Hepatitis C (Hcv) Essay

3005 words - 12 pages

Hepatitis C (HCV), a single stranded RNA virus from the family Flaviviridae, now accounts for more disease and death that does human immunodeficiency virus HIV/AIDS. Approximately 3 million individuals within the United States are currently suffering from what was once and unknown and untreatable virus. Non-A and non-B hepatitis are two forms of the virus that were prevalent back in the 1970’s. It was commonly acquired via blood transfusion as well as through hemodialysis methods of renal failure patients (Klevens et al., 2012). Today, the most common means of transmission are through intravenous drug use, needle stick injuries in a health care setting, and transmission from mother to fetus during birth (Center for Disease Control and Prevention [CDC], 2013a).
Humans serve as the only natural host for Hepatitis C (Pawlotsky, 2004). They invasion of hepatitis C at the cellular level is not fully understood, but it is known that the virion infection is a multiphase process that includes virus entry, transcription of genomic RNA, translation of polyportein synthesis of negative strand RNA, followed by production of progeny genomic RNA and finally assembly and secretion of virons. When the virus invades the body, it targets the largest internal organ of the human body; the liver (Chang et al., 2012).
The liver is a functionally complex but a simple structure located on the right side of the body where it is attached to the diaphragm. It has two lobes with two blood supplies: the hepatic artery which takes in oxygen rich blood from the heart and the portal vein which supplies the liver with nutrient-rich blood from the digestive tract. These blood supplies merge into the sinusoids and then further to the hepatocytes and Kupper cells. The hepatocytes make up 80% of the liver and are associated with cell regeneration while the Kupper cells are macrophages lining the sinusoids and phagocytize foreign substances (Bishop et al., 2010).
The liver is involved in many functions of the body which are important for survival. It is the main filtering organ of the body and is involved in processes such a synthesis of plasma proteins, storage of glycogen for energy use as well as excretion, secretion and detoxification of products such as bilirubin, alcohol, cholesterol and drugs. Since the liver is the only organ to rid hemoglobin from the body, one of the most important functions it carries out is bilirubin metabolism. The heme component of hemoglobin is first converted to bilirubin by set of enzymes. It is then bound to albumin and transported to the liver hepatocytes where the enzyme uridyl diphosphate-glucoronyl transferase converts bilirubin into water soluble conjugated form so it can be excreted into the intestines. If the hepatocytes within the liver are damage due to invasion of HCV, bilirubin will not be able to be excreted thus resulting in the buildup of bile. When bile builds up, the skin turn to a yellowish color called jaundice. This usually...

Find Another Essay On Hepatitis C (HCV)

Hepatitis C Essay

922 words - 4 pages % for genotype 1, and 66% for genotype 2 and 3.CONCLUSION: I. Hepatitis C is very a deadly disease that must not be underestimated.A. It's good to be informed on what Hepatitis C is. B. Know what the symptoms are. C. Know that there are treatment available.II. You must keep in mind that Hepatitis C kills 8,000-10,000 Americans a year and that there are over 4 million Americans infected with HCV; It is better to be informed

Hepatitis C Essay

1831 words - 7 pages different forms of treatment, he has discovered that his body will tolerate none of the conventional medical treatments and he now manages his disease by diet and vitamin supplements to the best of his ability.Hepatitis C is a viral infection that usually attacks the liver but can manifest elsewhere.Until 1989, when HCV was identified, the remaining Hepatitis viruses were referred to as non /A non /B Hepatitis. This discovery of HCV prompted immediate

Surgeons and the Risk for HCV

963 words - 4 pages Imagine watching a surgery, seeing the hustle and bustle of nurses, technicians, and the surgeon trying to save the life of the person on the table. Suddenly, the controlled commotion just seen is replaced by horror when the surgeon suddenly cuts himself on a sharp edge of an appliance. The blood of the surgeon is now contacted with the blood of the patient. He is now at a greater risk for HCV. HCV, or Hepatitis C Virus, is transmitted through

Impact of host IL28B rs12979860, rs8099917 in interferon responsiveness and advanced liver disease in chronic genotype 3 hepatitis C patients

1663 words - 7 pages Chronic hepatitis C virus (HCV) infection is a major cause for developing cirrhosis and hepatocellular carcinoma (HCC), with an estimated global prevalence of 3% occurring in about 180 million carriers and more than 350,000 people die every year from hepatitis C-related liver diseases [1, 2]. According to World Health Organization reports, HCV is found worldwide with certain countries having chronic infection rates as high as 5% or above. In

Hepatitis C: The Potential Therapy for Hepatitis C

1724 words - 7 pages Introduction Hepatitis C is a chronic liver disease that is caused by an infection from hepatitis C virus (HCV). The hepatitis C virus is an RNA virus that belongs to the Hepacivirus genus of the Flaviviridae family (Lauer and Walker, 2001). Nearly 170 million people are chronically infected by this virus, which represents approximately 3% of the world population (Mohd Hanafiah et al., 2013). Chronic hepatitis C can lead to other serious liver

Coinfection of HIV, Hepatitis C virus, and Hepatitis B virus among Injection Drug users in Isfahan Drop in Centers

773 words - 4 pages programsreduction programs in mentioned centers but for achieving more favourable results harm reduction programmsprograms should be still expanded. Key words: HIV, hepatitis C virus, hepatitis B virus, coinfection, Drop in Center Introduction: Hepatitis B virus, hepatitis C virus (HCV) and Human immunodeficiency virus (HIV) are the three prevalent viral and blood bore infections worldwide (1).They considered as an important public health concerns due to

Association of genetic polymorphisms at IL28B amongst different disease groups and interferon responsiveness in chronic HCV patients from Eastern

1225 words - 5 pages Chronic Hepatitis C Virus (HCV) infection is a major cause for developing cirrhosis and hepatocellular carcinoma, with an estimated global prevalence of 3% occurring in about 180 million carriers and approximately 4 million people are being newly infected annually (1). According to WHO, HCV is found worldwide with certain countries having chronic infection rates as high as 5% or above. In India 12.5 million people are infected with HCV (2

Hepatitis C

1828 words - 8 pages of blood to transmit HCV (Dominitz et al., 2005). International Liver disease is the fifth largest cause of death in the UK. The main causes of liver disease are alcohol abuse, obesity and viral hepatitis. The health protection Agency (hpA) estimates that there are about 216,000 hepatitis C-positive people in the UK, however, only 85,000 people in England have been diagnosed and around 27,500 have received treatment recommended by the National

Hepatitis

585 words - 2 pages transmitted disease (STD). You can get hepatitis by having unprotected sex with an infected person, using (unsterile) needles and tools that were used on someone else such as drug needles and razors. An infected woman can give hepatitis B to her baby at birth or through her breast milk. Hepatitis C is caused by the virus HCV. It is spread the same way as hepatitis B, through contact with an infected person's blood, semen, or body fluid. Like

Tips for Managing Symptoms Associated with HCV

720 words - 3 pages Tips for Managing Symptoms Associated with HCV Based on the research made by the World Health Organization or WHO, every year 3 to 4 million people are infected by hepatitis C virus or HCV and more than 350,000 die every year because of this chronic disease. Fortunately, due to the introduction of direct-acting antivirals, treatment for HCV has been improved dramatically. Some of these medications have troublesome side effects that can

Seropositivity of hepatitis B and C among thalassemic patients in Sulaimani city

1260 words - 6 pages . Natl. Acad. Sci. U.S.A. 110 (20): 8194–9. 16. Kapoor A, Simmonds P, Scheel TK, et al. (2013)."Identification of rodent homologs of hepatitis C virus and pegiviruses". MBio 4 (2): e00216–13. 17. Op De Beeck A, Dubuisson J (2003). "Topology of hepatitis C virus envelope glycoproteins". Rev. Med. Virol.13 (4): 233–41. 18. Kato N (2000). "Genome of human hepatitis C virus (HCV): gene organization, sequence diversity, and variation". Microb. Comp. Genomics 5 (3): 129–51. 19. Garcia JE, Puentes A, Súarez J, et al. (February 2002). "Hepatitis C virus (HCV) E1 and E2 protein regions that specifically bind to HepG2 cells". J. Hepatol. 36 (2): 254–62.

Similar Essays

Hcv: The Hepatitis C Virus Essay

926 words - 4 pages Hepatitis is inflammation of the liver. There are currently five known viruses that cause can hepatitis (Microbiology, 10e). The hepatitis C virus (HCV) is transmitted through contact with the blood of an infected person; however, it is now more commonly spread among IV drug users that share needles. Healthcare workers are also at risk for contracting HCV, but with standard precautions, the risk is low. “Prior to 1992, some people acquired the

Hepatitis C Essay

1004 words - 4 pages ). Liver failure from chronic hepatitis C is one of the most common causes of liver transplants in the United States. Hepatitis C is an inflammation of the liver’s cells and tissues caused by the hepatitis C virus (HCV). Hepatitis C virus is blood-borne, which means it is spread through blood and blood products (Grady). After the discovery of hepatitis A virus in 1973 and hepatitis B in 1963, any cases of acute or chronic hepatitis or cirrhosis

Liver Disease Hepatitis C Essay

766 words - 3 pages Liver DiseaseI chose liver disease as my subject, specifically Hepatitis C ("HCV"), because my father was diagnosed with HCV in 1999. He went on Interferon every other day for six months in 2000 and it didn't work. He went on it again every day for 18 months starting in 2001 and it still did not work. He had carried this disease for 30+ years without knowing he had it. He found out by going to a Podiatrist for a heal spur. The Doctor wanted to

Hepatitis C Essay 592 Words

592 words - 2 pages injected drugs, being exposed to human blood, received a blood transfusion or blood products before 1992 or overseas (Turkington, 13).The hepatitis C virus affects the liver, as well as other cells such as white blood cells and the lymphatic system. This is thought to make the disease more complicated to treat. People with chronic HCV (hepatitis c virus) may experience a broad array of symptoms. Symptoms may include flu like illness with chills