Effectively Treating Fungal Problems With Terbinafine Hydrochloride

1341 words - 5 pages

Terbinafine Hydrochloride: Effectively Treating Fungal Problems


Lamisil, which is chemically terbinafine hydrochloride, is the premier antifungal drug on the market. It effectively destroys fungal problems ranging from athlete’s foot to onychomycosis. However, Lamisil has a number of problems associated with it, including cost, side effects, and even effectiveness. Therefore, I created two analogs in an attempt to improve Lamisil, which I will discuss in my paper.

Plenty of fungal problems exist, including athlete’s foot, jock itch, ringworm, and onychomycosis (fungal infection beneath nails). However, many antifungal drugs exist as well, such as Lamisil, which is the most effective. Using the molecule terbinafine hydrochloride, it puts holes in the cell membranes of fungal cells, and can destroy fungi. Despite this, Lamisil has many problems such as harmful side effects, and a high cost, and can therefore be vastly improved. Some of Lamisil’s competitors, such as Tinactin, offer a similar medication for a cheaper price, and other analogs of the drug could prove to be safer and even more effective. For now though, Lamisil, the 87th best selling prescription drug in the world, is the best antifungal medication1.
Dermatophytes are parasitic fungi that infect the skin, causing athlete’s foot, ringworn, jock itch, and onychomycosis among other problems. These can result in dryness, itchiness, peeling skin, extreme discomfort, and discoloration of nails. Lamisil is a cure for all of these problems. Lamisil is made with the active ingredient terbinafine hydrochloride (C21H26ClN) 2:
Terbinafine hydrochloride is a white, crystalline powder that is sold as Lamisil in tablet, cream, and powder form. It is soluble in methanol, methylene chloride, ethanol, and is slightly soluble in water. It works by inhibiting squalene monooxygenase (formerly known as squalene epoxidase) an enzyme that creates sterols for a fungal cell membrane, a part of the fungal cell wall synthesis pathway. Therefore, ergosterol synthesis, or the building up of the fungal cell membrane is disrupted, causing the cell to lose its parts, and die. This only takes place in fungal cells, so human cells are not killed. Through this, terbinafine can kill dermatophytes, effectively. In tests, 59-79% of participants reported that their treatment with Lamisil was effective4.
Despite this, there are a variety of problems associated with Lamisil. The first problem is the cost. Lamisil is an expensive, prescription drug, and costs can run into thousands of dollars if used for a long time. Furthermore, many insurance companies don’t cover fungal problems, and tell their customers to use cheaper, over-the-counter alternatives. Secondly, there are a number of side effects associated with Lamisil. While the drug is relatively safe, there are dangerous qualities. Liver failure, causing death or liver transplant, has occurred for people both with and...

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