As the prime example of a post infection immune disease, Guillian-Barré syndrome proves to be a fascinating enigma despite today’s medical advances. The syndrome branches out into several pathological subcategories infamously including demyelinating disorder of peripheral nerves. Treatment has vastly improved leading to a low mortality rate but there is a high risk that a patient could remain disabled.
Before we get started, the syndrome was discovered in 1859 and Jean Landry was accredited but the research and diagnosis were done by Guillain, Barré, and Strohl in 1916. The three doctors were examining two soldiers severely ill with weakening muscles, paresthesia, and muscular pain. The soldiers were being examined by Georges Guillain but it was not until Strohl conducted an investigation in the spinal liquid and performed an electrophysiological test, did he espy pathology in the Achilles reflex and the quadriceps muscle. The condition of the soldiers ameliorated and were soon discharged from the hospital. Weeks after the case with Guillian, Baré, and Strohl, three cases were reported. After three months, all of the patients were discharged. It was not until 1927 when H. Dragonanesco and J. Claudion first called the disorder Guillain-Barré syndrome. To know what doctors are dealing with, they must know the symptoms.
First, the signs of Guillain-Barré Syndrome starts with symmetrical weakness in the lower limbs. The symmetrical weakness and strange sensations of paresthesia disseminates to the arms and upper body. There will be instability as patients often call rubbery legs, muscle weakness, and the dispersion of that weakness and stinging sensation. The muscle weakness progresses to oropharyngeal dysphagia, and most commonly, facial weakness. Sensory loss, although rare, appears in proprioception and complete loss of deep tendon reflexes, affecting coordination and movement. In more severe cases, there is a drop in blood pressure and acute paralysis which could be life threatening if muscles paralyzed interfere with breathing which in that case the patient would be required ventilator assistance. Although most patients recovery even with severe a case of Guillian-Barré syndrome, they are left a variation of weakness and in some cases, disabilities. The duration of the syndrome may be unbenounced and can very.
Initially, Guillian-Barré syndrome progresses over a period of time...