Background: Determining the rate of HIV/HCV/HBV coinfections would help us for better understanding of their epidemiological specifications specially in high risk populations such as Injection drug users(IDUs). Considering that IDUs referred to harm reduction centers and Drop in centers (DICs) are the most available and appropriate population in this field, in current study we investigated the rate of HIV/HBV/HCV coinfection among this subgroup of IDUs ,10 years after initiation of harm reduction program in Iran.
Methods: In this cross-sectional study IDUs attended to DICs in Isfahan province were enrolled. Venous blood samples obtained and HBsAg, HBcAb,HCVAb and HIVAb measured using enzyme linked Immunosorbant (ELISA) method. Demographic data and risk factors in patients with HBV/HCV, HIV/HCV and HIV/HBV coinfections were obtained by a trained social worker using a structured checklist questionnaire. Data analyzed using Chi-square test ,t-test and multiple logistic regressions.
Results: 539 IDUs with mean age of 35.3 +/-7.9 were studied. HIV, HCV and HBV infections was positive in 88(16.3%),250(46.4%) and 6(1.1%) IDUs, respectively, respectively. HBV/HCV ,HCV/HIV and HBV/HIV coinfections was presented in 65 (12.1%),6(1.1%)and 0(0%) IDUs, respectively. There was significant association between HBV/HCV coinfection and behaviours related to unsafe drug use and imprisonment. There was significant association between HCV/HIV coinfection and history of traveling, tattooing and duration of being IDU.
Conclusion: The findings of current study indicated that the rate of HIV/HCV/HBV coinfections among IDUs attending to DICs in Isfahan province was lower than that reported among IDUs .The results could be explained by effectivenessby effectiveness of harm reduction programsreduction programs in mentioned centers but for achieving more favourable results harm reduction programmsprograms should be still expanded.
Key words: HIV, hepatitis C virus, hepatitis B virus, coinfection, Drop in Center
Hepatitis B virus, hepatitis C virus (HCV) and Human immunodeficiency virus (HIV) are the three prevalent viral and blood bore infections worldwide (1).They considered as an important public health concerns due to their related health, social and economic onsequencesconsequences (2).Moreover considering the similar route of transmission in these infections ,their coinfections would be more...