This website uses cookies to ensure you have the best experience. Learn more

Human Health: Understanding The Activity Of Signal Pathway

952 words - 4 pages

The research, in this article, is significant to human health because the understanding of the activity of a signal pathway can or cannot give you a grasp on how it can affect other processes in the body. If the effects are known and understood, then we can know how to treat and/or modify the processes and give a discovery in the field of science.
Specifically, in this article, understanding the structure of chromatin is vital to understanding how it affects replication, transcription, and repair. If DNA is not available for enzymes to carry out these processes, then genomic activity will not be as effective. Modifying histones is key to understanding the regulation of chromatin and its changes, and how it influences gene expression. Histone modification caused by an active NFκB signaling since it acts like a regulator for this modification can alter the tumor growth and furthermore give a resistance to chemotherapy. During the cisplatin-based treatment, an active NFκB signaling averts histone acetylation, which removes the positive charge from the histones making the condensed chromatin into a more relaxed structure (Ropero & Esteller, 2007). Therefore, there is histone deacetylation, which makes the chromatin in a more condensed and less relaxed structure, which will not allow transcription to take place or other processes that are needed for enzymes to carry them out.
Overall, understanding the structure of histones and how an active NFκB signaling will permit or prevent histone acetylation and deacetylation can affect tumor growth and can or cannot promote head and neck cell squamous carcinoma chemoresistance.
Results:
In this article, since it was found that treating head and neck squamous cell carcinoma with cisplatin-based chemotherapy demonstrated visible changes in the nucleus, the tumor cells were stained with Hoechest 33342 and immunofluorescence to distinguish the phenotype and were analyzed. (Almeida et al., 2014) It was seen that cells that were sensitive to cisplatin-based chemotherapy and normal cells had a massive increase in their nuclear size whereas cells that were resistant to the chemotherapy either had a decrease in their size or stayed in their original size (Almeida et al., 2014). Based on this, it was found that the reaction between the cells and cisplatin-based chemotherapy was caused by changes in the chromatin structure whether it was less condensed in a more relaxed structure or more condensed in a less relaxed structure.
It was also found that since chemoresistant cells have a smaller nucleus and less histone acetylation, creating histone acetylation and adding cisplatin in chemoresistant cells and chemosenstitive cells established that deacetylation and acetylation plays a part in the process. Next, it was determined if NFκB signaling plays a part in the condensation of chromatin whether it was active in chemoresistant cells and inoperative in chemosensitive cells. When NFκB was active in chemoresistant...

Find Another Essay On Human Health: Understanding the Activity of Signal Pathway

Following the pathway of female entrepreneurs

8280 words - 33 pages countries. Nelton (1998) regarded this growth of female entrepreneurship since the 1970s (from 5 per cent to 38 per cent in 30 years, Hisrich et al., 1997) as one of the most significant, yet quietest, revolutions of our time.In addition, it is evident that the entrepreneurial activity of these female entrepreneurs is making a distinct difference in their communities and economies, in both the developed and developing countries. Yet despite the

The Impact of Human Activity on The Environment

1007 words - 4 pages Oxford, are landlocked, and thus had to develop a reliance upon the Thames River. As the British Empire expanded across the globe, the level of activity and traffic on the Thames also increased. An unfortunate byproduct, then, was the subsequent pollution left behind by this high level of human activity in the 19th century. This climax of pollution was brought about by local residents, slaughter houses, and factories alike being legally allowed to

The Impact of Tourism and Human Activity on Biodiversity

2385 words - 10 pages manage and monitor to ensure the wildlife or biodiversity are unaffected by the new development and always support wild flora and fauna. IMPACT OF INDUSTRY Introduction Since early times, the world of human has been haunted by the menace of environmental pollution. Termed of “garbage” or “trash” also known as Municipal Solid Waste (MSW) which means an inevitable product causes by human activity. Development of economic and population growth

Understanding of Human Behavior

664 words - 3 pages By the very definition 'Psychology' is concerned with understanding predicting, and controlling 'Human behavior'. That holds true today, but different fields have differing emphases on (and definitions for) 'Understanding', 'predicting', and 'controlling', as well as differing in what they're prepared to include in their Understanding of 'Behavior'. While there are differences between various theoretical approaches and paradigms in psychology

The Foundation of Understanding Human Anatomy During Renaissance Period

953 words - 4 pages Our understanding in anatomy and physiology today will be deadened without the knowledge from the Renaissance period. Let take a short step to look at what is Renaissance? Based historian, Renaissance means rebirth because “it [is] believed that the human spirit [has] to be reawakened as it [is] in the classical (Greco-Roman) times” (). During this time, the new conception of human emerges as individualism which means a man can create his own

Understanding the concept of need in human society

2298 words - 10 pages In his book “Motivation and Personality” Abraham Maslow proposed his psychological theory of Maslow’s hierarchy of needs, which means that he successively extended the Idea to include observations on people’s characteristic curiosity and not just what motivates them. Many psychological theories about stages in human development are similar to Maslow’s theories (Maslow 1970). To describe the general stages of what motivates humans he used the

Discuss the possible options of reducing the impact of human activity on global climate change.

1082 words - 5 pages stay undergoing to the radical terror-attacks in the Middle East. Now, after understanding the link between readiness of military to the climate change, occurs main question: how military can contribute to the reducing of human activity harming climate change? Firstly, armed forces should diminish the amount of CO2 emission in production of weapons. Promoting the use of clean energy will reduce the utilization of harmful chemical substances

The Impact of Human Activity on the Climate is Global Warming

1291 words - 6 pages Global warming is considered as the impacts of human activities on the climate (Houghton, 2005). The temperature increases observed since the middle of last century have resulted from the increases of greenhouse gas emissions (Eckard, 2010). As the issues of health problem and nature disasters draw more and more attention, GHG emissions reduction becomes a key issue in every walk of life, from politics to business. According to the latest data

Outdoor Recreation: Human Activity Damages The Natural Balance of an Area

725 words - 3 pages The wilderness offers many opportunities for recreation (e.g. biking, camping, fishing, hiking, hunting, nature photography, riding horses, skiing, stargazing, and swimming ). Outdoor recreation fulfils an innate desire humans have to reconnect with nature and themselves. However, outdoor recreation contradicts the objective of wilderness protection. The most insignificant of human activity can extensively damage the natural balance of an

Discuss the estimation of the number of transcriptional enhancers in the human genome, and how to study their regulatory activity

2067 words - 8 pages , differentiation, and proliferation. If gene expression is deregulated, the result is often development of a disease. It is not clear how these genes function and how spatial and temporal expression patterns are established at cell and organismal level. Understanding expression patterns calls for understanding of transcriptional regulatory elements as well as other functional elements of the genome. One of the most important functional elements of human

"The Role of the Media in the Public Understanding of Health Issues" Breast cancer & Silicone implants

2020 words - 8 pages writer has also been contacted by Granada television, to appear in a programme to discuss the health risks attributed to silicone gel implants and cancer. To fully appreciate the understanding of the subject, the writer feels it necessary to explain the connection between breast cancer and silicone implants.Silicone breast implants (appendices, p; 1, Internet 12) are often used to enlarge breasts, and used in reconstructive surgery after

Similar Essays

The Activity Of The Living Human Brain

1720 words - 7 pages activity it is important to understand the levels of brain activity that are present during brain activity. Berger placed electrodes onto the scalp pick up the brain activity. Tiny voltages are detected as the neurone fire and the electrical signal is amplified thousands of times. The results of an EEG are displayed on a polygraph. (Kimble, 2002)Berger was able to see that the results of the EEG produced more than a mess of lines from the neurones. In

The Health Benefits Of Regular Physical Activity

1373 words - 6 pages Nowadays, it is impossible to turn on the television or reading newspaper without hearing the health benefits of the physical activity. This indicates that being active is very important for our lives in order to prevent different types of disease. Buddha said to keep the body in good health is a duty; otherwise we shall not be able to keep our mind strong and clear. There is a close relationship between exercise and physical and mental health

The Impact Of Digital Signal Processing

2137 words - 9 pages There are a great number of applications for Digital Signal Processing and in order to better understand why DSP has such a large impact on multiple aspects of society, it helps to better understand the wide variety of applications it can be used for. Here we will briefly look into the following applications of Digital Signal Processing and their uses; speech and audio compression, communications, biomedical signal processing and applications in

The Immense Gap In Health Care By Global Heath Pathway

862 words - 4 pages coursework I have taken is fundamentally providing global awareness of public health issues from a socioeconomic, environmental, and biological perspective to the general public. Courses such as Public Health Science 1: Human Health and Disease and Biology 179: Cancer Biology can illustrate a vital connection with the pathway theme. For example, Public Health Science 1: Human Health and Disease course focuses on the improvement of avoiding