Effects Of Ethanolic Extract Of Aconitum Heterophyllum Root

886 words - 4 pages

The present study was to designed to carriedout the in vitro antioxidant and in vivo nephroprotective activities of ethanolic extract of Aconitum heterophyllum root (EEAHR) in glycerol induced acute renal failure in Wistar albino rats. The antioxidant activity of EEAHR was evaluated by 2, 2-diphenyl-picrylhydrazyl (DPPH assay), nitric oxide radical scavenging (NO assay), hydrogen peroxide (H2O2 assay) and ferric reducing antioxidant power (FRAP) scavenging activity assays. Twenty four Wistar albino rats were used and divided into four groups of six each for assessing the nephroprotective activity. The group 1 received normal saline, group-2 received hypertonic glycerol (8 ml/kg) alone and group 3 & 4 received glycerol + 250 mg/kg of EEAHR and glycerol + 500 mg/kg of EEAHR respectively. The EEAHR was given orally 60 minutes prior to glycerol injection. The renal injury was measured by serum creatinine, blood urea nitrogen, total proteins, albumin, urine output and histopathological changes. Results showed the in vitro antioxidant activity was found to be equal to Vitamin C and in an in vivo study, EEAHR treated animals showed significant attenuation of biochemical parameters and histopathological changes of the kidney compared to glycerol treated group.. And it was found to be more siginificant with EEAHR500 mg/kg than 250mg/kg. To conclude the ethanolic extract of Aconitum heterophyllum root has shown significant in vitro antioxidant activity and nephroprotective activity in glycerol induced acute renal failure in Wistar albino rats and it is likely to be mediated through phytochemical constituents and its antioxidant activity.

Key words: Nephroprotective, Aconitum heterophyllum root, Antioxidant activity, Glycerol, acute renal failure,

Acute kidney injury is associated with increased mortality and morbidity in undeveloped and developing countries. Acute kidney injury previously termed as acute renal failure (ARF) is reversible condition where there is an abrupt decline in renal function, manifested by acute elevation in plasma blood urea nitrogen (BUN) and serum creatinine, occurring in hours to days to weeks [1]. The aetiology of ARF is divided into prenatal, renal and post renal. Prerenal failure is the most common form of ARF, is mainly due to decrease in renal blood flow. Before kidney damage occurs, if the cause of the decreased renal blood flow is identified and corrected, the damage is reversible & it accounts for 40-70% of cases [2]. Intrinsic acute renal failure involves damage to parenchymal and it can effect the blood vessels, glomeruli, tubules and/or the interstitium [3]. The most frequent cause is acute tubular necrosis, a disorder caused by ischemic or nephrotoxic injury to the kidney[4]. Other intrinsic renal causes are interstitial nephritis, atheroembolic disease [5] and glomerulonephritis and rhabdomyolysi [6]. Intrinsic renal causes accounts 10-50% of cases [7]. Rhabdomyolysis, also common cause of ARF, is a...

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