Gaining Control Of The Gene Responsible For Apoptosis

1199 words - 5 pages

Gaining Control of the Gene Responsible for Apoptosis

When we gain control of the gene responsible for the phenomenon of apoptosis, we will be in control of aging. We are finding more evidence every day, indicating genetic links to all sorts of factors in the human being. We are just now beginning to scratch the surface of our own genetics. A landmark discover has just been unveiled: In February [2001], the two groups charting the human genome published their results—the entire 3 billion base pair sequence. The only definitive conclusion so far: Humans are far more complicated than we thought. …Eric Lander, director of the Whitehead Center for Genome Research in Cambridge, Massachusetts … adds: “within a decade, we will understand a lot about the causes of diseases. Understanding, however does not translate into cures.” (Sinha 43)

With this research we will uncover more factors that our genetic code regulates, many factors that were previously believed to be random events. Spontaneous cell death, as it turns out is not spontaneous at all, but genetically predetermined at conception.
Cell death is an essential part of life. The cells in our bodies are constantly dividing, producing hundreds of thousands of new cells every second. To maintain balance, for every new cell, another cell must die. Our cells are programmed to kill themselves through a process called apoptosis. This in-built program of cell suicide prevents cancer by eliminating cells with damaged genes (Cotran 18). Similarly, our bodies replace cells with a new type of cell when a change is needed, such as during embryonic development (Cotran 18). To illustrate this point, we look at one of Dr. Adamchak’s “stories of physiology,” as taught from Martini, when a bone is being formed cartilage cells, or condrocytes, come into an area to build a cartilage model of the bone. Once this model of bone is complete, the cartilage cells are given the command to die. Osteoblasts, or bone building cells, move in to the space formerly occupied by the Condrocytes, and replace the cartilage matrix with a Calcium rich, rock hard, matrix, we know as bone (188). In the foregoing example there are instances of cells being told to die, this is programmed death, and known as apoptosis.

During life, our cells carry out metabolic functions, producing digestive enzymes and waste products, which are harmful to surrounding cells, if it spewed into the fluids among the cells. These enzymes and toxins must be packaged in a way that is not harmful to the interstitial environment, and in a manner in which appropriate cells in the region can readily absorb them. This must be done without invoking an inflammatory response (Browder).

Aging, also known as Senescence, is a natural process, “beginning at reproductive fitness and culminating in death,” Observed in most living organisms, senescence is characterized by a gradual reduction in “reserve capacity of organ systems”,...

Find Another Essay On Gaining Control of the Gene Responsible for Apoptosis

Physical and functional interaction of the proto-oncogene EVI1 and tumor suppressor gene HIC1 deregulates Bcl-xL mediated block in apoptosis

650 words - 3 pages transfected cells. Also to support the above result further pECFP-N1-EVI1 was transfected with pEYFP-N1 vector control and pEYFP-N1-HIC1 with pECFP-N1 vector control and in both the cases no FRET pairing was observed (fig. 2B). This confirmed the interaction of EVI1 and HIC1 in mammalian cells. 3.2 The first zinc finger domain of EVI1 and N-terminal BTB/POZ domain of HIC1 are critical for efficient interaction Both the transcriptional regulators

The Importance of Gaining Knowledge Essay

1009 words - 5 pages important aspect out by commenting, “Textbooks’ treatment of events in …. history are never anchored in any analysis of social class” (Loewen 202). This comment underscores his personal beliefs that social class has a key effect on power, and even deeper, on gaining knowledge. Desiring knowledge is the primary step to gaining power. The secondary step is wanting to use power for beneficial outcomes. Both Douglass and the Count of Monte Cristo remark

Was Martin Luther King vital to the gaining of civil rights for African Americans?

1993 words - 8 pages of our childhood."Word count: 332Section 2Using the sources below and your own knowledge discuss: "Martin Luther King was vital to the gaining of civil rights for African Americans"Martin Luther King was a great contributor to the black civil rights movement and a key player. Through his use of non-violent protest and excellent speeches he was able to garner the support of both African Americans and whites alike. However despite his astounding

For the Love of Food : Who is responsible for weight?

1427 words - 6 pages 259-288). Food at these [“fast food” restaurants] is generally high in energy density-the energy content per unit weight-and fat, while providing few nutritional benefits (Davis 259-288). The high energy density of the fast food thus “challenges our appetite control systems with conditions for which they were never designed.” A typical meal at a fast food restaurant may account for over eighty percent of the recommended daily allowance for fat

Who was responsible for the downfall of the first triumvirate

1517 words - 6 pages the others. We will look at the reasons and circumstances that each of these three men played in the downfall of the triumvirate and the way their careers advanced or were halted. We will look at Caesar the popularis, Crassus the spokesperson for the people and lastly Pompey, the great military general.Due to his alliances with Pompey and Crassus, Caesar received his first consulship in 59 BC. In these early days of the triumvirate the alliance

Environmental Factors Responsible for the Disappearance of the Drooping Trillium

2607 words - 10 pages Drooping Trillium. It may give us information that will lead us to attempt to control the population of white-tailed deer or Garlic Mustard in order to preserve the Drooping Trillium. I did not focus on the effects of habitat loss because that has already been studied, and it is well known that this has led to the population losses for the Drooping Trillium. There is also protection acts in place for this species from habitat destruction and loss. I

Applying Autophagy and Apoptosis for Strategies to improve treatment of Glioblastoma

707 words - 3 pages role as a tumor suppressor. Beclin-1 forms a multimeric complex with Atg14, Vps34/class 3 phosphatidylinositol 3--‐kinase (PI3k), and Vps15; the formation of this complex is necessary for the formation of the autophagosome and contributes to the regulation of autophagy. The human Beclin-1 gene is monoallelically deleted or is underexpressed in breast, ovarian, prostate, and gastric cancer, and most malignant brain tumors. Reduced expression

The Idealization of Women is Responsible for Tragic Endings

1021 words - 5 pages Othello, Desdemona and Daisy are both responsible for their tragedies due to the manipulation and impact of the outsiders, their loss of innocence, and their vulnerability as women. The outsiders, Tom and Iago become influential puppeteers, as Daisy and Desdemona are their puppets. Their influences on each of the female protagonists, results in inevitable tragedy. In Othello, the antagonist Iago has a strong bitter hatred towards Othello. He

Who Is Responsible For The Death Of Romeo And Juliet?

1563 words - 7 pages Who Is Responsible for the Death of Romeo and Juliet?“Love is like a violin. The music may stop now and then, but the strings remain forever.” –Anonymous“Hatred does not cease through hatred at anytime. Hatred cease through love. This is an unalterable law.” –BuddhaLove and hatred are defined as two extremely opposite terms literally; however, they are combined perfectly to provide the prerequisites of the tragic

Friar Laurence: Responsible For the Deaths of Romeo and Juliet

768 words - 4 pages Responsibility means being held accountable or to blame for an act. In many tragedies, there is one character to be held responsible for the unhappy end. In the case of the drama Romeo and Juliet, written by William Shakespeare, Friar Laurence is responsible for the deaths of the titular characters. Friar Laurence’s cowardice, unreliability, and impulsivity lead to the unfortunate deaths of Romeo and Juliet. Friar Laurence’s decisions made from

Who Is Responsible for the Death Of Romeo and Juliet?

846 words - 4 pages everybody (from the audience to Prince Escalus, himself) wondering of who is responsible for the unfair deaths of Romeo and Juliet. Who exactly is to be blamed for the deaths? With the rivalry between the Capulets and Montagues and the helping hand of Friar Lawrence, you can already say that these two are already, yet not entirely, to be held responsible for Romeo and Juliet’s deaths, however, when you look into the circumstance, you will see

Similar Essays

The Process Of Apoptosis Essay

2334 words - 9 pages more developed an organism is, the more complex their apoptotic systems are. Although the processes remain similar, more complex animals possess more proteins and other structures which regulate the apoptotic process (Twomey and McCarthy, 2005). Apoptosis occurs for a variety of reasons, beginning when an organism is in the embryonic state, up until the point of death. Most embryonic apoptosis is morphological (Joza, 2001) and is responsible for

The Gaining Of Power Essay

1393 words - 6 pages Traditional beliefs of women being weaker than men has made women live under the control of men for centuries. In the past, women's activities are quite restricted. Some of them were not allowed to go to school or even wandered on the street. But now the situation has been improved, women are actively gaining respect from various aspects, which is due to the allowance of education for women. According to New Internationalist , cabinet positions

Physical And Functional Interaction Of The Proto Oncogene Evi1 And Tumor Suppressor Gene Hic1 Deregulates Bcl X L Mediated Block In Apoptosis

662 words - 3 pages immunoprecipitation of the HIC1 deletion constructs while panel 3 and 4 shows the expression of EVI1 and HIC1 deletion constructs in whole cell extracts. 3.3 EVI1 and HIC1 colocalize in nuclear speckles Many nuclear factors involved in mRNA splicing, transcriptional regulation, apoptosis or cell cycle progression are localized in distinct structures called speckles or nuclear bodies (Lamond and Spector, 2003). In order to determine whether

Physical And Functional Interaction Of The Proto Oncogene Evi1 And Tumor Suppressor Gene Hic1 Deregulates Bcl X L Mediated Block In Apoptosis

731 words - 3 pages culture and then assayed for the occurrence of apoptosis using the Annexin-V-PE-7-AAD apoptosis detection kit (BD Biosciences, USA). After staining with Annexin-V-PE & 7-AAD as per manufacturer’s instructions, cells were analyzed using the FACS calibur platform (BD Biosciences, USA).