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Melatonin Und Das Sympathische Nervensystem (Text In German) Melatonin And The Autonomic Nervous System: Literature Search To The Relation Between Melatonin And The Autonomic Nervous System.

8456 words - 34 pages

1. Einleitung 12. Das sympathische Nervensystem als Teil des autonomen Nervensystem 32.1. Hauptfunktionen des sympathischen Nervensystems 32.2. Aufbau des sympathischen Nervensystems 42.3. Arbeitsweise und Neurotransmission des sympathischen Nervensystems 52.4. Kontrolle durch Hirnstamm und Hypothalamus 63. Melatonin (N-Acetyl-5-Methoxytryptamin, MEL) 73.1. Was ist Melatonin? - Allgemeine Effekte und Eigenschaften 83.2. Zelluläre Wirkungsweise und Rezeptoren von Melatonin 93.3. Physiologie der Melatoninsekretion und -synthese 114. Einfluss des sympathischen Nervensystems auf die Melatoninsynthese 134.1. Noradrenerge Regulation der Melatoninsynthese 134.1.1. Noradrenerge Rezeptoren in der Zirbeldrüse 144.1.2. Aktivierung von second messenger durch Noradrenalin 154.1.3. Akute Effekte von Noradrenalin auf die Melatoninsynthese 164.1.4. Beteiligung von NA bei der Beendigung der Melatoninsynthese 174.1.5. Langfristige Konsequenzen von noradrenerger Stimulation auf die Zirbeldrüse 175. Effekte von Melatonin auf den Sympathikus 185.1. Melatonin und Plasmakatecholamine 195.2. Melatonin und MSNA/RSNA 205.3. Melatonin und das kardiovaskuläre System 225.3.1. Melatonin und Blutdruck 235.3.2. Melatonin und Herzrate (HR) 255.3.3. Melatonin und Herzratenvariabilität (HRV) 266. Diskussion und Ausblick 267. Literaturverzeichnis 281. Einleitung"Melatonin - Schlüssel zu ewiger Jugend, Gesundheit und Fitness" oder "Melatonin, die Wunderdroge". Durch solche und ähnliche Titel wird das Hormon Melatonin seit nicht geraumer Zeit angepriesen. Die Liste der Leiden, die das Hormon angeblich kurieren kann, ist lang und vielversprechend: Als ewiger Jungbrunnen soll es die Alterung stoppen, freie Radikale fangen, Krebs bekämpfen, Kopfschmerzen lindern, vor Schlaganfall, Verkalkung und Herzinfarkt schützen, , Gedächtnis- wie Libidoverlust, Schnupfen, AIDS, Schizophrenie, prämenstruellen Beschwerden und Alzheimer bewahren und schlank machen - heißt es. Dabei wurde dieses Hormon erst im Jahre 1958 von A.B. Lerner und J.D. Case isoliert. Damit begann ein Siegeszug des "Wundermittels", der seinen Höhepunkt Mitte der 90 Jahre erreichte, als in Amerika 1994 Melatonin als "Nahrungsergänzungsmittel" deklariert wurde - da es aus Tomaten und Bananen gewonnen wird- setzte angesichts der enormen Nachfrage eine Art kollektive "Melatonin-Madness" ein: In Kalifornien beispielsweise wurden 1995 mehr Dollar für Melatonin ausgegeben als für Aspirin.Wissenschaftlich solide Belege für die meisten der angepriesenen Gesundheits-wirkungen fehlen jedoch bis heute. Dass Melatonin antioxidativ wirkt, d.h. aggressive freie Radikale abfangen kann, ist dagegen unbestritten. Ein relativ neues Gebiet ist die...

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