Effect Of Process Parametrs On Vesicular Systems

1270 words - 6 pages

The Vesicular carrier based drug delivery systems are a recent breakthrough to achieve target specificity and minimization of adverse effects associated with drug. Inspite of such novelty associated, carrier systems suffer from drawback like non-uniformity in size. The present study is based on determination of optimum process conditions to obtain vesicles of uniform size carrying drug Aceclofenac. The results indicate a strong influence of temperature, time and rotations per minute of rotary evaporator and sonication cycles, amplitude and time on the size of Liposomes and transferosomes prepared using lipids and surfactants.

Key words- Nanocarriers, size, Process optimization

The vesicular carrier based drug delivery system incorporating nonsteroidal anti-inflammatory drugs are a need for therapy of inflammatory disorders because of their enhanced localization to the desired site of action thereby reducing the incidents of side effects. Aceclofenac is selected in the present study as the drug has many side effects when administered by conventional oral route such as gastro-intestinal disorders, in particular dyspepsia, abdominal pain, nausea and diarrhea and therefore a lesser adherence of patient to the treatment. Topical delivery of drugs has many advantages such as avoidance of hepatic first-pass metabolism., improved patient compliance and ease of access, provide a means to quickly terminate dosing sustained therapeutic drug levels, possible self – administration, non-invasive (no needles or injections needed),avoids food related Interaction, reduction of doses as compared to oral dosage forms and intravenous therapy. Topical route allows drug to diffuse out of its vehicle onto the surface tissues of skin. There is no significant obstacle to penetration, once the drug permeates through stratum corneum of epidermis of skin [1, 2, 3, 4]. Topical NSAIDs have been reported to have reduced incidences of systemic side effects like gastric bleeding and peptic ulcer. [2, 3, 4, 5]
For permeation of drug through stratum corneum layer, novel strategies can be adopted by the use of vesicular carrier based drug delivery system and novel penetration enhancers. But there are some shortcomings associated with the vesicular carrier drug delivery systems such as lack of control over drug release rate; insufficient loading of drugs and lack of means to override biological barriers.[5,6,7,8,9]
In the present study, the effect of process parameters on the design of vesicular systems loaded with Aceclofenac has been studied and loaded drug carrier such as Liposomes, was designed by optimizing the components of formulation and the process parameters in order to prepare the drug loaded carriers with uniform size, high drug entrapment efficiency and good permeation characteristics.
Materials and Methods-
For the studies, Phospholipids were obtained as gift samples from Lipoid Corporation, Germany. The drug Aceclofenac was obtained...

Find Another Essay On Effect of Process Parametrs on Vesicular Systems

Measuring the Effect of Regional and Preferential Trade Agreements on Multilateral Trading Systems

3758 words - 15 pages , especially of WTO. A number of studies have been carried out in this direction as well in order to find out the extent to which these agreements have positive or negative effect on the economic activities in the countries where these agreements have been preferred over multilateral trading system (Lloyd, 2002). The evolutions of these agreements have accelerated in the recent past and an average WTO member has agreement with more than 15

Effect of Heart Rate, Blood Pressure and Breath Rate on Cardiovascular and Respiratory Systems

2122 words - 8 pages This study is relevant because it gives more insight on the body’s ability to adapt to stress/ exercise or how the cardiovascular and respiratory systems respond to increase in metabolic activity. When stimulus such as an exercise is activated, almost all the organs and systems in the body are affected. The body is designed to be able to handle such requirements. The cardiovascular system is one of the systems involved in the body’s

Causation: Understanding the Process of Cause and Effect

1415 words - 6 pages effecting or apparent to the observer (D. Shanks 1985). A simple example of causation is the process of turning a light switch on or off. In doing this one can see the instant impact of either the light turning on or off. Although there are a number of factors that must be considered such as the effect of human nature. Even though an action of turning the light switch to the on position provides direct intention, which created a cause and

Effect of Imperialism on Algeria

1679 words - 7 pages Algeria started as independent groups of natives under Ottoman control located in North Africa, East of Morocco. The people lived for years operating well under their own rules, culture, and pirating ways. The French were attracted by the Algerians' control of the Mediterranean Sea and the trading opportunities it had. Expanding on their empire, the French wanted to gain this influential power and ease of trading in the Mediterranean. After

Effect of Bullying on Society

932 words - 4 pages model. That sounds rough and cruel, but that was only pre-school. In junior high and high school, the real bullies prevail by adding on to the foundation that was setup at an early age. From fourth to eighth grade, ninety percent of students report themselves as being victims of bullying. (Dosomething.org) Most teachers do not even notice or care about bullying. They see it as a part of school and the process of growing up. Growing up does have

Effect of Concentration on Osmosis

2617 words - 10 pages Effect of Concentration on Osmosis Aim To find out how the concentration of sucrose solution affects the mass of the potato chip left in the solution for one day. Prediction I predict that when the sucrose concentration is low the potato chip will gain mass. This is because there will be a higher sucrose concentration in the potato chip so water will go into the potato from the solution. I predict that when there is a high

Audens Poems on The Process of Mourning

791 words - 4 pages The process of mourning will be different for ever individual, the emotions that are felt during this time can range from hate to love. W.H. Auden’s “Funeral Blues” describes the day of someone who is mourning a loved one and experiences feelings such as denial and depression. Emily Dickinson’s “Because I could Not Stop for Death” on the other hand describes the events someone feels as they being to accept death. There are many similarities

Effect of List Position on Free Recall

763 words - 3 pages In our daily lives, we constantly try to store and retrieve information from our memory. Sometimes the retrieval process is quite simple, while other times it seems to be almost impossible. An experiment was done to investigate the effect of list position on free recall. The serial position effect refers to the U-shaped pattern presentation on a free recall task. The accuracy of item recall depends on the order that the stimulus is presented

The Effect of Cell Phones on Health

1573 words - 6 pages our lives. Mostly, the effect has been positive in many ways. But, as it is with anything, overuse and abuse has brought out its dark side and the effect of unintended consequences. One of the unintended consequences of the cell phone is its effect on the health of its users and even the health of those around them. What is the effect of the cell phone on our health? Researchers are examining the health risks associated with cell phone use

Effect of Stress on Decision Making

3176 words - 13 pages Effect of Stress on Decision Making Stress must be present to ensure our very being. One may wonder about the validity of this statement, but it is quite true. Stress plays a vital role in the way we make decisions (Massa et al, 2002, pg 1). “Problem solving and decision making in demanding real-world situations can be susceptible to acute stress effects which manifest in a variety of ways depending on the type of decision. The negative

The Effect of Day Care on Children

1470 words - 6 pages The Effect of Day Care on Children Because many stay at home mothers are entering the work force, there is a higher demand for day care centers for the mothers’ children. The topic of day care centers and whether they are beneficial to young children is becoming discussed more frequently. An increasing number of parents are becoming more cautious about the type of childcare they choose for their children. Some parents are adhering to the

Similar Essays

The United States Contract Bidding Process And Its Effect On The Readiness And Reliability Of Our Nation’s Military Communications Systems

917 words - 4 pages Title of my paper: The United States Contract Bidding Process and Its Effect on the Readiness and Reliability of our Nation’s Military Communications Systems Introduction The United States Government has fostered a lowest bidder mentality among corporations and firms vying to provide government services. The resulting outcome of this system has allowed firms to sacrifice the quality in the materials, manpower and resources to construct and

The Effect Of Shading On Various Photo Voltaic Systems

1638 words - 7 pages 1. Introduction The shading is the most important causes of vulnerability for the power output of PV module. 5% (for example) of shading on the PV module leads to a decrease in the ability of the module may reach more than 60 or 70% of the module power. This is due to, the connected cells in a string, where the cell with the lowest illumination is the main reason for the reduction of the current series in full. On the other hand, it is

The Effect Of High Frequency Trading Systems On Financial Markets

1394 words - 6 pages because price movements have become so large and volatile. Thus, this offers substantiation of what is the perceived effect of HFT on market participants. Additionally, this may also be why the SEC is scrutinising HFT amid concerns it is placing other investors at a distinct disadvantage (Mackenzie, 2009). Works Cited Brogaard, J. (2011). HIGH FREQUENCY TRADING AND ITS IMPACT ON MARKET QUALITY. Available: http://www.nber.org/public_html

Television's Effect On The Political Process

574 words - 2 pages The introduction of television and its components into the political process has greatly influenced politics. Television has given politicians a whole new way to communicate and express their beliefs to voters. There are a few significant effects that this form of media has had on the political process.Firstly, television tends to make political life more fluid and volatile. Outcomes are much harder to predict with campaigns now because a single