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Idkid, Essay

4932 words - 20 pages

Doi: 10.2967/jnumed.114.141705 Published online: August 28, 2014.
2014;55:1567-1572.J Nucl Med.
David M. Wilson and John Kurhanewicz
C MR for Molecular Imaging of Prostate Cancer13Hyperpolarized
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F O C U S O N M O L E C U L A R I M A G I N G
Hyperpolarized 13C MR for Molecular Imaging of Prostate Cancer
David M. Wilson and John Kurhanewicz
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity nuclei. This technique facilitates the study of real-time metabolism in vitro and in vivo using 13C- enriched substrates and has been applied to numerous models of human disease. In particular, several mechanisms underlying prostate cancer have been interrogated using hyperpolarized 13C MR spectroscopy. This review highlights key metabolic shifts seen in prostate cancer, their study by hyperpolarized 13C MR spectroscopy, and the development of new platforms for meta- bolic study.
Key Words: PET/MR imaging; PET/MRI; 13C-magnetic reso- nance; prostate; prostate cancer; hyperpolarized 13C; metabolism
J Nucl Med 2014; 55:1567-1572 DOI: 10.2967/jnumed.114.141705
The recent first-in-man hyperpolarized 13C MR imaging study in prostate cancer patients has confirmed the clin- ical potential of this remarkable technology (1). Hyper- polarization using dynamic nuclear polarization (DNP) is now a robust technique used to dramatically increase the signal-to-noise ratio of nuclei that have a spin of one half. This increased sensitivity has facilitated the study of chem- ical phenomena in solution and the probing of a variety of metabolic pathways in vitro and in vivo (2). The technique is particularly sensitive to the metabolic reprogramming that occurs in malignancy and has been applied to several cell and animal models of prostate cancer. Prostate cancer is now the most commonly diagnosed
cancer in men in the United States, with an estimated 233,000 new cases of the disease in 2014 (3). The landscape of the disease is changing rapidly, motivating new therapeu- tic and...

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