This website uses cookies to ensure you have the best experience. Learn more

Methods For Peripheral Nerve Repair Essay

1044 words - 5 pages

Peripheral nerve injuries often result in grim consequences for afflicted individuals including the loss of touch perception, continuous pain, impaired motor functions, and the loss of responsiveness in entire limb. Peripheral nerve injury occurs when a nerve is compressed, crushed or severed and the communication between the peripheral and central nervous system is ruptured and lost (NEURAL TISSUE ENGINEERING: Strategies for Repair and Regeneration). Current methods for peripheral nerve repair consists of surgically reconnecting the distal and proximal nerve ends, a highly favorable procedure for small nerves; however, large nerves gaps of 10 mm and greater are subjected to specifically sensory auto grafts. This method for large nerve injuries rarely results in near complete or complete recovery of function—impairing the quality of life for the individual. In addition, sensory autografts are faced with dreaded issues that consist of a shortage of donor nerves and the mismatch of donor nerve sizes (Peripheral nerve regeneration: An opinion on channels, scaffolds and anisotropy). Although a definitive engineered alternative to sensory autografts has yet to be successfully established, researchers have focused their efforts on one particular strategy for peripheral nerve repair and regeneration, decellularized nerve grafts. Serving as a nerve guidance channel it enables the synchronized lengthening of the proximal nerve stump and axonal growth into an engineered scaffold (A Novel Internal Fixator Device for Peripheral Nerve Regeneration). As a result, this provides an opportunity to examine the mechanical influences of peripheral nerve regeneration and to further evaluate the effectives of decellularized nerve grafts as a method in repairing large nerve gaps.
Studies of peripheral nerves regeneration use anatomical and histological measures to determine the rate of success. Histology staining techniques allow for the identification of different cellular components of interest. The subject of interest, myelin, allows for faster communication throughout the body. Peripheral nerves are complex structures that consist of the following main components: neuron axons, myelin sheathes generated by support cells known as Schwann cells that aid in neuronal activity, and an extracellular matrix (NEURAL TISSUE ENGINEERING: Strategies for Repair and Regeneration). Though decellularized nerve grafts may proof to increase nerve regeneration, to assess nerve repair one must examine the quality of myelination after the repair is completed. Current nerve staining methods are poor and do not produce adequate histological image results that truly differentiates myelin from other cellular components. Therefore, to produce the clearest and most time efficient staining method to label myelin, frozen sections containing samples of rodent nerve tissue will be and subjected to modified Toluidine Blue and Luxol Fast Blue combination staining methods. The expected results...

Find Another Essay On Methods for Peripheral Nerve Repair

Now you see it, now you don’t

1006 words - 5 pages What types of cells are reasonable for peripheral vision? Light passes through your lens and hits the back of the eye (retina), where you have rods and cones. The cones detect color and rods detect light levels. In humans there are FAR more rods then cones in an eye. Also peripheral vision is just caused because we all have a line of sight that is more than straight ahead. Peripheral vision is a part of vision that sometimes occurs outside the

hahahaha Essay

6850 words - 27 pages Nervous SystemPeripheral nervous systemThe peripheral nervous system is composed of bundles of impulse-carrying nerve cell fibers-12 pairs of cranial nerves and 31 pairs of spinal nerves-that transmit information to and from the central nervous system. This division of the nervous system is called peripheral because the nerves extend to the outlying, or peripheral, parts of the body.2.1 Cranial Nerves (Animation)Let's look first at components of the

lzk jshxlfh ladsj hlsdlhzx

6850 words - 27 pages Nervous SystemPeripheral nervous systemThe peripheral nervous system is composed of bundles of impulse-carrying nerve cell fibers-12 pairs of cranial nerves and 31 pairs of spinal nerves-that transmit information to and from the central nervous system. This division of the nervous system is called peripheral because the nerves extend to the outlying, or peripheral, parts of the body.2.1 Cranial Nerves (Animation)Let's look first at components of the

How the Nervous System Works

729 words - 3 pages nerve impulses throughout the body. It consists of two main parts, the central nervous system, or the CNS, and the peripheral nervous system, or PNS. The central nervous system is made up of the spinal cord and the brain. The job of the CNS is to receive information from various parts of the body, analyze and store the information, and then send out instructions based on the information it has received. The peripheral nervous system is composed

Mechanisms of Neuronal Repair Following Nerve Damage

1564 words - 7 pages cells derived from human embryonic stem cells by an electric field. Feng JF, Liu J, Zhang XZ, Zhang L, Jiang JY, Nolta J, Zhao M. Stem Cells, February 2012, 30(2): 349-55. Stem cell-based strategies for treating pediatric disorders of myelin. Goldman S, Schanz S, Windrem M. Human Molecular Genetics, 2008, 17(1)76-83. Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve


648 words - 3 pages the eye. On this picture doctor will see retina, optic nerve, macula, posterior pole. To have this picture on your file will help to monitor progression of the disease. Second step is visual field examination. Visual field is an eye exam that may detect dysfunction in central and peripheral vision, that can be caused by various medical conditions such as glaucoma, stroke, brain tumor. This procedure is performing and repeating once a year to see

Mesenchymal stem cells

1678 words - 7 pages the peripheral nerves. This demonstrated that hADMSCs can accelerate growth of blood vessels and nerve and thus induce generation of tissues. Moreover, another experiment was done in rats to modulate peripheral nerve repair after injury. Rat model was further used to investigate sensory nerve healing with human mesenchymal stem cells. Also, hADMSCs have also proven heal wounds in vitro. These cells may heal wounds that result from vascular

Common Sports Injury

1069 words - 5 pages are involved in the injury?) – Cubital Tunnel Syndrome is caused by increased pressure on the ulnar nerve. It is the second most common peripheral never entrapment syndrome in the human body. The cubital tunnel is a fixed passageway in the elbow that protects the ulnar nerve. The roof of the cubital tunnel is padded with a soft tissue called fascia. The ulnar nerve runs underneath the medial epicondyle and the olecranon. This gap is called the

Sudden Unexpected Deat in Epilepsy

794 words - 4 pages for its prevention. The objective of this study is investigating the role of serotonin (5-HT) and vagus nerve in SUDEP. Our central hypothesis is that SUDEP results from the invading of seizures to the raphe nuclei that contain 5-HT, which inhibit the activity of vagus nerve that regulates cardiac function or respiration (In seizure patients, there is less 5-HT, so there is less inhibition to vagus nerve which means that vagus nerve is more

Nerve Regeneration in the Peripheral Nervous System (PNS) of mammals

643 words - 3 pages INTRODUCTION Nerve Regeneration in the Peripheral Nervous System (PNS) of mammals PNS neurons in mammals have a capacity to regenerate and re innervate the target. However functional recovery varies, depending on the type and location of injury, age of the neurons and other factors, but the recovery is never complete. An overview of the regenerative response Following an injury, in the distal nerve stump a series of degenerative

The Interaction

1214 words - 5 pages . Expression of C5a by microglia; and, CCL2, small inducible cytokine A2 and leucocyte adhesion molecule-I by endothelial cells attract neutrophils, CD4+ cells, macrophages and monocytes in CNS as a response not only for direct nerve injury but also for widespread systemic or well localized inflammation. Blood borne immune cells infiltrate CNS after injury in selective fashion and undergo proliferation and differentiation. Physical remodeling of

Similar Essays

Nerve Regeneration Essay

1831 words - 7 pages the journal article “ Adipose-Derived Stem Cells Stimulate Regeneration of Peripheral Nerves: BDNF Secreted by These Cells Promotes Nerve Healing and Axon Growth De Novo” focuses on stem cells. Adipose-Derived Stem Cells (ASCs), have shown beneficial effects on peripheral nerve repair. Although it would seem logical to harvest Schwann cells for this purpose, the process is very traumatic, and ASCs are much more readily available due to their

Peripheral Neuropathy Essay

1016 words - 5 pages prescribe to victims. The three types of groups of peripheral neuropathy are systemic, external and infections. A good example of peripheral neuropathy caused by an infection is trigeminal neuralgia. The trigeminal nerve is the major nerve of the head and the face, which causes abnormal attacks that, causes pain on one side of the face. For most victims, this uncomfortable symptom can be identified at early stages. The infection may also cause

Mechanisms Of Neuronal Repair Following Nerve Damage

2125 words - 9 pages ensue. Replacement of re-myelinating glia to the injury site in order to hinder neuronal degeneration is an essential aspect of neuronal repair. Along with re-myelination, jump-starting axonal regeneration could play an essential role in reversing paralysis caused by spinal cord injury (Vogel et al, 2005). Severed nerves can often regenerate, but only under optimal circumstances. Nerve regeneration is often interrupted by glial scarring and

Acquire Peripheral Neuropathy Essay

1270 words - 5 pages nerves are weakened and prone to peripheral neuropathy, they may exert pain as a reflex. Pain is the leading symptom of this condition. The pain may be mild or severe and could worsen during the night. It is often caused by inflammation of the nerves that will soon worsen if not treated for. “Symptoms are related to the type of affected nerve and may been seen over a period of days. Muscle weakness is a common symptom of motor damage” (author