Keratin 8 Protein Essay

2030 words - 8 pages

Margaret ChangFeederAP BiologyPeriod 61 April 2014Blast ActivityThe protein I chose was Keratin 8, transcript variant 1 found in mRNA. Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18. Antibodies to CK8 (e.g. CAM 5.2) can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast. CAM 5.2, an antibody that reacts with an epitope found on both CK8 and CK18, is used in immunohistochemistry to demonstrate certain forms of cancer. In normal tissue, it reacts mainly with secretory epithelia, but not with squamous epithelium, such as that found in the skin, cervix, and esophagus. However, it also reacts with a range of malignant cells, including those derived from secretory epithelia, but also some squamous carcinomata, such as spindle cell carcinoma. It is considered useful in identifying microscopic metastases of breast carcinoma in lymph nodes, and in distinguishing Paget's disease from malignant melanoma. It also reacts with neuroendocrine tumors. Keratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood. The cladogram of this protein is attached to the back of this document. One of the species that share the protein Keratin 8 is the Macaca Fascicularis. The crab-eating macaque (Macaca fascicularis), also known as the long-tailed macaque, is a cercopithecine primate native to Southeast Asia. It is referred to as the cynomolgus monkey in laboratories. It has a long history alongside humans; they have been alternately seen as agricultural pests, sacred animals in some temples, and more recently, the subject of medical experiments. The crab-eating macaque lives in matrilineal social groups with a female dominance hierarchy,Fiot They are opportunistic omnivores and have been documented using tools to obtain food in Thailand and Myanmar. The crab-eating macaque is a known invasive species and a threat to biodiversity in several locations including Hong Kong and western New Guinea. The significant overlap in macaque and human living space has resulted in greater habitat loss, synanthropic living, and inter- and intra-species conflicts over resources. The scientific name of the crab-eating macaque is Macaca fascicularis. Macaca comes from the Portuguese word macaco, which was derived from makaku, a HYPERLINK "http://en.wikipedia.org/wiki/Crab-eating_macaque" \l "cite_note-van_Noordwijk.2C_Maria.2C_Carcel_van_Schaik.2C_1999-10" and male members leave the group when they reach puberty. (West African language) word (kakumeans 'monkey' in Fiot).[14] Fascicularis is Latin for 'a small band or stripe'. Sir Thomas Raffles, who gave the animal its scientific name in 1821, did not specify what he meant by the use of this word. In Indonesia and Malaysia, M....

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