Incidence And Treatments For Diabetes Mellitus

632 words - 3 pages

Diabetes mellitus is a chronic metabolic disorder which is characterized by hyperglycemia, relative insulin insufficiency and insulin resistance. According to Food and Agriculture Organization (FAO) projections, the prevalence of diabetes is likely to increase by 35% by the year 2025 (Boyle et al., 2001) and approximately, 140 million people worldwide suffer from diabetes. The disease becomes a real problem of public health in the developing countries, where its prevalence is increasing steadily. Developing countries like India have today become the diabetic capital of the world with over 20 million diabetics and this number is set to increase to 57 million by 2025 which makes it a country with the highest number of diabetics in the world (King et al., 1998). Experimental and clinical studies indicate the extensive chemical modification of collagen, an important constituent of most of the tissues, in the etiology of diabetic complications (Reiser, 1998; Vlassara et al., 1994). Sugar and primary amino group of protein. The reaction proceeds through a Schiff base adduct, followed by an amadori rearrangement, to yield a stable, ketoamine derivative of proteins (Paul and Bailey, 1996,Reiser, 1998).Oral hypoglycemic drugs and dietary manipulation play a prominent role in the treatment of diabetes (Gray and Flatt 1997). Diabetes Control and Complications Trial (DCCT) showed that, near-normalization of blood glucose by intensive insulin therapy reduced the risk of development of diabetic complications. However, intensive insulin therapy carries a high risk of side effects, especially occurrence of severe hypoglycemia. (Watkins, 2003).
The control of blood glucose in diabetic patients is achieved mainly by the use of oral hypoglycemic/antihyperglycemic agents and insulin. However, all these treatments have limited efficacy and have been reported to be associated with undesirable side effects (Harrower, 1994). In order to overcome the side effects associated with diabetes, interest has been shifted to the use of alternative medicine. Herbal and medicinal plants are...

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