Effectively Treating Fungal Problems With Terbinafine Hydrochloride

1341 words - 5 pages

Terbinafine Hydrochloride: Effectively Treating Fungal Problems

Abstract

Lamisil, which is chemically terbinafine hydrochloride, is the premier antifungal drug on the market. It effectively destroys fungal problems ranging from athlete’s foot to onychomycosis. However, Lamisil has a number of problems associated with it, including cost, side effects, and even effectiveness. Therefore, I created two analogs in an attempt to improve Lamisil, which I will discuss in my paper.

Plenty of fungal problems exist, including athlete’s foot, jock itch, ringworm, and onychomycosis (fungal infection beneath nails). However, many antifungal drugs exist as well, such as Lamisil, which is the most effective. Using the molecule terbinafine hydrochloride, it puts holes in the cell membranes of fungal cells, and can destroy fungi. Despite this, Lamisil has many problems such as harmful side effects, and a high cost, and can therefore be vastly improved. Some of Lamisil’s competitors, such as Tinactin, offer a similar medication for a cheaper price, and other analogs of the drug could prove to be safer and even more effective. For now though, Lamisil, the 87th best selling prescription drug in the world, is the best antifungal medication1.
Dermatophytes are parasitic fungi that infect the skin, causing athlete’s foot, ringworn, jock itch, and onychomycosis among other problems. These can result in dryness, itchiness, peeling skin, extreme discomfort, and discoloration of nails. Lamisil is a cure for all of these problems. Lamisil is made with the active ingredient terbinafine hydrochloride (C21H26ClN) 2:
3
Terbinafine hydrochloride is a white, crystalline powder that is sold as Lamisil in tablet, cream, and powder form. It is soluble in methanol, methylene chloride, ethanol, and is slightly soluble in water. It works by inhibiting squalene monooxygenase (formerly known as squalene epoxidase) an enzyme that creates sterols for a fungal cell membrane, a part of the fungal cell wall synthesis pathway. Therefore, ergosterol synthesis, or the building up of the fungal cell membrane is disrupted, causing the cell to lose its parts, and die. This only takes place in fungal cells, so human cells are not killed. Through this, terbinafine can kill dermatophytes, effectively. In tests, 59-79% of participants reported that their treatment with Lamisil was effective4.
Despite this, there are a variety of problems associated with Lamisil. The first problem is the cost. Lamisil is an expensive, prescription drug, and costs can run into thousands of dollars if used for a long time. Furthermore, many insurance companies don’t cover fungal problems, and tell their customers to use cheaper, over-the-counter alternatives. Secondly, there are a number of side effects associated with Lamisil. While the drug is relatively safe, there are dangerous qualities. Liver failure, causing death or liver transplant, has occurred for people both with and...

Find Another Essay On Effectively Treating Fungal Problems with Terbinafine Hydrochloride

Antibiotics used with Scaling and Root Planing

1430 words - 6 pages Localized Antimicrobial Adjuncts to SRPLocalized Antimicrobial Adjuncts to SRP in Treating Periodontitis Introduction Comment by Owner: This did not need to be here. You could have gone right to the introductionThe topic chosen for further research was localized delivery of antibiotics that are available for hygienist in conjunction with scaling and root planning and its effects on microbes. It is well researched that clinicians leave deposits

Tomato Diseases Essay

2109 words - 8 pages the soil. The fungus does not grow at temperatures below 68 oF.; it requires abundant moisture for growth. Infection takes place below the soil line or close to ground level. Control is obtained by sanitation, crop rotation, and by treating infected soil with a soil fungicide prior to planting. Seedling Disease Causal Agent(s): (fungal - Rhizoctonia sp., Pythium sp.) Seedlings fail to emerge or small seedlings wilt and die soon

Effect of natural penetration enhancers on dermal delivery of hydrocortisone acetate

1432 words - 6 pages –985. Baden HP, Gifford AM (1970) Isometric contraction of epidermis and stratum corneum with heating. J InvDerm54: 298-303. Barot BS, Parejiya PB, Patel HK, Gohel MC, Shelat PK (2012) Microemulsion-based gel of terbinafine for the treatment of onychomycosis: optimization of formulation using D – optimal design. AAPS PharmSciTech13: 184-92. Berker(2013) T Development of formulation for treatment of atopic eczema.http

Bacterial and Viral Infections

1698 words - 7 pages Bacterial and Viral Infections Being part of the Sports Medicine profession, Athletic Trainers have to be ready for anything and everything when it comes to treating their athletes. This includes recognition, evaluation, education and prevention of various problems. One specific aspect of this is having a basic knowledge of contagious diseases that is seen all too commonly in Athletics. Some examples of this include Tinea Pedis

The Many Faces of Evil: The Good Son

2874 words - 11 pages significantly reducing fighting, bullying, and explosiveness in children with CD. According to researcher Naruse, pimozide is noted to be as effective as haloperidol in treating bullying, fighting, and explosiveness in a heterogeneous sample of children (Naruse et al, 1982). Furthermore, molindone hydrochloride and thiorazine effectively reduced aggressiveness, hyperactivity, and hospitality while improving social responsiveness in a sample of 21

Zoonotic Diseases and Risk Factors

1456 words - 6 pages The purpose of this paper is to focus on a subject within my educational field that I can research and inform the public about. I plan to become a veterinarian .which would require my daily contact with humans and animals. Zoonotic diseases are risk factors that I have to be aware of in order to protect myself as well as my patients and their owners. Luckily developments in medicine have made it possible to cure zoonotic diseases and even

Fungal Infections in Immunocompromised Hosts

1217 words - 5 pages Fungal infections in immunocompromised host are common and are associated with significant mortality and morbidity. These are either endemic- caused by ubiquitous fungi such as: Histoplasma capsulatum and Mucor spps or opportunistic fungi such as: Candida species, Aspergillus species, pneumocystic jirovecii and Cyptococcus neoformans. Opportunistic fungal infections are the most common fungal infections seen in immunocompromised and are

1368

710 words - 3 pages metabolic abnormalities associated with HIV disease and gestational diabetes5,6,7. Metformin’s negligible risk of hypoglycemia in monotherapy and few drug interactions of clinical relevance give this drug a high safety profile. Metformin hydrochloride is an oral anti hyperglycemic agent used to treat patients with type II diabetes mellitus and it is a first drug of choice in majority of type II diabetic patients. Metformin is chemically (N-N

The Compounding Medicine Controversy

1251 words - 6 pages . Independent pharmacists also compound, shown by a survey in which “76% were seen to compound medicines for patients” (“International Academy of Compounding.”). The independent pharmacists, unfortunately, tend to have the most problems with compounding. In the last 3 years, there has been one major issue that was a direct result of compounding medication. The New England Compounding Center (NECC) was at the center of a 2012 outbreak of fungal meningitis

Virulence Factors and Evasion of the Human Defense System of Fungus

1567 words - 6 pages microorganisms, but also any undesirable material - such as the remains of billions of cells that die via apoptosis or necrosis daily - and immune networks from within. It is a rise in capability of microbial pathogens to resist antibiotics and anti-fungal medicines that remains a crucial component in understanding and treating major infections worldwide, primarily in hospital settings where a patient’s immunity is lowest due to already present illnesses

Social Anxiety Disorder

2046 words - 8 pages phobics had alcohol related problems” (Rachman 138). In seventy- five to eighty percent of patients with a comorbid psychiatric disorder, social anxiety disorder actually preceded that disorder. It is extremely important to screen for comorbidity because unrecognized depression and anxiety comorbidity is associated with an increased rate of psychiatric hospitalizations, and an increased rate of suicide attempts (Hirschfeld 6). Self-treatment methods

Similar Essays

Onychomycosis Essay

1242 words - 5 pages Onychomycosis Fungal infections are often uncomfortable conditions and they can have both physical and psychological consequences to the individual. Onychomycosis (OM) is one of the fungal diseases that results from a dermatophytic invasion of the nails. Fortunately, in the last few years, new oral treatment has successfully lowered the incidence of recurrence and side effects (Tosti & Piraccini

Cocaine Facts Essay

822 words - 3 pages Cocaine Facts Crack Crack is actually a less pure sort of free-base cocaine. Unlike old-fashioned free-base, however, its production doesn't involve any flammable solvents.  Crack is usually made by mixing two parts of cocaine hydrochloride with one part baking soda in about 20 ml of water. The solution is then heated gently until white precipitate form. Heating is halted when precipitation stops. The precipitate is filtered and

Opportunistic Fungal Infections Essay

1133 words - 5 pages Fungal infections are either opportunistic or endemic ubiquitous fungi that exist freely in the environment cause endemic fungal infections. On the other hand, opportunistic fungal infections only cause disease when the immune system degrades [1]. Opportunistic fungi are commensal with the host and a very low intrinsic virulence to cause until the immunity is altered. Some of these include: Candida species, Aspergillus species

Effects Of Glyphosate On Living Organisms

853 words - 3 pages Effects of Glyphosate on Living OrganismsGlyphosate is a type of broad spectrum, non-selective systemic herbicide. In other words it kills all plant types. However it is mostly targeted at types of weeds like grasses and deep rooted woody plants. It is the most widely used herbicide in the US in treating crops, forests, bodies of water, and public and private yards.Its molecular formula is C3H8NO5P with a structure of:This chemical has multiple