Elucidating The Role Of Adhesion Factors In Circulating Tumor Cell Clustering For Breast Cancer Metastasis And Venous Thromboembolism

667 words - 3 pages

A. Background: Breast cancer has now become a disease which, in most cases, is easily treatable if detected early or non-aggressive. However, the major cause of death for patients with breast cancer is metastasis of tumor cells from the primary tumor to secondary sites throughout the body. Determining the hallmarks to differentiate aggressive tumors versus non-aggressive tumors will not only in how clinicians choose to initially treat the patients, but also could potentially be used as therapeutic targets to specifically target metastatic tumor cells. Determining the factors involved in allowing circulating tumor cells to adhere to each other and to blood vessel walls could lead to improved treatment options for patients with metastatic breast cancer. However, paclitaxel has been shown to be ineffective for treatment of metastatic breast cancer. Proteins associated with the pericentriolar material (PCM) have been recently implicated as having major roles in microtubule nucleation and localization of some of these proteins has been shown to have changed in breast tumor cells versus normal cells. Thus the study of the proteins involved in the initial event of microtubule nucleation and the steps immediately following nucleation and how their interactions deviate from normal cellular activity could reveal crucial molecular biomarkers to treat metastatic breast cancer.

B. Rationale: We seek to study the process of microtubule nucleation in various breast tumor cell lines of diverse metastatic potential and understand the role of abnormal microtubule nucleation in breast cancer metastasis. Preliminary studies from our lab have shown a dissimilar staining pattern by immunofluorescence in the major microtubule nucleating protein, γ-tubulin, as compared with normal cells. Furthermore, other proteins involved in microtubule nucleation, anchoring, and localization have been shown to have differential expression in increasingly metastatic breast cancer cell lines.

C. Objectives: 1) Does the incidence of aberrant microtubule nucleation increase in breast tumor cell lines? Recent preliminary data in our lab has confirmed the occurrence of microtubule nucleation...

Find Another Essay On Elucidating the role of adhesion factors in circulating tumor cell clustering for breast cancer metastasis and venous thromboembolism

Stem Cell Research and Breast Cancer

1481 words - 6 pages cells to treat breast cancer. Non-embryonic stem cell are only believed to be able to develop into the type of cells that they originated from, limiting their use. Scientists believe that embryonic stem cells have the potential to be manipulated into a wider variety of needed cells. Cells that can be used to treat breast cancer effectively and prevent it for good. The problem is that in August of 2001, our government banned the scientific

Breast Cancer: Risk Factors and Treatment

1840 words - 7 pages (Braddock, Suzanne W.). Your risk of developing breast cancer will increase as you get older, it is uncommon for a young girl to have breast cancer, but it is more common for a forty year old woman to be diagnosed with breast cancer. Age plays a very big part in the risk factors of breast cancer (Risks and Prevention). Being female also affects your risk of getting breast cancer. Being female is the most important risk factor for getting breast cancer

"The Role of the Media in the Public Understanding of Health Issues" Breast cancer & Silicone implants

2020 words - 8 pages In this paper, the writer shall debate the issue of whether or not the media play a significant role, in contributing to the publics' education of breast and other cancers, due to silicone gel breast implants, and the strategies used, if any, to promote public awareness. The reason for the writer's interest in this subject is that writer had silicone breast implants, which leaked, whereupon a second operation was undergone to remove them. The

The Issues of Breast Cancer in Nigeria

1616 words - 6 pages responsible for about 10% of breast cancer deaths. At this stage, the health sector comes in to play a great role. Doctors should try to emphasize the importance of exercise, healthy eating and moderate alcohol intake to all patients at hospitals. An article presented online by the WHO states: As part of the ongoing Black Women's Health Study, a recent research was particularly focused on foods that help lower the risk of estrogen receptor-negative (ER

Tracking Metastasis and Tricking Cancer

1329 words - 5 pages Carcinoma is a cancer that begins to develop in epithelial cells. These cells include the lining or tissue of an organ or in the skin (Australian Institute of Health Welfare & Australasian Association of Cancer, 2012). There are two types of carcinoma cells, basal cells and squamous cells (American Cancer Society, 2012). Basal cell carcinomas are the cells that develop in the basal cell layer of the epidermis (American Cancer Society, 2012

The Use of Telomerase in Diagnosis, Prognosis, and Treatment of Cancer: With a Special Look at Breast Cancer

2613 words - 10 pages . There are actually many potential blockers, but only a few have all the desired characteristics such as being harmless to the cell and completely inactivating telomerase. The leading inhibitor is called AZT and has been successful at stopping breast cancer cell growth but its entire function remains not fully understood (Herbert 2001).Telomerase plays a vital role in cell biology and acts as great mechanism of avoiding telomere shortening. For

Overview of the Treatment of Breast Cancer

2269 words - 9 pages , M. H., Dodd, M. J (2011). Nutritional symptom and body composition outcomes of aerobic exercise in women with breast cancer. Clinical Nursing Research, 20 ,1, 29-46, doi: 10.1177/1054773810379402 Groff, D., Battaglini, C., Sipe, C., O'Keefe, C., Peppercorn, J (2009). Lessons from breast cancer survivors: the role of recreation therapy in facilitating spirituality and well-being. Journal of the Canadian Association for Leisure Studies, 33,1, 341

Evaluation of Depression and Breast Cancer

7053 words - 28 pages ) Anxiety and depression was reported in up to 25 % of women with advanced breast cancer: on third of the cases may be persistent (Pinder, 1993).One of the unique features of breast cancer is its relationship to the precipitating factors for the disease. What is it specifically about a diagnosis of breast cancer that places a woman at risk for depression? Gaining insight into potential mechanisms that can contribute to enhancing quality of life by

The Most Common Cancer in the UK: Breast Cancer

2309 words - 9 pages on the surface of breast cancer cells, this means that the cell is stopped from being able to grow along with encouraging the body’s immune system to fight off the cancer cells. Herceptin is given every three weeks for a year and it can be given alongside receiving chemotherapy treatment as well as on its own after the other treatments have finished. It is given by an injection through a cannula into a vein which will take place in the

New Treatments for Breast Cancer

2497 words - 10 pages has no distant metastasis. The fourth and final stage of breast cancer includes a tumor that has distant metastasis. The survival rates for each of these stages include 85% for stage one, 66% for stage two, 41% for stage three, and 10% for stage four (Feldman). At the present, clinical research in breast cancer is focusing on a variety of promising theraputic strategies, such as new chemotherapy agents, endocrine agents, antibody therapy

The cell and Neoplasm (cancer)

1998 words - 8 pages for a particular neoplasm, which will be cancer of the skin.Every cell performs many different tasks to survive and consists of many organelles which all have their own part to play in the function of the cell. Endoplasmic reticulum is a network of tubes mainly used for protein synthesis and breaking down toxins, there are two types of endoplasmic reticulum: smooth and rough, it is known as rough because it has ribosomes attached to it. Ribosomes

Similar Essays

Cancer Cell Metastasis And How Cells Diffuse Into Diverse Parts Of The Body

947 words - 4 pages activity of tumor cells and how they evade has therefore been to study how signals can direct the cells to different parts of the body. In normal circumstances, cells are able to bind to one another as well as form an extracellular matrix. Different types of adhesion can function as a critical role in metastasis and tissue invasion. It is thought that cell-to-cell adhesion, which is common in normal tissue, is not a characteristic of cancer cells.Tumor

The Risk Factors Of Breast Cancer

1557 words - 6 pages chances for this disease are amplified (Breast Cancer Risk Factors, 2010). The risk for this disease is another reason to kick the smoking habit. On top of breast cancer, a person’s lifestyle also plays a role in many other cancers, so it is imperative to try and live healthy lifestyles. As research shows, having hereditary genes is only one of the many risk factors linked to breast cancer. These risk factors: age, family

Role Of Social Support In Breast Cancer

2243 words - 9 pages others who are experiencing the same illnesses as them. Yoo and her colleagues examined the role of computer-mediated social support in their study “Giving and Receiving Emotional Support Online: Communication Competence as a Moderator of Psychosocial Benefits for Women with Breast Cancer”. Specifically they found that computer mediated social support groups are beneficial to patients well being, but only for a certain personality type (Yoo et al 2014

Tumor Protein 53 And Its Role In Ovarian Cancer

3174 words - 13 pages suppressor p53). Another main role p53 plays is as a tumor suppressor and once activated, protects against cancer by “functioning as a sequence-specific transcription factor, through protein-protein interactions, activating cell cycle arrest, apoptosis, and DNA damage repair (Brachova).” As one of the most common tumor suppressor genes, TP53 is associated with almost every cancer, making it one of the most complex and most studied genes in the