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Coexistence Of Autoimmune Disease With Type I Diabetes Mellitus In Libyan Patients

2251 words - 10 pages

MATERIAL AND METHODS

The prospective clinical study was undertaken on 849 patients admitted in endocrine department of Tripoli Medical Center from December 2007 to July 2008. From the patients files, the concomitant disease presence or absence was also recorded; especially with reference thyroid function. The important investigations as prescribed by the physician were also recorded. patient’s serum level of T4, T3, FT4, FT3 and TSH were measured for 748 patients. The venous blood samples were taken from all the subjects in the morning after fasting overnight while TPOAb and TGAb level were measured abroad. 101 of patients with type1 diabetes mellitus were included in this study were ...view middle of the document...

05) increased in type I diabetes mellitus subjects studied compared with normal population. In table 1 and figure 1 demonstrate the prevalence of autoimmune thyroid diseases in 748 patients with diabetes mellitus. In this study we found a total of 215 patients (28.74%) have thyroid dysfunction. In which 159 patients (21.26%) diagnosed as hypothyroidism and 56 patients (7.49%) have hyperthyroidism.
Examination of figure 2 demonstrates that the number of patients with type I diabetes mellitus have hypothyroidism are 159 patients (21.26%), 105 females and 45 males, This results show that about 66% of the hypothyroidism patients belonged to female sex whereas only 34% of these cases were belong to male sex. This female predominance in the present study is also documented in different reports.

Examination of figure 3 demonstrates that the number of patients with type I diabetes mellitus have hyperthyroidism are 56 patients (7.49%), 42 females (75%) and 14 males (25%). Also the hyperthyroidism show female predominance.

There were 101 patients with type I diabetes mellitus (67 females and 34 males) examined for celiac disease and Addison's disease.
In table 2 and figure 4 reveal that patients with diabetes had a significantly higher incidence of Celiac disease. 4.95% of patients with type I diabetes mellitus studied were confirmed with the TTG as having celiac disease, and we did not come cross any case of Addison disease.
Examination of figure 5 demonstrates that the number of patients with type I diabetes mellitus have celiac disease are 5 patients (4.95%), 4 females (80%) and 1 male (20%).also the celiac disease show female predominance.
The present study shows that the age range is 1-25 years with the highest prevalence was between 10-15 years.

DISCUSSION

The aim of this study was to determine the prevalence of autoimmune diseases among Libyan patients with type I diabetes mellitus. The prevalence of these autoimmune diseases among patients with type I diabetes mellitus is conflicting at present. Very few studies have dealt with the relationship of autoimmune diseases and type I diabetes mellitus and there is only one study is available from Libya as far as we know. Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body attacks its own cells. Autoimmune diseases are a major cause of immune-mediated diseases.

The causes of autoimmune diseases are still obscure, most autoimmune diseases are probably the result of multiple circumstances, for example, a genetic predisposition triggered by an infection.

Sex seems to have a major role in the development of autoimmunity; most of the known autoimmune diseases tend to show a female preponderance, the reasons for this are unclear. Apart from inherent genetic susceptibility, several animal models suggest a role for sex steroids. Another theory suggests that the female have higher tendency to...

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