Oarl Cancer Screening Essay

2042 words - 8 pages

Cancer is the second leading cause of death in the US. Oral cancer has high morbidity and mortality rate if not diagnosed and treated early. The five-year survival rate continues to remain at 50 percent, despite progress in surgery and radiation management.90 Squamous cell carcinoma represents 90% of all malignant tumors.91 Early diagnosis of HNSSC is a challenging process for many clinicians. The asymptomatic nature of the disease is the main limiting factor of early intervention. Primary care physicians and general dentists are the most accessible resource to provide oral health care screening to most Americans. Unfortunately, inconclusive clinical examination of people who suffer from dysphasia or other symptoms related to the head and neck is another limiting factor.92 Screening tests with reliable results are required by health professionals to accurately diagnose HNSSC. The invasive procedure associated with biopsies performed in an attempt to diagnose HNSSC many times makes clinicians and individuals reluctant to consider this option, particularly when early stages of cases still seem harmless.
Clinical evaluations that detect early incidences of cancer provide the opportunity to interfere with and avert cancer progression. The hope is always that unsophisticated, noninvasive, low-priced techniques can be used in the process. The criteria of such screening assays may be found in body secretions, such as saliva, urine, and blood serum.
Searching for a biomarker for early diagnosis of HNSSC remains a challenge. Biomarkers are important molecular hallmarks of the phenotype of a cell that assist in early cancer detection and risk assessment.93 Tumor antigens have been identified for certain specific types of cancer; these antigens play an important role in detecting and diagnosing tumors. Overexpressed antigens may break the immune tolerance threshold. Among 31 sera of lung cancer, two overexpressed proteins were found, namely survivin and livin. Anti-survivin antibodies were detected in 58.1% of 31 sera and anti-livin antibodies in 51.3%.94 Evidence for the presence of an over-immune reaction to overexpressed tumor antigens can be applied to HNSSC. p63 is a homologue of p53 that ∆Np63α is one of the common proteins that appears in the basal layer of the epithelia and functions to preserve originator cell populations in stratified epithelia. 88% of HNSSC subjects have demonstrated overexpressed ∆Np63α.95 Different types of immune assays can be used to detect antibodies.
Indirect ELISA has been widely used in much clinical research. The protocol has neither standardized methods nor specific equipment and is thus a flexible method that allows examiners to develop their own appropriate protocol. The simplicity of the method and its safety make it a desirable first choice. It has been used as a first method in HIV screening the positive cases are then reexamined by blot immune assay for verification. The advantages of the technique make it...

Find Another Essay On Oarl Cancer Screening

charant Creon as the Main Character of Antigone

1231 words - 5 pages Creon as the Main Character of Antigone   Throughout the Greek play Antigone by Sophocles, there exists a dispute as to who should receive the designation of main character. Antigone, the daughter of the cursed King Oedipus, as well as Creon, stately king of Thebes, both appear as the key figures in this historic play. I believe that Creon, king of Thebes, should be considered the main character in this work of Greek theater. Three

Free Macbeth Essays: Sleep and Sleeplessness

525 words - 2 pages The Sleep and Sleeplessness Motif in Macbeth We have consciences that function to tell us the difference between right and wrong. If we have clear consciences, we usually possess the ability to sleep. But when our consciences are full of guilt, we experience a state of sleeplessness. In Macbeth, Shakespeare uses the sleep and sleeplessness motif to represent Macbeth's and Lady Macbeth's consciences and the effect Macbeth's conscience has on

Life Outside of Life in Hawthorne’s Wakefield

898 words - 4 pages Life Outside of Life in Hawthorne’s Wakefield   Efficacy lies at the heart of human desires for immortality. Characters throughout literature and art are depicted as wanting to step aside and see what their world would be like without their individual contributions. The literary classic A Christmas Carol and the more recent, but ageless, film It’s Wonderful Life both use outside influences (three ghosts and Clarence the Angel

Essay on Identity in Song of Solomon

2172 words - 9 pages Searching for Identity in Song of Solomon         Abstract: Whether Africans really fly or just escape a monumental burden, perhaps only through death, is a decision Toni Morrison has apparently left to her readers. Never the less, no matter what you believe, within Song of Solomon, the suggestion is, that in order to "fly" you must go back to the beginning, back to your roots. You must learn the "art" from the old messages.   O

The Character of Oedipus in Oedipus and The Infernal Machine

904 words - 4 pages The Character of Oedipus in Oedipus and The Infernal Machine    The stories of Oedipus, as told through Seneca's Oedipus and Cocteau's The Infernal Machine, contain both similarites and differences. Both authors portray the character of Oedipus as being obstinate, ignorant, and inquisitive. Yet Seneca and Cocteau differ on their interpretation of the motives that propelled these characteristics of Oedipus. Seneca portrays Oedipus as a

Okonkwo's Tragic Flaws in Chinua Achebe's Things Fall Apart

3121 words - 12 pages        An increasing amount of contemporary literature traces its origins back to the early works of Greece. For ages, humans have fascinated themselves with the impossible notion of perfection. Unrealistic expectations placed on those who were thought to be the noblest or most honorable individuals have repeatedly led to disappointment and frustration, either on the part of those particular individuals or those they influence. Classic

Sophocles' Antigone - Antigone Must Challenge Creon

889 words - 4 pages Antigone Must Challenge Creon in Antigone   In his "Funeral Oration" Pericles, Athens's leader in their war with other city-states, rallies the patriotism of his people by reminding them of the things they value. He encourages a sense of duty to Athens even to the point of self-sacrifice. He glorifies the free and democratic Athenian way of life and extravagantly praises those willing to die for it. In Antigone, Creon, Thebes's leader in

The Role of Women in Homer’s Iliad

796 words - 3 pages The Role of Women in Homer’s Iliad Homer’s Iliad is undoubtedly focused on its male characters: Achilles, primarily, but also Hector and Agamemnon. Nevertheless, it seems that the most crucial characters in the epic are female. Homer uses the characters of Thetis, Andromache, and Helen as a basis for comparison to the male characters. Homer wants his audience to see and understand the folly of his male characters in choosing war over peace

A Comparison of Butler's Life and Kindred

1915 words - 8 pages A Comparison of Butler's Life and Kindred   What lies in the mind of an author as he or she begins the long task of writing a fiction novel? This question can be answered if the author's life is studied and then compared to the work itself. Octavia E. Butler's life and her novel Kindred have remarkable comparisons. This essay will point out important events of Butler's life and how they link to the mentioned novel. Octavia Estelle

Pillars of Metaphorical Ambiguity in The Scarlet Letter

1439 words - 6 pages Pillars of Metaphorical Ambiguity in The Scarlet Letter Among the multiplicity of arcane elements hidden beneath the words in Hawthorne's "The Scarlet Letter", none is so apparent, yet strikingly subtle to the reader's perception and consumption of characterization than the allegorical play on words within the names of the characters.  Both the protagonist and her rival within the plot are blessed with conveniently appropriate, fitting

An Analysis of Robert Ji-Song Ku's Leda

2003 words - 8 pages An Analysis of Robert Ji-Song Ku's Leda       In Robert Ji-Song Ku's short story "Leda," the main character, Sorin, leads a life of imitation. He applies himself to his graduate studies in comparative literature a little too readily: he compares not just text to text; he also compares his life to text, to "works of literature" (Wong 281). If his life does not match that of at least one literary character on several levels of interpretation

Similar Essays

Reality And Illusion In Shakespeare's Hamlet Reality, Appearance And Deception

896 words - 4 pages Reality and Illusion in Hamlet   Shakespeare’s play, Hamlet, begins with the appearance of a ghost, an apparition, possibly a hallucination. Thus, from the beginning, Shakespeare presents the air of uncertainty, of the unnatural, which drives the action of the play and develops in the protagonist as a struggle to clarify what only seems to be absolute and what is actually reality. Hamlet's mind, therefore, becomes the central force of the

Sub Plots In Hamlet Essay

1118 words - 4 pages Sub-plots in Hamlet   There are many things that critics say make Hamlet a "Great Work," one of which is the way that Shakespeare masterfully incorporates so many sub-plots into the story, and ties them all into the main plot of Hamlet’s revenge of his father’s murder. By the end of Act I, not only is the main plot identified, but many other sub-plots are introduced. Among the sub-plots are trust in the Ghost of King Hamlet, Fortinbras, and

Hamlet As Victim And Hero Essay

1301 words - 5 pages Hamlet as Victim and Hero      Hamlet, Prince of Denmark, a Shakespearean tragedy, tells the story of Prince Hamlet, who gained the knowledge of a terrible incident that his kingdom had suffered. Claudius, the king of Denmark and Hamlet's uncle, had killed his own brother, the king, who was also the father of Hamlet, and married his brother's widow. Hamlet suffered these traumas to a severe degree, and his only relief was to defeat his

Essay On Light And Dark In Antigone

1188 words - 5 pages Use of Light and Dark in Antigone   The "Golden Age" of Greece is noted for its many contributions to the creative world, especially in its development of the play. These performances strived to emphasize Greek morals, and were produced principally for this purpose. Antigone, by Sophocles, is typical. The moral focused on in Antigone is the conflict between physis (nature) and nomos (law), with physis ultimately presiding over nomos