This website uses cookies to ensure you have the best experience. Learn more

Fourier Transform Raman Spectroscopy: Solid Sample Analysis

1887 words - 8 pages

Historical Development of FT-Raman Spectroscopy

Preliminary Information of FT-Raman Development

Throughout the historical development of innovative instrumental techniques, the aim has always been to make improvements that would allow for a greater yield of accuracy to be achieved in a given assay, more precision within measurement, and a higher capability of detectability. With that being said, this aim towards improvement was the driving force that resulted in the development of many sophisticated analytical techniques today. However, in reference to the development of FT-Raman spectroscopy, there was an exception. This anomaly was due to the fact that the practices governing this field of study were what led to the rediscovery of this technique. Also, the fleeting rise to popularity of FT-Raman spectroscopy in analytical studies is as a result of underlying technology behind this technique [1].

Pioneering Experiments by Chantry et. al and Chase

The first known knowledge of an experiment being performed to analyze Raman scattered light using an excitation source in the near-infrared region coupled with an interferometer for spectral analysis was from a paper published in Nature, 1964by Chantry et al. [1-4]. In this article they go on to explain how strongly colored substances cannot be successfully examined exclusively with the use of Raman spectroscopy. This argument is based on the conception that the use of ultra-violet and visible lasers will not allow Raman spectra to be measured from these substances. However, they also noted that in the near infrared region, virtually all compounds have some degree of transparency. Therefore, they suggests that the method of circumventing this problem in examining these colored substances would be to develop a technique that comprises the use of near infrared lasers that will produce these transparent regions, which will enable Raman spectra to be measured. Their main experiment to implement this suggestion involved measuring the Raman scattering from an iodine solution dissolved in both carbon tetrachloride and a carbocyanine dye in methanol using a Michelson interferometer [3,4].In performing this experiment, they were able to demonstrate the feasibility of analyzing and obtaining Raman measurements from a solution containing such a dark pigmentation [1,3, and 4]. Granted, the results were minimal and based on the observations of broad bands, it was clear that there were still severe limitations with this technique [1, 4]. To explain, the lasers that were used in this experiment were extremely noisy. Also in using the detectors that were available to them they could only achieved poor instrumental resolution, which was not ideal [1, 3 and 4]. In addition to the instrumental limitations, the fluorescence interference caused by impurities or from the analyte itself also attributed to the poor analysis results, as well as the low number of Raman measurements acquired [4, 5]. However, this...

Find Another Essay On Fourier-Transform Raman Spectroscopy: Solid Sample Analysis

Spectroscopy Essay

1235 words - 5 pages has been emitted, reflected or scattered from a solid, liquid, or gas. Fundamentals of Spectroscopy Spectroscopy is the distribution of electromagnetic energy as a function of wavelength. Spectrum is basically white light dispersed by a prism to produce a rainbow of colours; the rainbow is the spectrum of sunlight refracted through raindrops. All objects with temperatures above absolute zero emit electromagnetic

Development of ketoprofen loaded proliposomal powders for improved gastric absorption and gastric tolerance: in vitro and in situ evaluation

616 words - 3 pages dissolution efficiency (DE) (27) at 5 and 60 min, initial dissolution rate (IDR), mean dissolution time (MDT), mean dissolution rate (MDR) and relative dissolution rate (RDR) (28). Solid state characterization Fourier transform infrared spectroscopy (FTIR) FTIR analysis was executed to assess any possible interactions that might have occurred between ketoprofen and other excipients during the formulation. The infrared spectra of ketoprofen

The tribological behaviour of water dispersion of diamond nanoparticles between sintered tungsten carbide ball and stainless steel plate

1317 words - 6 pages the wear profile for SUS304 which revealed the condition of post-test wear track such as surface condition, wear profile and the depth of the wear. Lastly, the Raman spectroscopy was conducted as standard characterization technique for the carbon system to investigate any formation of carbon composites including DNP or graphite after the sliding test along wear track and the wear of ball[16].  Works Cited [1] Bartz WJ. Lubricants and the

Natural Biopolymer Materials Carboxymethyl Cellulose Based Protonic Conducting Biopolymer Electrolyte and Application in Rechargeable Protonic Battery

642 words - 3 pages characterized by Fourier transform infra red (FTIR), Thermo Gravimetric Analysis (TGA), electrical impedance spectroscopy (EIS) and transference number measurement (TNM). In order to determine the potential of the highest protonic conducting BPE as an electrolyte system in battery, it was used in the fabrication of Zn + ZnSO4•7H2O/BPE/MnO2 protonic battery.

Development of isradipine loaded self-nano emulsifying powders for improved oral delivery: in vitro and in vivo evaluation

927 words - 4 pages Solid state characterization Fourier transform infrared spectroscopy (FTIR) FTIR spectra of the samples i.e. ISR, neusilin and optimized SNEP was recorded in the scanning range of 4000–400 cm-1 using FTIR Spectrophotometer (Paragon 1000, Perkin Elmer, USA) to illustrate the possible interactions between the drug and the carriers used in the formulation. Lightly ground mixture of formulation sample (4 mg), dry potassium bromide (IR grade; 200 mg

self emulsifying drug delivery system of docetaxal

642 words - 3 pages transform infrared spectroscopy (FTIR) FTIR spectrum of the samples was recorded by KBr disc method using Perkin Elmer FT-IR Spectrometer (Paragon 1000, PerkinElmer, Waltham, Massachusetts, USA) to illustrate the promising interactions among the components used in the formulation. Powder sample (4 mg) and IR grade dry potassium bromide (KBr; 200 mg) were mixed gently in a glass mortar, compacted to form disk by applying a force of 5.5 metric tons using hydraulic press. The corresponding disks were scanned over the wave number range of 4000–400 cm-1 at a scanning speed of 4 scans /s with a resolution of 1 cm-1 for each spectrum.

Provesicular Dry Powder Formulations for Pulmonary Delivery of Anti-tubercular Drugs

1815 words - 8 pages collected and analyzed by photon correlation spectroscopy and turbidimetric measurement at 650 nm. Solid state characterization Fourier transform infrared spectroscopy (FTIR) FTIR analysis is executed to assess any possible interactions that might have occurred between drug and other components of the formulation. The infrared spectra of pure drug, free components of provesicular formulation and optimized provesicular powder formulation are

A comparative study on varied potentials of Aspergillus species in synthesis of silver nanoparticles

702 words - 3 pages hydrodynamic size of the silver nanoparticles was obtained using a Zeta-sizer (Malvern) instrument applying a 660 nm laser. The software was optimized to report summary statistics based upon the intensity of light scattered. Two milliliter sample volumes from each nanosilver dispersion were loaded into glass cuvettes and summary statistics were obtained using triplicate 2 minutes analyses (total analysis time=6minutes). For Fourier transform infrared

ntegration of Nano-Dielectrophoretic Bacteria Capture and Surface-Enhanced Raman Detection

1634 words - 7 pages continual increase in the brightness as more bacteria are trapped with time. Hence, increase in the integrated fluorescence intensity (Δ F), before and after capture, is used for the data analysis. The lab setup of microfluidic device under confocal Raman microscope and portable Raman microscope is shown in Supplementary Information fig 1 a and b. TEM images of IO-Au-SERS-NOVs and bacteria functionalized with these nano-ovals are shown in

Ground State Potential Energy Curve And Dissociation Energy Of MgHâ€

1336 words - 5 pages , P. F. Bernath (2007). "Ground State Potential Energy Curve and Dissociation Energy of MgH". The Journal of Physical Chemistry A 111 (49): 12495. Robert D. E. Henderson, Alireza Shayesteh, Jason Tao, Carl C. Haugen, Peter F.Bernath, and Robert J. Le Roy, (2013). Accurate Analytic Potential and Born–Oppenheimer Breakdown Functions for MgH and MgD from a Direct-Potential-Fit Data Analysis. The Journal of Physical Chemistry A2013 117 (50), 13373-13387 Shayesteh, A.; Appadoo, D. R. T.; Gordon, I.; Le Roy, R. J.; Bernath, P. F. (2004). Fourier transform Infrared Emission Spectra of MgH and MgD. J. Chem. Phys. 120, 10002−10008.

Breath Analysys

908 words - 4 pages to certain diseases. Due to very low concentration of VOCs the breath analysis requires an instrument with high sensitivity. There are some simple methods for specific purposes but mainly the analysis is done by using different forms of spectroscopy. One of the main techniques used is gas chromatography-mass spectroscopy (GC-MS). MS based techniques have a good sensitivity, but they are time-consuming, involve difficult sample detection and the

Similar Essays

Fourier Transform Raman Spectroscopy Essay

1299 words - 6 pages visible region due to thermal effects, the sample would have to be heated to an extremely high temperature to produce black-body emission. However, in the near infrared region, even the slightest degree of heat can cause background emission. 3.3 Noise Distribution Noise distribution is a factor that is only unique to Fourier transform spectroscopy as opposed to dispersive Raman measurements in the visible region. The reason being is because in FT

Experiment 1: Ir Unknown/Spectroscopy Assignment Fourier Transform Infrared Spectroscopy

2725 words - 11 pages Purpose: The purpose of this experiment is to practice the usage of infrared spectroscopy and to identify the unknown compound # 53 using Fourier-Transform Infrared Spectrometer. From the IR spectroscopy, specific functional group peaks are noted and used to aid the identification of the unknown organic compound. Furthermore, in this experiment, another unknown will be given and researched upon its spectral data.Main Reaction: There is not

Decorative Glasses Essay

1543 words - 6 pages -styled architectures in northern Thailand [3-5]. It was well known that Raman spectroscopy was a powerful tool for the analysis the archaeological glasses both for surface weathering study and bulk structure characterization [2, 6]. In this study, fragments of the ATG samples that broke with deterioration over time and fall down to the ground from the Buddhist temples at Phra Nakhon Sri Ayuttaya Province, central Thailand were analyzed

Role Of Acidic Media In Architecting Of Ammonia Gas Sensing Behavior Of Polypyrrole Nanostructures

2106 words - 8 pages Chem. 547 (2003) 75-82. [29]. Y. Liu, W. Hwang, W. Jian, R. Santhanam, In-situ cyclic voltammetry-surface-enhanced Raman spectroscopy: studies on the doping–undoping of polypyrrole film, Thin Solid Film 374 (2000) 85-91. [30]. J. Duchet, R. Legras, S.D. Champagne, Chemical synthesis of polypyrrole: structure–properties relationship, Synth. Met. 98 (1998) 113-122. [31]. J. Arjomandi, A.H.A. Shah, S. Bilal, H.V. Hoang, R. Holze, In situ-Raman and