Dna Sequencing Of Cancer Genes Essay

4235 words - 17 pages

DNA SEQUENCING OF CANCER GENESTABLE OF CONTENT3Abstract 3Introduction 4DNA Sequencing 51. Sanger Dideoxy Sequencing 52. Fluorescent Sequencing 63. Circle Sequencing 7Current Scenario 9Improving Efficiency of DNA Sequencing 91. Computerized Analysis 112. Parallel Algorithm 11A. Algorithm for finding strong feature gene sets 12B. Parallel Solution 12C.Molecular Genetics 13D. Molecular Epigenetics 14Quality Assurance and Standards 141. Report Writing 152. Storage and Confidentiality 173. International Co-Operation 184. Government Regulation of Genetic Testing 19Knowledge Repositories 191. National Institute of Health 202. Breast Tumor Bank 203. Cancer Tissue Bank 21Conclusion 22Reference AbstractThe DNA testing of BRCA1 and BRCA2 are considered to be one of the most important testing in healthcare as it can be used to predict the existence of cancer. In this paper, the current issues involved in such testing were discussed. Then various solutions were discussed for some of those problems. Computerized analysis, parallel algorithm and statistical methods were explained in detail. These techniques are supposed to improve the efficiency of the testing. Also the various standardization and regulation issues were discussed. The repositories for DNA testing are very inadequate in the present condition and the solutions for such repositories were also explained in detail.IntroductionThe introduction of DNA sampling has opened a new era in bio technology. Modern DNA sequencing techniques are being employed for huge number of applications. In medicine and forensic science, DNA sequencing plays a major role. It is useful in all research studies about living organisms as it can provide good heritable information. Genetic testing of BRCA1 and BRCA2 genes are very useful in predicting cancer. With the advent of such low cost testing, the medical field has been hugely benefited. However certain issues still exists in genetic testing and they have to be resolved for an efficient testing and reporting. Research is still going on to improve the testing methods and the various standardization processes involved in these tests across various nations. Also, the resources available for such testing are very scarce at the moment and work is being done to improve such resources.DNA SequencingFor a long time the DNA sequencing was done using the chain-termination method and then the rapid DNA sequencing method was developed which made the whole process a lot easier. The DNA sequencing process is performed in order to determine the sequence of bases in a DNA molecule. The DNA molecule contains information about how the proteins should be manufactured. This information is stored in the sequence of bases (nucleotides) that compose the molecule. [11] The bases normally are adenine, thymine, cytosine and guanine. They are denoted as A, T, C and G. The process of reading the sequence of letters in a piece of DNA is called DNA sequencing.Fig 1: 2-D Structure of DNA Molecule...

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