Hepatoprotective And Anti Hyperlipidemic Effect Of Houttuynia Cordata

611 words - 3 pages

Houttuynia cordata Thunb (Saururaceae) is a traditional medicinal herb used to treat several disease symptoms including allergic inflammation and anaphylaxis. The present study was focused on the hepatoprotective and anti-hyperlipidemic effects of H. cordata ethanol extract (HCE) in experimental mice. Further the antioxidant potential of HCE extract was also evaluated to substantiate its hepatoprotective and anti-hyperlipidemic effects. Carbon tetrachloride (CCl4)-induced hepatic damage in mice was used to measure the biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (ASP), alkaline phosphatase (ALP), cholesterol levels, triglycerides (TG), high density lipoproteins (HDL) and low density (LD)/very low density lipoproteins (VLDL) in serum samples using respective diagnostic kits. CCl4-induced morphological changes in hepatocyte architecture were studied by haematoxylin and eosin (H&E) staining. In vitro alkyl and hydroxyl free radical scavenging assays were performed to evaluate the antioxidant effect of HCE. Administration of HCE extract significantly reduced the elevated serum levels of ALT, AST, and ALP and regulated the altered levels of total serum cholesterol, TG, HDL and LD/VLDL levels in CCl4-induced hepatotoxicity in mice. The morphological changes in hepatocyte architecture were also reversed by HCE pre-treatment. Further, HCE showed significant antioxidant actions by scavenging the alkyl and hydroxyl free radicals. The concentration of HCE extract necessary for 50% (IC50) scavenging of alkyl and hydroxyl radicals was 15.5 and 410 µg/ml, respectively. HCE extract exhibited hepatoprotective and anti-hyperlipidemic activities in CCl4-induced hepatotoxicity in mice. The strong antioxidant activities possessed by HCE extract might be responsible for such actions.
Key-words: Heartleaf, antioxidant, hydroxyl radicals, hepatotoxicity, hyperlipidemia, carbon tetrachloride

Liver is an important organ which plays a central role in metabolic homeostasis [1]. Hepatitis, environmental pollutants, bacterial and viral infections, alcohol abuse are...

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