The Vesicular carrier based drug delivery systems are a recent breakthrough to achieve target specificity and minimization of adverse effects associated with drug. Inspite of such novelty associated, carrier systems suffer from drawback like non-uniformity in size. The present study is based on determination of optimum process conditions to obtain vesicles of uniform size carrying drug Aceclofenac. The results indicate a strong influence of temperature, time and rotations per minute of rotary evaporator and sonication cycles, amplitude and time on the size of Liposomes and transferosomes prepared using lipids and surfactants.
Key words- Nanocarriers, size, Process optimization
The vesicular carrier based drug delivery system incorporating nonsteroidal anti-inflammatory drugs are a need for therapy of inflammatory disorders because of their enhanced localization to the desired site of action thereby reducing the incidents of side effects. Aceclofenac is selected in the present study as the drug has many side effects when administered by conventional oral route such as gastro-intestinal disorders, in particular dyspepsia, abdominal pain, nausea and diarrhea and therefore a lesser adherence of patient to the treatment. Topical delivery of drugs has many advantages such as avoidance of hepatic first-pass metabolism., improved patient compliance and ease of access, provide a means to quickly terminate dosing sustained therapeutic drug levels, possible self – administration, non-invasive (no needles or injections needed),avoids food related Interaction, reduction of doses as compared to oral dosage forms and intravenous therapy. Topical route allows drug to diffuse out of its vehicle onto the surface tissues of skin. There is no significant obstacle to penetration, once the drug permeates through stratum corneum of epidermis of skin [1, 2, 3, 4]. Topical NSAIDs have been reported to have reduced incidences of systemic side effects like gastric bleeding and peptic ulcer. [2, 3, 4, 5]
For permeation of drug through stratum corneum layer, novel strategies can be adopted by the use of vesicular carrier based drug delivery system and novel penetration enhancers. But there are some shortcomings associated with the vesicular carrier drug delivery systems such as lack of control over drug release rate; insufficient loading of drugs and lack of means to override biological barriers.[5,6,7,8,9]
In the present study, the effect of process parameters on the design of vesicular systems loaded with Aceclofenac has been studied and loaded drug carrier such as Liposomes, was designed by optimizing the components of formulation and the process parameters in order to prepare the drug loaded carriers with uniform size, high drug entrapment efficiency and good permeation characteristics.
Materials and Methods-
For the studies, Phospholipids were obtained as gift samples from Lipoid Corporation, Germany. The drug Aceclofenac was obtained...