This website uses cookies to ensure you have the best experience. Learn more

Hydrogen Sulfide: New Gaseous Signaling Molecule In The Cardiovascular System

1581 words - 7 pages

Hydrogen sulfide donors in the cardiovascular system
Since the evolution of H2S as an essential gasotransmitter at cellular level, and based on the fact that H2S characteristically similar to NO; researchers aimed to investigate the physiological effects of H2S on cardiovascular system, proposing that H2S donors may become a potential treatment for various cardiovascular abnormalities including atherosclerosis, hypertension, vasoconstriction and cellular apoptosis induced by reactive oxygen species [24-26]. The cellular mechanism by which H2S induce cardiovascular effects is not well illustrated yet. A recent study suggested that H2S can reduce heart rate and blood pressure through KATP ...view middle of the document...

001).
L-type calcium channel inhibition
The release of calcium from the sarcoplasmic reticulum plays an essential role in cardiomyocytes excitability and contraction, and the influx of calcium through L-type calcium channels is a crucial determinant of intracellular calcium amount as well. Thus, L-type calcium channels has been recognized as an effective treatment for various cardiovascular disorders include myocardial ischemia, arrhythmias, hypertension and heart failure.
The first evidence of the influence of H2S donor on L-type calcium channels carried out by Sun and associates on isolated cardiomyocytes of spontaneously hypertensive and rats [21]. Their study found that NaHS (H2S donor) significantly (p< 0.05) reduced the peak of L-type calcium channel current by average of 19.61 % in isolated cardiomyocytes. In addition; NaHS associated with significant (P< 0.05) reduction on the time to 25, 50, and 90% repolarization when compared to control. Based on these results the authors concluded that H2S is a novel inhibitor of L-type calcium channels in cardiomyocytes but required further investigation as a potential treatment for different cardiovascular diseases contributed in calcium homeostasis.
Myocardial infarction
The high mortality rate associated with myocardial infarction reduced significantly with proper treatment and management [27-28]. H2S constitute a new treatment pathway in myocardial infarction through Vasorelaxation, decreasing oxygen consumption and preventing myocardial apoptosis. A group of researchers induced myocardial infarction surgically on 80 rats and divided them into three groups receiving either vehicle, 14 micro mol/kg of NaHS (H2S donor), or 50 mg/kg propargylglycine (Irreversible inhibitor of CSE; the main H2S synthesizing enzyme in cardiomyocytes) daily for 1 week before MI inducement surgery and 2 days pot surgery. After confirming myocardial infarction by electrocardiography, propargylglycine treated group showed the highest infarct size/total area of myocardium while NaHS treated group had the lowest infarction size (62.9 %, 52.9% and 43.4 %, p< 0.05 between al groups). The size of infarction was further translated to mortality rate when NaHS group had the least mortality rate among three groups followed by control and finally propargylglycine showed the highest mortality rate again (27.5%, 35% and 40%, p< 0.05 between all groups).
Heart failure
Epidemiological studies have shown that the possibility of heart failure post myocardial may reach 24% - 40%, which is mainly started in a form cardiomyocytes apoptosis prior functional heart failure [30-32]. Several studied aimed to investigate cardioprotective characteristics of H2S In animal model of heart failure [33,39]. In order to elucidate the cardiomyocytes protective feature of H2S; a group of researchers tested the effects of NaHS and propargylglycine among Male Sprague–Dawley rats induced to heart failure post acute myocardial infarction surgery. Animals...

Find Another Essay On Hydrogen sulfide: new gaseous signaling molecule in the cardiovascular system

Robert D. Furchgott’s Contribution to the Discovery of Nitric Oxide as a Cardiovascular Signaling

1506 words - 6 pages endothelium-derived relaxing factor (EDRF), a signaling molecule that caused vascular smooth muscle to relax1,3. Lastly, in 1986 Ignarro, showing that vascular endothelial cells produced similar responses when stimulated to produce EDRF and when exposed to NO, determined that nitric oxide and EDRF were the same molecule, thereby uniting the work of Murad and Furchgott into a cohesive vasodilatory model1,2. Nitric Oxide and Vascular Relaxation

Overview of The Cardiovascular System Essay

2023 words - 8 pages The cardiovascular system - The cardiovascular system is responsible for transporting nutrients and removing gaseous waste from the body. It consists of the heart, which powers the whole process, the veins, arteries, and capillaries, which deliver oxygen to tissue at the cellular level. The cardiovascular system carries blood that is low in oxygen away from the heart to the lungs via arteries, where oxygen levels are restored through the air

Roles of the Cardiovascular System

914 words - 4 pages roles in the cardiovascular system. First, our blood carries oxygen from our lungs to all of our tissues. While taking oxygen to our tissues, it also picks up carbon dioxide from them and takes it to our lungs to be removed from our body. Second, it delivers nutrients from our digestive tract to all of our body’s tissues. Third, it takes waste to our kidney’s to be removed from our body. Fourth, it takes hormones to their target cell from the

Obesity and the Cardiovascular System

2664 words - 11 pages Obesity and the Cardiovascular System The main function of the cardiovascular/circulatory system is to continuously pump blood around the body. It consists of the heart, arteries, veins and the capillary network of arterioles and venules. The capillary network is vast consisting of 62,000 miles of blood vessels. Any blockages in cardiovascular system can be very dangerous to our health, even fatal. The heart, the

Cardiovascular System: Leukemia Cancer (Cancer of the Blood)

1257 words - 6 pages Leukemia is a type of cancer that affects the white blood cells in the human body. White blood cells are produce in the bone marrow and normally attack, kill, and fight off foreign invader. However, the bone marrow can produce abnormal white blood cells that vary in size and develop immaturely. These cells are known as leukemia cells, which increase in a large mass of number pushing out and destroy the healthy cells. There are several types

How Inorganic Compounds Impact the Functionality of Signaling Pathways in Mammalian Cells

1945 words - 8 pages similar (Urry 109). The three stages that allow a cell to transmit a signal are as follows: reception, transduction, response (Urry 109). Reception is the beginning stage and is the target cell’s observation that a signal, generally reported via a ligand, is outside the cell (Urry 109). Reception also includes detection, which implies that the signaling molecule has bonded to a receptor protein embedded in the cell’s membrane (Urry 109). Transduction

What makes up the cardiovascular system, and describe the components.How the cardiovascular system works and the effect of exercise on the cardiovascualr system

2381 words - 10 pages Cardiovascular SystemCardio means the heart and vascular means the network of capillaries, arteries and veins.The vital role of the cardiovascular system in to maintain homeostasis, this depends on the continuous and controlled movement of blood through the capillaries that fill every tissue and reach every cell in the body.The heart is a hollow pear-shaped muscular organ that is situated between the lungs, and is in the middle of the chest. The

The New Healthcare System

1954 words - 8 pages be handed out to the public, however the plan is already in motion and cannot be stopped, although most have considered the good and the bad, most have found it unappealing. Many people are asking the question: is Obamacare the new health care system our country deserves or is it going to lead Americans into another economic downfall? For year’s government officials have been striving for better-cheaper healthcare and president Obama

Hydrogen Energy is the Next Giant in Alternative Energy

855 words - 3 pages Hydrogen Energy is the Next Giant in Alternative Energy Hydrogen economy is an alternative source of fuel and energy that does not damage the environment. Fossil fuels which is the fuel used by many countries is damaging the earth and has to be switched to a better alternative, such as the hydrogen economy. Although it is not used in many places it can substitute fossil fuels and give recyclable substances back to the society that uses them

The New Zealand Healthcare System

1911 words - 8 pages coverage so it makes logical sense to look at another nation which as tackled the topic of health care access in a similar broad fashion. New Zealand represents one such nation. All residents of New Zealand have universal health care access as well as disability services which are mainly funded through governmental auspices. The New Zealand system provides preventative care, primary health care services, inpatient and outpatient prescription drugs

Silencing of ECHS1 Attenuates the Proliferation of hepatocellular carcinoma in vitro and vivo by inhibiting EGFR signaling

3064 words - 13 pages Hepatocellular carcinoma(HCC) ranks as the fifth most common malignant cancer and the third leading cause of cancer-related death worldwide(1). Despite the remarkable achievements that have been attained in the treatment of hepatocellular carcinoma, the prognosis of HCC patients is generally very poor(2). Although a large number of molecules and signaling pathways involved in the development of HCC have been identified(3-6), the molecular

Similar Essays

Robert D. Furchgott’s Contribution To Physiology And The Discovery Of Nitric Oxide As A Cardiovascular Signaling Molecule

1988 words - 8 pages photorelaxation in rabbit aorta strips2,6. Furchgott and colleagues also investigated varying concentrations of creatinine phosphate, ATP, ADP, and AMP as sources of experimental failure (diminishing contraction over time) in in vitro tissues and found no correlation. Furchgott accepted the position of chairman at the new pharmacology department at State University of New York College of Medicine in 19566. Furchgott and colleagues showed that

The Cardiovascular System Essay

1434 words - 6 pages component of the cardiovascular system is the blood. The blood is made up of red blood cells, white blood cells, plasma and platelets. Red blood cells, also called erythrocytes, transport oxygen and some carbon dioxide through the body in haemoglobin. White blood cells, also called leucocytes, protect the body from invading microorganisms. Plasma is a fluid, which is mostly water, that the cells, nutrients, metabolic wastes and other molecules are

The Cardiovascular System Essay

1286 words - 6 pages One of the most important systems in the body, keeping it alive, is the cardiovascular system. As a part of the circulatory system, the cardiovascular system pumps blood throughout the body through a network of many arteries and veins, providing it with nutrients and oxygen. Also, the cardiovascular fights infections and disease in the body and creates blood cells. Never the less, blood acts as a filtration system for the body and removes waste

Nitric Oxide In The Cardiovascular System: A Review

984 words - 4 pages Introduction The gaseous free radical nitric oxide is an abundant intracellular messenger molecule that plays a central role in maintenance of health, and is heavily involved in signal transduction in various cells of the body [1]. This molecule acts as a mediator in the regulation of cardiac function as well as having an important role in regulating contractility of the heart and maintenance of vascular tone in the cardiovascular system. As one