This website uses cookies to ensure you have the best experience. Learn more

Current Treatment Options For Adults With Glioblastoma

2119 words - 9 pages

Inro/General Info
C3: median survival of 14.6 months from dx with standard tx of surgery, RT and TMZ. TMZ current first-line chemo agent.
E5: Gliomas are the most common form of primary brain tumors. Grade IV GBM has an overall survival of 12-15 months. Most tumors are past the point of resection when they are discovered. Therefore, healthcare providers must use “salvage therapy” which typically leads to only a 15-16% 6 month PFS.
J10: From the time of recurrence, median survival is 6-8 months.

Current Standard of Treatment
C3: MGMT expression is correlated with resistance to TMZ, but TMZ will eventually overcome this. When comparing standard adjuvant TMZ vs. a dose-dense schedule, there is no difference in overall survival or progression-free survival. However, there is an increased toxicity with dose-dense, with the most commonly experienced toxic side effects including lymphoma and fatigue. Currently no good data, but suggests that patients who progress early may respond differently to continuous dose-dense TMZ.
E5: Current standard therapy is resection of the tumor plus radiotherapy and TMZ.
G7: TMZ dose of 75 mg per square meter of body surface area daily during standard fractionation therapy at 60 Gy for 6-7 weeks and then a dose of 150-200 mg per square meter per day for 5 days each 28 day cycle after radiotherapy.

Bevacizumab
C3: BRAIN study showed that BEV + standard RT and TMZ vs. RT and TMZ alone increased PFS (87% to 52%, P=0.0001). Some evidence (don’t know where from) that anti-VEGF therapy increases tumor invasion.
E5: Bevacizumab (BEV) is a monoclonal antibody that inhibits VEGF. It had previously been approved for treatment of metastatic colorectal cancer, non-small cell lung cancer, breast, ovarian , and renal cancer. The E5 retrospective study evaluated the success of treatment with MRIs and neurological function with the Response Assessment in Neuro-Oncology. When comparing patients with grade IV GBM treated with the standard radiotherapy and concomitant chemotherapy with TMZ either with or without salvage BEV, the median survival was 8.9 months for those treated with BEV and 5.6 months for patients who did not receive BEV. BEV was first used to treat recurrent malignant glioma in 2005. BEV has a significant survival benefit for patients with grade IV glioma. It may also lead to a decreased required dose of corticosteroids. Side effects of BEV include hypertension and proteinuria.

Breaking the Blood-Brain Barrier (Convection Enhanced Delivery and Gliadel Wafers)
C3: The blood-brain barrier blocks most molecules that are larger than 500 Daltons. BCNU wafers increase mean survival to 13.1 months compared to 10.9 months placebo. FDA approved Gliadel for treatment of newly diagnosed GBM in 2003. Combo of wafers and concomitant radiochemotherapy with TMZ may reduce systemic toxicity because it takes advantage of the sensitizing effects of TMZ and BCNU. Complications of implantation include cerebral edema,...

Find Another Essay On Current Treatment Options for Adults with Glioblastoma

Ayurvedic Treatment Options for Cervical Cancer

764 words - 4 pages The traditional Indian medicine known as Ayurvedic Medicine, originated over 5,000 years ago. It emphasizes on re-establishing the balance within the body through diet, lifestyle, exercise, and body cleansing, and on the health of the mind, body, and spirit. Today it is used as it has been for many years to help treat certain types of cancer - with cervical cancer being one of them. Over the last ten years, Ayurvedic medicine has been growing

Overview and Evaluation of Available Treatment Options for Bipolar Disorder

1443 words - 6 pages Overview and Evaluation of Available Treatment Options for Bipolar Disorder Bipolar Disorder is a mood disorder previously known by the name manic-depression. In modern times it has been renamed Bipolar disorder (BPD) to emphasize the dual mood character of the illness that is quintessential in its most common clinical presentation (Columbia Electronic Encyclopedia, 2008). Those afflicted with Bipolar Disorder typically experience alternating

Caring for Adults With Chronic Kidney Disease

1531 words - 6 pages ). Treatment options. Retrieved from http://www.kidney.ca/page.aspx?pid=336 The Kidney Foundation of Canada (n.d.c) What is kidney disease?. Retrieved from http://www.kidney.ca/page.aspx?pid=320 Koufaki, P. & Kouidi, E. (2010). Current best evidence recommendations on measurement and interpretation of physical function in patients with chronic kidney disease. Sports Med, 40 (12), 105S-1074. National Kidney Disease Foundation. (2012a). Chronic

In adults with anorexia nervosa, is participating in olanzapine (low dose) or olanzapine plus Cognitive-Behavioural Treatment for Eating disorder (CBT

1738 words - 7 pages are approved by Food and Drugs Administration (FDA) for the treatment of anorexia nervosa2. However, during the last few years, even though the dearth of studies demonstrating efficacy, like “atypical neuroleptics medications,” olanzapine and risperidone were well tolerated by patients and improved symptoms, increased rate of weight gain and reduced in obsession scores. And also, the studies found that effective with cognitive behavioural therapy

Comparing Various Treatment Options for Sexual Offenders and Their Efficacy Rates

2063 words - 8 pages Treatment for Sexual OffendersComparing Various Treatment Options for Sexual Offenders and Their Efficacy RatesDenay TaylorAmerican Public University SystemCMRJ205 Rape and Sexual AssaultDr. Cassandra EmeryJune 22, 2014AbstractThe assessment and treatment of sexual offending has varied greatly within the last 40 years. The establishment of sexual offender treatment began in the 1970's where medical officials focused on reducing criminal

The Importance of Exercise as Preventative Medicine & Treatment for Depression Among Older Adults

2998 words - 12 pages gone unnoticed among older adults. This makes it a concern to society because of the aging population in Canada, with about 14% of the population being over 65 years of age. The influx of older adults with in the population is starting to put a huge strain on the Canadian healthcare system. As they get older, people tend to develop health problems, increasing their use of health services. By using exercise as a preventative treatment for

Current Treatment Strategies for Parkinson's Disease; Are the costs to the community of developing new treatment strategies justified?

1293 words - 5 pages Discuss current treatment strategies for Parkinson's disease. How can the patient's quality of life be preserved? Are costs to the community of developing these new treatment strategies justified? Justify your answer.Parkinson's is a neurodegenerative disease, which is caused by a loss of dopamine producing cells in the brain . The disease is progressive and debilitating and is outwardly manifested in tremors, stiffness and rigidity

Medical Treatment for Children With Autism Spectrum Disorder

1226 words - 5 pages wondered such as what are the current treatment options for those with autism. I was also interested in learning if this could be a curable disorder. It is not, however research is heading into the right direction to correct the main symptoms associated with autism. Information about the biology of autism was easy to find. Many credible websites with valuable material was easy to find. Finding information about the future of autism treatment was more

Assisted Outpatient Treatment For Criminals with Mental Disorders

941 words - 4 pages asserts that AOT “allows the courts to order outpatient treatment for people with severe mental illnesses who are least able to help themselves or most likely to present a risk to others, giving family members and the mental health community a tool to help very sick people who cannot make their own medical decisions” and that almost half of the millions of diagnosed cases of schizophrenia or manic depression, which are considered to be the two

The Most Effective Form of Treatment For People With OCD

1218 words - 5 pages successful 80 percent of the time in considerably decreasing obsessions and compulsion, making it the most effective researched treatment for obsessive-compulsive disorder. In ERP or exposure and response prevention, patients work with their therapists creating a list of all of their fears ranking them from most to least anxiety inducing. After completing this list, they work with their therapist engaging in activities that allow them to confront their

Assessments and Developmental Treatment Plan for a Child With Autism

1683 words - 7 pages Services with Vimmi from Adventure Place. Vimmi has observed Daniel in school and noted him to be engaging in reciprocal and sustained play with other children in his class. He did seem more reserved around adults, but is reportedly fitting in with the classroom routine. Adventure Place has continued to work with his family on community resources and behavioral strategies for the home environment. ADOS-2: For today’s assessment we have administered

Similar Essays

Treatment Options Used For Children With Autism Spectrum Disorder

2005 words - 9 pages literature review will conclude with a concise discussion. In addition, it is important to compare the treatments used to control ASD. Treatment options used for children with autism by parental, caregivers and clinical Autism Spectrum Disorder is not curable but it can be controlled using a certain type of treatments. There are various types of treatments used by parental, caregiver and clinical. The treatments can be separated into behavior and

Applying Autophagy And Apoptosis For Strategies To Improve Treatment Of Glioblastoma

707 words - 3 pages The pathways controlling autophagy and apoptosis should be targeted as the strategies to improve treatment of glioblastoma. The proteins to be targeted are Beclin, p62 and EGFR. Survival related or anti-apoptotic protein such as Bcl2 were found to be upregulated in glioblastomas whereas autophagy proteins like Beclin were found to be downregulated. The autohagy (Atg) proteins function at several discrete but continuous steps in autophagy which

Treatment Options For An Incurable Disorder

2123 words - 8 pages Center are two of the most respectable sources for families who have children with autism to search for possible treatment options suitable for their children. Both these organizations list applied behavioral analysis one of the most successful treatment options. Shock therapy (a therapy not included in either Autism Speaks Incorporated or the National Autism Center) is a highly debated treatment due to ethical reasons. Autism affects more people every year. For now, there is no cure for autism but if families choose the correct treatment method for their children, the symptoms can be greatly reduced.

Treatment Options For Childhood Onset Schizophrenia

712 words - 3 pages Child Onset Schizophrenia Treatment Options The present clinical treatment strategies (pharmacological, psychosocial, family intervention) for child onset schizophrenia (COS) are varied and abundant but very costly because of its rarity and the number of sites required to research the disease (Asarnow, Thompson & McGrath, 2004). Let it be noted that remission of COS is rare but it is the goal of research to accomplish. The American Academy of