This website uses cookies to ensure you have the best experience. Learn more

Cystic Fibrosis And Gene Therapy. Essay

1337 words - 5 pages

Contents1 Summary2 Cystic Fibrosis3 Gene Therapy4 Gene Therapy and Cystic Fibrosis5 Problems With Gene Therapy6 Recent Developments in Gene Therapy7 Ethical Issues Related to Gene therapy8 ConclusionSummaryGenes, which are carried on chromosomes, are the basic physical and functional units of heredity. The amount of information geneticists have discovered about genes in the last 20 years is staggering. It was only in 1973 that the first recombinant DNA methods were successfully used. Since then development of techniques that allow geneticists to locate the position of genes has led to a greater understanding of the causes of genetic disorders. Now scientists are able to consider treating people with genetic disorders by introducing normal genes into body cells. Gene therapy has been successfully used in a few cases and many more genetic disorders are currently being investigated. The future looks promising.The aim of this report is to examine Cystic Fibrosis as a genetic disorder, how it affects the lives of those born with it and to investigate gene therapies associated with it. This report also investigates the ethical issues and recent developments in gene therapy as well as the factors that have kept it from becoming an effective treatment for genetic disorders.All of the information presented in this report has been obtained from internet websites and various school textbooks.Cystic FibrosisCystic Fibrosis is an incurable hereditary disorder that causes the body to produce an abnormally thick, sticky mucus that clogs the pancreas and the lungs, leading to problems with breathing and digestion, infection, and ultimately, death. The disease is characterised by a defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This results in irregular chloride and sodium ion conductance in epithelial cells of a number of different organ systems. (Oxford University of Gene Medicine, 2000, uk/~genemed/) This means that it prevents salts from moving through body tissues properly, disrupting digestion and more importantly leading to chronic lung infection.Cystic fibrosis is a recessive genetic disorder and is the most common life-threatening genetic illness in the majority of Caucasian countries. If both parents are carriers of the defective cystic fibrosis gene, their child has a 25 percent chance of inheriting both those genes and developing the disease (see appendix fig 1). If only one abnormal gene is inherited (that is, from only one parent), the child will not have symptoms of the disease but will be capable of passing on the defective gene to the next generation. One in 40 Caucasian people are healthy carriers of the cystic fibrosis gene. Three decades ago most babies born with cystic fibrosis died in early childhood, but advances in diagnosing and treating the disease have significantly improved the chances of survival.Gene TherapyGene therapy is essentially the removing and replacing of a particular gene...

Find Another Essay On Cystic Fibrosis And Gene Therapy.

Gene Therapy and Genetic Disorders Essay

1397 words - 6 pages wasn't working as it is supposed to be, or changing genes that are not working properly. Cystic fibrosis, hemophilia and sickle cell anemia are among the diseases where gene therapy has been considered. Diseases that are incurable in which gene therapy has also been considered include Parkinson’s, HIV/AIDS, Alzheimer’s, diabetes, cancer, and heart disease

Advantages and Disadvantages of Gene Therapy

1623 words - 6 pages cystic fibrosis. Those infected suffer from an inability to regulate the transfer of chloride ions in and out of the cells in the colon, pancreas, and the lungs due to a defective gene. The gene typically would encode a protein that performs the regulation which is the cystic fibrosis transmembrane conductor or CFTR. Since the cell isn’t able to regulate chloride ion properly, sticky mucus then forms, affecting the pancreas tubules and bronchioles

Implications of and Attitudes toward Gene Therapy

2223 words - 9 pages Viewpoints: As gene therapy is very controversial, there are contrasting perspectives on the issue. Proponents of gene therapy are attracted to the idea of providing a cure for a disease, instead of drug therapy and only easing the symptoms. Many can see the potential of gene therapy to become a huge part of medicine in the future of patient treatment. Dr Frederick Hecht says “most gene therapy for diseases such as cystic fibrosis and

The Pros and Cons of Gene Therapy

2200 words - 9 pages What is Gene Therapy and what is it used for? Gene therapy (otherwise known as somatic gene therapy or therapeutic gene therapy) is a process that is used to correct defective genes responsible for development of various diseases. ( There are two main types of gene therapy; somatic (body) cell gene therapy and germ line gene therapy. As it suggests, somatic gene therapy is correcting

Gene Therapy and Its Effect on Cancer

3602 words - 14 pages Gene Therapy and Its Effect on Cancer The era of scientific advancement in the twentieth century has encouraged several scientific fields to merge into a new, futuristic science called Biotechnology. One idea behind Biotechnical science is taking advantage of molecular biology. At the forefront of this advancement is gene therapy which " attempts to treat disease at its origin on the molecular level"(Kreeger,1996). "Essentially, this

Excellent Cystic Fibrosis Report....has causes, description, how it can be detected, and treatments!

541 words - 2 pages and the pancreas. This causes the body's mucus (the slimy secretions that moisten and protect body tissues) to become extra thick and sticky. The mucus clogs the lungs and makes it difficult to breathe, and this can lead to infections, coughing, and wheezing. Cystic fibrosis also affects the pancreas (an organ that makes lots of proteins called hormones and enzymes) by not allowing it to deliver enzymes that digest food in the intestines. This is

Living and Coping with Cystic Fibrosis in the South Asian Community

1694 words - 7 pages A widely accepted Caucasian disease has since changed; as cases of its existence are appearing in the South Asian Population (Orenstein, Rosenstein and Stern, 2000). First discovered in 1989, Cystic Fibrosis (CF) is a genetically predetermined condition, its presences is lifelong and highly complex, which is why many CF sufferers and families develop various mechanisms in order to adapt to the condition (Tippingemail, Scholes, Cox, 2010). Cystic

Gene Therapy and its Potential to Cure Deafness

1418 words - 6 pages Gene Therapy and its Potential to Cure Deafness Losing a vital sense makes living life more difficult. Gene therapy, the process of replacing faulty genes with genes genetically engineered to replace them, can potentially cure deafness. Yashimo Raphael experimented with intentionally deafened guinea pigs and the gene Atoh 1, a gene said to replace lost hair cells in the inner ear. He found that hair cells grew, but were not fully functional

Gene Therapy for Multiple Sclerosis, Cancer, and Sickle Cell Diseases

731 words - 3 pages , it is class of diseases characterized by out-of control cell growth. Currently there is around 100 different types of cancer. In current times some forms of cancer are already curable but some are only curable up to certain stages. Currently in the word there is around 13.5 million diagnosed with cancer. It will benefit the whole world if gene therapy is able to cure cancer. Many people lives will be saved and we will be done with this dreaded

Critique of 'The ethics of Human Gene Therapy' by L Walters and J Gage Palmer

947 words - 4 pages IntroductionThe article 'The Ethics of Human Gene Therapy' by L Walters and J Gage Palmer is a report of the first human gene therapy experiments, and the ethical issues surrounding it. It is an account of the lives of the people -particularly two young girls- who received the therapy and the associated outcomes and impacts it had, both on her and her family's life, and that of the general public.A major part of the article presents seven

Gene Therapy and Genetic Engineering: Should It Be Approved in the US?

3126 words - 13 pages receiving the treatment the patients' scores on movement tests improved on average by 30 percent.(Gene Therapy Special News Items, 1.)” Genetic engineering, and its form dealing with humans, gene therapy, is a process in which genes are replaced or "tweaked" to acquire a certain trait or cure an illness or disease. This can be performed in the fetal stage through adulthood. While genetic engineering and gene therapy can help prevent disease and

Similar Essays

Gene Therapy For Cystic Fibrosis Essay

1009 words - 5 pages rhesus macaque monkeys. More research in this field is necessary as it is unclear which patients need which level of gene expression to combat their disease and the ideal age for gene therapy has to be evaluated. [71] 9.2 Personalized Therapies With the discovery of the different classes of Cystic Fibrosis a more systematic approach is becoming an aim in research. Patients should not be treated equally but every class of CF should get a mutation

Cystic Fibrosis: A Case For Gene Therapy

752 words - 3 pages Fibrosis, then uses a retrovirus to ferry the complete normal gene into the cells. Once inside, the normal gene began reproducing a protein Cystic Fibrosis transmembrane regulator in the normal fashion. As a result of this, the gene opens the chloride ion channels and thus allowing chloride ions to leave the membrane of the cells through these channels.However, this technique will not always work. This method called "˜replacement gene therapy

The Cystic Fibrosis Gene Essay

1262 words - 5 pages copies of the mutated gene into the affected person's airways so it can replace the mutated nucleotides. This known as gene therapy.      A drastically different approach taken in an attempt to cure cystic fibrosis, performed as a method of preventive medicine, involves correcting the disease while the affected "person" is still an embryo. Test tube fertilization from affected parents and gene diagnosis during

The Symptoms, Causes And Remedies For Cystic Fibrosis

1287 words - 6 pages the way cars need lubricants to keep all parts moving and functioning properly. However, people whom have this mutated gene produce excessive amounts of a sticky, thick type lubricant. “The disease is caused by mutations in a single gene” (Fitzgerald). “First identified in 1989, this is a 230 kb gene on the long arm of chromosome 7 which encodes a 1480 amino acid protein called Cystic Fibrosis transmembrane regulator (CFTR). Mutations in a membrane