This website uses cookies to ensure you have the best experience. Learn more

Hepatitis C: The Potential Therapy For Hepatitis C

1724 words - 7 pages

Introduction
Hepatitis C is a chronic liver disease that is caused by an infection from hepatitis C virus (HCV). The hepatitis C virus is an RNA virus that belongs to the Hepacivirus genus of the Flaviviridae family (Lauer and Walker, 2001). Nearly 170 million people are chronically infected by this virus, which represents approximately 3% of the world population (Mohd Hanafiah et al., 2013). Chronic hepatitis C can lead to other serious liver diseases such as hepatocellular carcinoma and liver cirrhosis (Zazrin et al., 2013). For this reason, hepatitis C is regarded as one of the major global health problems. Hepatitis C is an asymptomatic disease in which shows no signs or symptoms and the infected patients usually are unaware about the disease. To date, there is no rapid and effective vaccination or treatment with zero side effects to cure hepatitis C.
There are a few approved treatments available to reduce the effect of hepatitis C on liver; however, the efficiencies are not guaranteed 100%. Therefore, I will further discuss the efficiency of the approved treatments for hepatitis C in this bibliography and my final literature review. I will also emphasize on the different type of treatments available to lower down the risks of liver damage caused by hepatitis C.
This article provides the information about a linear peptidomimetic HCV serine protease inhibitor called as telaprevir in phase III trials. During phase II trials conducted beforehand, the combination of telaprevir with peginterferon-ribavirin was more efficient when compared to peginterferon-ribavirin alone, which suggested that the duration of telaprevir with peginterferon-ribavirin treatment can be shortened in most patients. 1088 untreated HCV genotype 1 patients were involved in this randomized, double-blind, placebo-controlled trial, which was conducted internationally. These patients were divided into three treatment groups: combination of telaprevir with peginterferon-ribavirin for 12 weeks (T12PR group), combination of telaprevir with peginterferon-ribavirin for 8 weeks and placebo with peginterferon-ribavirin for 4 weeks (T8PR group), and combination of placebo with peginterferon-ribavirin for 12 weeks (PR group). After 24 weeks of treatment, a significantly higher number of patients from T12PR (75%) or T8PR (69%) groups had achieved sustained virological response (P<0.001) as compared to patients from PR group (44%). 58% of the total telaprevir-treated patients were able to receive the full 24 weeks of treatment. Side effects such as anaemia, rash and gastrointestinal disorders occurred at higher rates in patients receiving telaprevir-containing regimens, as compared with peginterferon-ribavirin alone. Therefore, 24 weeks of therapy with telaprevir and peginterferon-ribavirin resulted in a significant increase in sustained virologic response (SVR) rates of untreated HCV genotype 1 patients, in comparison with peginterferon-ribavirin treatment alone.
This article is useful...

Find Another Essay On Hepatitis C: The Potential Therapy for Hepatitis C

Hepatitis C Essay

922 words - 4 pages % for genotype 1, and 66% for genotype 2 and 3.CONCLUSION: I. Hepatitis C is very a deadly disease that must not be underestimated.A. It's good to be informed on what Hepatitis C is. B. Know what the symptoms are. C. Know that there are treatment available.II. You must keep in mind that Hepatitis C kills 8,000-10,000 Americans a year and that there are over 4 million Americans infected with HCV; It is better to be informed

Hepatitis C Essay

592 words - 2 pages antibodies to the hepatitis c virus in your blood, it does not look for the virus itself. This test is best for early detection because early test of the liver can show it to be functioning normal even though you have the HCV infection. If the doctor does find the hepatitis C virus, he/ she will then next look for the occurrence of the virus in the blood by finding nucleic acids related to the virus. These test are more reliable than the

HCV: The Hepatitis C Virus

926 words - 4 pages done today. People that have been infected with Hepatitis C are recommended to get vaccinated against Hepatitis A and B, to safeguard the liver against further damage. Prevention of Hepatitis C is only limited to minimizing exposure and risk. It is recommended that personal items such as razors, toothbrushes, and nail clippers not be shared, because of their potential for contact with blood. Unfortunately, IV drug users continue to be at highest

Treating Chronic Hepatitis C

808 words - 3 pages pathway to ketone-reduced metabolites that are inactive against HCV, it also undergoes oxidative metabolism mediated by CYP3A4/5, to a lesser extent. Victrelis is a direct acting antiviral drug against the hepatitis C virus. Boceprevir is an inhibitor of the HCV NS3/4A protease that is necessary for the proteolytic cleavage of the HCV encoded polyprotein into mature forms of the NS4A, NS4B, NS5A and NS5B proteins. Boceprevir binds covalently, but

Hepatitis C (HCV)

3005 words - 12 pages Hepatitis C (HCV), a single stranded RNA virus from the family Flaviviridae, now accounts for more disease and death that does human immunodeficiency virus HIV/AIDS. Approximately 3 million individuals within the United States are currently suffering from what was once and unknown and untreatable virus. Non-A and non-B hepatitis are two forms of the virus that were prevalent back in the 1970’s. It was commonly acquired via blood transfusion as

Liver Disease - Hepatitis C

766 words - 3 pages Liver DiseaseI chose liver disease as my subject, specifically Hepatitis C ("HCV"), because my father was diagnosed with HCV in 1999. He went on Interferon every other day for six months in 2000 and it didn't work. He went on it again every day for 18 months starting in 2001 and it still did not work. He had carried this disease for 30+ years without knowing he had it. He found out by going to a Podiatrist for a heal spur. The Doctor wanted to

Malaria Disease and Hepatitis C

633 words - 3 pages lymphatic system, the immune system and the brain. Structure Once infected with hepatitis C, the immune system begins to fight the virus. In some people, the immune system is able to fight the virus and clear the virus for good. In most people infected with hepatitis C, the virus stays in the body for a long time and this is known as chronic hepatitis C. The structure of the hepatitis C virus is like that of most complex viruses a core of

Blood-Borne and Infectious Diseases: Hepatitis C

3169 words - 13 pages GP with any symptoms of the disease, it is likely that this routine antenatal screening for hepatitis C was performed to determine the likelihood of an unrecognised infection and consequent transmission of a potential infection to the fetus.Pre Testing:Before the testing takes place, it is the responsibility of Mariah's treating doctor to provide her with an overview of the hepatitis C virus, modes of transmission, prevention and

Common Conditions Associated with Hepatitis C

756 words - 4 pages Common Conditions Associated with Hepatitis C Hepatitis C is a contagious liver disease caused by infection of hepatitis C virus. It is also the most common form of viral hepatitis. Hepatitis C virus can be transmitted through needles that are contaminated and blood transfusions, wherein severity could range from mild illness that could last for several weeks to serious, lifelong condition. According to the World Health Organization or WHO

Everything You Need to Know About Hepatitis C

687 words - 3 pages Hepatitis C is an inflammation of the liver. Type C hepatitis can cause serious illness and may increase your risk of liver cancer. There are two main types of hepatitis-acute and chronic. Acute hepatitis comes on quickly and also goes away sooner. Hepatitis is considered chronic if it lasts for six months or longer. It usually comes on slower and the symptoms are more mild. Type C is the most common cause of Chronic Hepatitis. It can also lead

Coinfection of HIV, Hepatitis C virus, and Hepatitis B virus among Injection Drug users in Isfahan Drop in Centers

773 words - 4 pages programsreduction programs in mentioned centers but for achieving more favourable results harm reduction programmsprograms should be still expanded. Key words: HIV, hepatitis C virus, hepatitis B virus, coinfection, Drop in Center Introduction: Hepatitis B virus, hepatitis C virus (HCV) and Human immunodeficiency virus (HIV) are the three prevalent viral and blood bore infections worldwide (1).They considered as an important public health concerns due to

Similar Essays

Hepatitis C Essay

1831 words - 7 pages ) and as many as 300,000 Canadians are infected with the Hepatitis C virus.The incubation period for Hepatitis C averages six to seven weeks.It is frequently misdiagnosed as about 70-80% of people show no signs or symptoms of infection until the patients are in the chronic stages of the illness.Jaundice (yellowing of the skin and eyes) can occur in 20-30% of those infected. Other general symptoms such as uneasiness, loss of appetite, pain in the

Hepatitis C Essay

1004 words - 4 pages of HCV through sexual intercourse outside menses and between males, but there is current debate as to whether this is actually possible without the presence of a skin or tissue tear or some other disease that provide an opening in the skin of both the infected person and potential recipient. Most people are surprised to learn they have hepatitis C. Many people believe, they were never at risk for acquiring the virus. They, therefore, cannot

Hepatitis C Essay

2406 words - 10 pages treatment. Your doctor will prescribe which drug he feels is best for you, but after you start your drug therapy it is best to get on with your life. If you have hepatitis C, do not let it get you down, and live while you still are living, but you should still follow some guidelines. The number one priority is to eat a healthy diet. Plenty of fresh fruits, vegetables, grain, and fish are good for your body (Turkington 107). Try to avoid eating

Hepatitis C Essay 1828 Words

1828 words - 8 pages receiving any diseases while serving in Vietnam. Some of these vaccines where: hepatitis B, influenza, MMR/MR, meningococcal, tetanus diphtheria, and yellow fever. Military Personal used Jet Injectors to disburse the medications. This was ideal for mass immunizations, but unbeknownst to many back then, this was also a perfect way of transmitting blood-borne pathogens like hepatitis C (Dominitz et al., 2005). The injectors were needleless and