduced nicotinamide adenine dinucleotide. HYPERPOLARIZED 13C MRS IN PROSTATE CANCER • Wilson and Kurhanewicz 1571 by on October 9, 2014. For personal use only. jnm.snmjournals.org Downloaded from platform for biomarker identification and validation. We anticipate that miniaturization

Prostate Cancer Essay

360 words - 2 pages stage. Since the use of early detection tests for prostate cancer became relatively common, the death rate has dropped. However, it has not been proven that this is a direct result of screening. Studies are underway to try to prove that early detection tests for prostate cancer will lower the death rate. Until that information is available, whether or not you have the test is something for you to decide. Things to consider are your age and