Hypoglycemic Activity Of Gynura Procumbens (Lour) Merr. In Alloxan Induced Diabetic Mice

1278 words - 6 pages

Background of the Study
Diabetes mellitus is a serious metabolic disorder wherein the person has high blood glucose level either due to inadequate insulin production or the body’s cells do not respond properly to insulin (Nordqvist, 2010). There are three main types of diabetes namely Type I (insulin-dependent), Type II, and gestational diabetes. All these types are characterized by hyperglycemia or high blood glucose level. A person with diabetes may experience many symptoms such as high blood sugar, high glucose content in urine, weight loss, fatigue, nausea, vomiting, infections, blurred vision, and lethargy or coma (NDIC, 2013).
Diabetes is continuing to be a major health problem in the world. The number of people with diabetes is increasing because of population growth, aging, urbanization, and increasing prevalence of obesity and physical inactivity. Globally in, 382 million people have diabetes in 2013 and by 2035, it is projected to rise to 592 million (IDF, 2013). Approximately 90% of diabetes cases worldwide are type II. Diabetes is the main cause of blindness, amputation, and kidney failure and the WHO projects that it will be the 7th leading cause of death in 2030. In 2010, an estimated 3.4 million people died due to the consequences of high blood sugar (WHO, 2013). Diabetes was the ninth leading cause of death from 1999 to 2002 in the Philippines. As of 2005, diabetes affected one in every 25 Filipinos. In the Philippines, there were 3.4 million diabetes cases in 2010, representing a prevalence rate of 7.7 percent and by 2030, the prevalence rate is projected to rise to 8.9 percent or 6.16 million cases (Valisno, 2013).
At present, the management of diabetes is still a global problem and a successful treatment is not yet discovered. Although a lot of diabetes drugs are already available commercially, many people are still seeking for less expensive and safer treatments. The commercially available diabetes medications such as insulin are costly and have different side effects. The World Health Organization recommends the use of traditional and plant based medicine for the management of diabetes mellitus (WHO, 1994). The Department of Health (Philippines) is also promoting the use of herbal medicine as an alternative treatment for diabetes. It advocates the rational use of safe and effective medicinal plants by the public and health care providers (NIH, 2010). Herbal medicine (botanical medicine or phytomedicine) refers to using a plant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. Herbal medicine is an alternative method for treating diabetes due to their perceived effectiveness, safety, affordability, and acceptability with minimal side effects in clinical experience (University of Maryland Medical Center, 2013). Thus it is important to study plants in order to produce natural hypoglycemic agents.
This research aims to find out if Gynura procumbens (Lour.) Merr. (Sabungai) leaf extract is an...


Prion Transmission through Sexual Activity in Mice with Prostatitis

1029 words - 5 pages prion, PrPC, can undergo a conformational change to form the infectious, misfolded prion, PrPSc (Chiesa & Harris, 2009). The cause of this conformational change is from a mutation in the gene, Prnp, that is used to make PrP. PrPSc binds to the normal PrPC and somehow causes it to transform to PrPSc (Genetics Home Reference, 2014). In recent studies, prion transmission has been observed through blood transfusion, urine in mice with nephritis


2332 words - 10 pages glycemic control,due to limited number of patients. Conclusion Masked hypertension incidence is increased diabetic patients especially with high HbA1c levels,even though it is not statistically different and patients of which HbA1c levels>6.5 had higher blood pressure measurements in ABPM. T2DM patients with a potentially high risk of clinical cardiovascular diseases and hypertension-induced damage to target organs should be finically evaluated for MH.


916 words - 4 pages The main finding of this study is that the serum ADMA levels were significantly increased in MHT patients with DM compared to normotensive diabetic subjects. ADMA levels, BMI, and low HDL levels were independent predictors of MHT in patients with DM. ADMA levels positively correlated with ABPM measurements, especially daytime measurements, but were not related to office BP measurements. ADMA levels may play a role in prediction, with a good

The Power of the Pump; a Life Changing Advancement in Diabetic Technology

2581 words - 10 pages “Nearly 26 million children and adults in the United States have diabetes”. That is roughly eight percent of the population. However, there is a statistic that is even scarier. Of the 26 million people in the U.S. who suffer from diabetes, only about 19 million people have diagnosed diabetes (“Fast Facts”). This means that there are about 7 million people living in the U.S. who are diabetic, but do not know it. Unfortunately, there is not much

Marx's Idea of Alienation in Productive Activity

2780 words - 11 pages Marx's Idea of Alienation in Productive Activity (1) Marx explained that alienation is about the loss of human powers in the society and alienation separates human from his natural word, activities and makes man lose control over his labor activity. Marx alienation from productive activity emerged when human are barred by alienation from realizing their potentials and creativities, this was achieved under capitalism

Differential Radio-resistance in Nutrition Induced Morphotypes of Deinococcus radiodurans R1

2224 words - 9 pages detachment, a very little is known about their role in staphylococci. Recently an extracellular serine protease, Esp secreted by a subset of Staphylococcus epidermidis, shown to inhibit biofilm formation and nasal colonization by S. aureus [17]. Lately, it was shown that Esp has proteolytic activity specifically towards biofilm specific proteins which are associated with S. aureus biofilm formation and host-pathogen interaction [18]. In an

Key Roles in Of Mice and Men

784 words - 3 pages Just like in of mice and Men, America currently needs a helping hand. People search for a job day after day, but just never seem to gain stable employment. George and Lennie find that getting a job can be just that difficult where they currently wander. When they arrive at the ranch, they meet people who relate to people who Setting plays a key role in Of Mice and Men, placing the reader in California during the Great Depression. During the

Loneliness in Of Mice and Men

1095 words - 4 pages In today's society, group or even a family anyone who believe they do not belong can feel “lonely.” Loneliness can be one of the most depressing feelings experienced. Of Mice and Men takes place on a ranch in California during the early 1930s. There many negative viewpoints about certain sexes and races had not yet been resolved. Women and African Americans were perceived as lesser individuals when compared to any white male American, despite

Discrimination in Of Mice and Men

1095 words - 5 pages “I believe discrimination still exists in society and we must fight it in every form.” (Andrew, Cuomo) It’s true, discrimination is everywhere, but was it in Of Mice and Men? It was extremely evident, for example, with Lennie, Crooks, Curley’s Wife, and so on. All the minorities were discriminated against, but why? Discrimination is a serious issue in the world today that runs through the veins of every group of people. People are always

Loneliness in Steinbeck’s Of Mice and Men

2099 words - 8 pages In Steinbeck’s Of Mice and Men he discusses Dreams, loneliness, and strength. Steinbeck’s main characters George, who is classified as a mister know it all so to speak and Lennie, a mentally ill man with the mind of a five year old, have a dream of owning land of their own some day. Curley’s wife, a sly indecisive she devil, had a dream of becoming a movie star and came close, but the talent scout who claimed to be her ticket to Hollywood never

Dramatic irony in Of Mice and Men

714 words - 3 pages The major irony in Of Mice and Men is that George kills Lennie because of their friendship. George kills Lennie to spare him from a worse death. George complained about Lennie and his defects, but realizes his importance only after his death. Once Lennie is dead, George loses the weight of responsibility Lennie caused him, but he is also lonely. Also, Lennie and George's dream to own their own farm that is carried out throughout the novel

Similar Essays

Hypoglycemic Activity Of Gynura Procumbens (Lour) Merr. In Alloxan Induced Diabetic Mice

1125 words - 5 pages procumbens. Statement of the Problem What is the hypoglycemic activity of Gynura prcumbens leaf extract in alloxan-induced diabetic male mice? Objective of the Study The present study will be conducted to determine the hypoglycemic effect of Gynura procumbens (Lour.) Merr. in Alloxan-induced diabetic male mice. Significance of the Study Gynura procumbens grows extensively in Southeast Asia, where it is traditionally used for treatment of

Anti Convulsant Activity Of Coleus Amboinicus (Lour.)

738 words - 3 pages -clonic seizures, it has been proposed that the maximal electroshock test predicts anticonvulsant drug effects against partial seizures. In Pentylenetetrazole (PTZ) induced convulsions the leaf, stem and root extracts of Coleus amboinicus increased the threshold of PTZ-induced convulsions in mice and offered protection against convulsion. In this model, the durations of convulsion in root extract was highest (7.07 min) than stem extract (5.21 min

Evolution In Methods Of Diabetic Treatment

2178 words - 9 pages complication within the mice. Overtime the mice grew to be intolerant of the extra insulin they produced and no longer responded to it correctly, showing an example of how diabetes works. From their experiment they noticed that type II diabetes was induced by hyperinsulinemia versus no insulin being produced at all. After completing tests in the preliminary phases researchers hope to figure out treatment options for patients with insulin resistant

Summary Of: Apoptosis In Human Hepatoma Hep G2 Cells Induced By Corn Peptides And Its Anti Tumor Efficacy In H22 Tumor Bearing Mice

1532 words - 7 pages Phytomedicine, 3, 1-18. Festing, Michael FW. "BALB/c". (1998) Inbred Strains of Mice. Jackson Laboratory. Fulda, S., & Debatin, K. (2006). Extrinsic Versus Intrinsic Apoptosis Pathways In Anticancer Chemotherapy. Oncogene, 25(34), 4798-4811. Li, J., Zhang, J., He, H., Ma, Z., Nie, Z., Wang, Z., et al. (2013). Apoptosis in human hepatoma HepG2 cells induced by corn peptides and its anti-tumor efficacy in H22 tumor bearing mice. Food and Chemical Toxicology, 51, 297-305. Tortora, G. J., & Funke, B. R. (2013). Microbiology: an introduction (11th ed.). Boston: Pearson.