Tuberculosis is caused by a bacterium known as Mycobacterium tuberculosis. Tuberculosis (Mycobacterium tuberculosis) is one of the most common infectious diseases in humans. Currently, this disease is becoming more serious because it is characterized by multi-drug resistant. In the case of multidrug resistant TB, it is very difficult to treat and has a high chance of treatment failure, leading to multidrug resistant bacteria to spread rapidly. In addition, the alternative medicines for multidrug resistant bacteria still haven’t been found with cost- effectively or reasonably. While anti TB drugs are effectively but only focus on a few categories. However, patient who is infected to multidrug ...view middle of the document...
Among them, Isoniazid is known as a compound isonicotinylhydrazine resolution ( INH ) , it was discovered in 1912 but 40 years after they last used it for the treatment of tuberculosis . INH is as the first known drug in the prevention and treatment of tuberculosis . However, if one uses isoniazid alone will not get high results because it vulnerable to TB bacteria resistant to quickly.
There are many causes of drug resistance TB bacteria but there are 3 main reasons:
- Drug or target genes was altered in the resistant strain is therefore drugs does not work anymore in killing bacteria .
- Products gene, but its activity is inhibited by drugs excess bacterial production .
- These changes occur at the molecular level and mechanism of drug penetration into the bacterial cell makes the drug concentration inside the cells reached a minimum concentration capable of killing bacteria .
Today the study of molecular biology have identified one mechanism of resistance to antibiotics related to the corresponding genes . For example : RMP resistance has been identified as related to mutations in the gene rpoB core region near the gene encoding the β - subunit of RNA polymerase subunit . SM resistance may be due to mutations in the rpsL gene . PZA resistance may be associated with pncA gene . Can quinolone resistance -related genes gyrA . INH resistance is believed to be primarily related to gene katG . Here we only focused on drug resistance due to mutations in the katG gene.
TB bacteria has its own characteristics :
TB bacteria of bacteria specially constructed by wax so their resistance is very strong with the external environment when the external environment . Even in a strong acid alcohol and certain other bacteria that kills the TB bacteria but still exists . So we call TB bacteria are resistant to alcohol- resistant bacterium box . In the body of the TB patients , TB bacteria are resistant to some drugs that doctors use to destroy them .
TB bacteria tend increasingly resistant to drugs used in treatment . The phenomenon of drug-resistant TB bacteria make treatment work faced many difficulties . Why drug-resistant TB bacteria ? This is a matter to be really interested in global health sector , there are many theories , but theories given by the mutation than convincing .
The phenomenon of bacterial drug resistance occurs due to a change in a natural way without the effects of anti-TB drugs . TB drugs only selective roles only, ie destroy drug resistant strains also , so drug resistant strains still exist and at the same time as the drug -resistant strains is increasing . The researchers suggest that the mechanism of drug-resistant TB is caused by bacteria in the range of genetic chromosomal mutation produced by bacteria resistant TB
drugs . This phenomenon occurs when the tuberculosis bacteria never once exposed to anti-TB drugs but right from the first contact they were resistant to that...