Choose a chronic disease Epid Subject covered in this course and write a proposal for research that you think needs to be done in this area. The sections need to fit into the space provided.
Title: Vitamin D status of children with severe early childhood caries: a case-control study
Background and significance-----
Severe Early Childhood Caries (S-ECC) affects the health and well-being of young children. Quality of life is reduced among those suffering from S-ECC. This can include pain, disturbed sleep and behavioral changes. Children with severe decay can also have altered eating habits and preferences. Therefore, rampant caries can influence nutritional health. A few reports reveal that some may be suffering from a degree of malnutrition, specifically anemia and low iron concentrations, and have altered growth patterns impacting height and body mass index. Thus, it is plausible that those with S-ECC are also deficient in important vitamins and nutrients, including vitamin D.
Specific Aims (limited to two )
1. The purpose of this study will be to determine the association between serum concentrations of 25 (OH) D and S-ECC in preschool children.
2. Secondly, it is of great importance to compare the results obtained from this study to those of a study previously conducted in Canada.
Patient Population: Inclusion and exclusion criteria
From December 2013 to October 2015, otherwise-healthy children with S-ECC will be recruited from UFHealth in Gainesville, Florida on the day of their dental surgery. Since the case definition for S-ECC is age specific, participants must be ≤ 71 months of age. Age-matched free controls will be recruited from the community by advertisement and will undergo a dental screening by a study team member. Children will be assessed using the dmft index (a cumulative score of decayed, missing, filled primary teeth). Those having a dmft score of 0 will be considered caries-free.
Database selected or source of patients:
144 preschool children with S-ECC were recruited from UFHealth in Gainesville, Florida on the day of their slated dental surgery under general anesthetic. 122 caries-free controls were recruited from the community.
Experimental Instruments or specific data to be analyzed
Children will undergo a blood draw for Vitamin D (25(OH)D), calcium, parathyroid hormone,...