This website uses cookies to ensure you have the best experience. Learn more

Obesity And Hepatocellular Carcinoma Essay

973 words - 4 pages

Liver cancer is a common form of cancer that affects approximately 30,650 new individuals each year (1). The most common form of liver cancer is hepatocellular carcinoma (HCC), which is more predominate in men over women. Along with gender, age also is a large role in the probability of getting HCC. Generally, most of the individuals that are diagnosed with liver cancer are 45 and older, with an average age of 63 (1). Another nonmodifiable factors that can lead to HCC is ethnicity. The risk of having liver cancer greatly increases if you are from the Pacific Islands or are an Asian American (2). Some common behavioral risk factors that can increase an individual’s change of getting HCC are ...view middle of the document...

This study followed the main cell marker p21Waf1/Cip1, which is expressed in the liver and previously known to be in liver cancer (6).
In another particular study done conducted from 1996-2008, 1000 individuals were sampled who underwent orthotic liver transplant (OLT) to see if HCC would reoccur (5). Using BMI and dividing individuals into subcategories such as non-obese, overweight and obese, researches were able to analyze how many participants got HCC and their survival rate after surgery. For obese and overweight individuals with BMIs at or over 25 kg/m2, there was a 15% reoccurrence for HCC in each group, while non-obese individuals only showed a 7% reoccurrence (5). Survival rates for individuals that showed non-obese BMIs had an average of 58 years while obese individuals only showed survival of 41 years after surgery (5).
The PNPLA3 variant is another cell marker that is common in liver cancer. A study was done in Sweden to see if there was a correlation with PNPLA3 and obese individuals. Researchers tested 3,473 individuals and divided them into two subcategories of a control group with 1,719 individuals and a surgery group with 1,754 individuals (3). The surgery group underweight weight loss surgeries such as banding, gastric bypass, or gastroplasty to show a decrease in BMI. The results showed that the PNPLA3 variant was correlated with an increase in the HCC seen in the control group (P-value of .001), but not in the surgery group (P-value of .783) (3).
HCC and other types of liver cancer are continuing to increase in the population today due to the increasing amount of overweight individuals. Various studies have been done internationally to show that obesity is a large risk factor for liver cancer. In Denmark, a study...

Find Another Essay On Obesity and Hepatocellular Carcinoma

Obesity and NAFLD Essay

1003 words - 5 pages , the risk of Hepatocellular Carcinoma was reduced by 36% with compared to people who never drink coffee. Other studies showed that fat in liver and a factor to cause a liver tumor was reduced in the subject who drank coffee regularly. Increases in anti-inflammatory interleukins, chemicals from white blood cells to prevent inflammation, was confirmed then as well. These evidence show that coffee can be effective in preventing NAFLD and obesity

obesity and immunity Essay

1303 words - 6 pages . Hyperinsulinemia accompanied with high levels of insulin-like growth factor-1 (IGF-1) predisposes to colorectal cancer and renal cell carcinoma, the most frequent obesity-induced form of kidney neoplasia. Esophageal adenocarcinoma, is another of the most common obesity-associated neoplasms, presenting a twofold risk. Although obesity-induced gastroesophageal reflux disease (GERD) and Barrett esophagus have been suggested as the prime risk factors for

Alcohol Liver Disease

1274 words - 6 pages factor in ALD pathogenesis is genetic background and its complex interrelationship with direct ethanol hepatotoxicity, as well as with and alcohol-induced metabolic and immunological changes. Secondary factors, such as nutritional and hepatotoxic co-morbid conditions, can critically contribute to the development of liver disease. ALD encompasses a spectrum of liver injury ranging from steatosis and fibrosis to cirrhosis and hepatocellular carcinoma

The Use of Melittin As An Anti-cancer Drug

1615 words - 6 pages tumor cells. What two journals in particular have shown was that, MEL could be used to kill hepatocellular carcinoma cells and leukemic cells that are resistant to tumor necrosis factor (TNF) [1] [2] [5]. TNF is responsible for inducing apoptosis in normal, healthy cells. As a part of their resistance mechanism, some tumor cells become unresponsive to TNF avoiding apoptosis. It is believed that since MEL activates PLA2, and low levels at that

Impact of host IL28B rs12979860, rs8099917 in interferon responsiveness and advanced liver disease in chronic genotype 3 hepatitis C patients

1663 words - 7 pages Chronic hepatitis C virus (HCV) infection is a major cause for developing cirrhosis and hepatocellular carcinoma (HCC), with an estimated global prevalence of 3% occurring in about 180 million carriers and more than 350,000 people die every year from hepatitis C-related liver diseases [1, 2]. According to World Health Organization reports, HCV is found worldwide with certain countries having chronic infection rates as high as 5% or above. In

Performance of global quality of scale of EORTC QLQ-C30 for measuring quality of life

2121 words - 9 pages Primary liver cancer is currently the second leading cause of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the main form of primary liver cancer accounting 70-85% of total liver cancer burden. Key etiologies include viral infections from hepatitis B and C, and cirrhosis. Since these two viral infections are predominant in Asia and Africa, more than 80% of cases are encountered in these regions [Jemal et al., 2011]. Despite

Hepatitis B Virus

1220 words - 5 pages -10% in adults. Some are chronically infected carriers. These people have hepatitis in their liver but they are otherwise normal. Liver diseases such as cirrhosis and hepatocellular carcinoma are the major symptoms. Hepatitis B increases a person's chance of developing hepatocellular carcinoma by over 100-fold. The exact mechanism is unknown but this cancer occurs when HBV's genome becomes integrated into the hepatocytes' DNA. This

Seropositivity of hepatitis B and C among thalassemic patients in Sulaimani city

1260 words - 6 pages chronic disease. [2]. It is estimated that about 2 billion people worldwide have been infected with hepatitis B virus (HBV); 360 million are chronically infected, about 600000 die each year due to HBV associated liver cirrhosis or hepatocellular carcinoma [10]. The HBV have ability to make or express to three type of proteins (HBeAg, HBcAg and HBsAg) which act as antigen in human's body. HBcAg and HBeAg are hepatitis B viral protein. It is an

Identification and Characterization of Somatic Mutations Associated with Progression of Acute Myeloid Leukemia Having FLT3ITD

691 words - 3 pages and its effects of knockdown in Embryonic Stem Cells. Dr Daniel Messerschmidt just started as a junior PI and I am the only member in his lab. Apart from experiments, I also manage laboratory supplies and utilities. This has given me an opportunity to work independently with minimal guidance. Short-term projects and supplementary training during summer and winter of 2010,2011 and 2012 in Tumor induction (Induction of Hepatocellular carcinoma in


1053 words - 5 pages were consistent with the development of hepatocellular carcinoma the most common form of liver cancer. [8] Works Cited 1. "Catching a Cancer." Science News. N.p., n.d. Web. 05 Apr. 2014. 2. Koonin, Eugene V., Tatiana G. Senkevich, and Valerian V. Dolja. "Abstract." National Center for Biotechnology Information. U.S. National Library of Medicine, 19 Sept. 2006. Web. 05 Apr. 2014. 3. "Berkeley Scientific Journal." Can A Virus Cause Cancer: A

What Causes Hepatitis A?

702 words - 3 pages (CDC, 2013)  Illness does not usually last for more than 2 months (CDC, 2013) o Hepatitis B  Virus can live outside a body up to 7 days (CDC, 2014)  Has an incubation period of 1 to 6 months (Smeltzer et al, 2010)  An acute infection may lead to chronic infection. Chronic infection may lead to cirrhosis and hepatocellular carcinoma (Smeltzer et al, 2010)  May last from a few weeks to lifelong (CDC, 2014) Signs & Symptoms: • Hepatitis A and

Similar Essays

Silencing Of Echs1 Attenuates The Proliferation Of Hepatocellular Carcinoma In Vitro And Vivo By Inhibiting Egfr Signaling

3064 words - 13 pages Hepatocellular carcinoma(HCC) ranks as the fifth most common malignant cancer and the third leading cause of cancer-related death worldwide(1). Despite the remarkable achievements that have been attained in the treatment of hepatocellular carcinoma, the prognosis of HCC patients is generally very poor(2). Although a large number of molecules and signaling pathways involved in the development of HCC have been identified(3-6), the molecular

Hepatic Cancer Essay

1018 words - 5 pages years old (ACS). The most common risk factors for liver cancer are a result of chronic hepatitis B or C viruses and cirrhosis (ACS). Additional risk factors include heavy alcohol use, obesity, type 2 diabetes, inherited metabolic diseases, ingestion of aflatoxins, exposure to Thorotrast, use of anabolic steroids, drinking water containing arsenic, and tobacco use (ACS). In the United States, hepatocellular carcinoma is the most common form of

Hypoglycemia Report

558 words - 3 pages patient had NIICH associated with HCC . Other cause of hypoglycemia in hepatocellular carcinoma is adrenal insufficiency from bilateral adrenal metastasis. Consider with corticotropin stimulation test and CT scan of upper abdomen, there were no evidences of adrenal insufficiency or adrenal metastasis. NICTH associated with HCC is infrequently found in clinical practice. There were a number of case reports to control hypoglycemia in NICTH

Molecular Basis Of Cancer Essay

2061 words - 8 pages older and enclosed. Liver cell carcinoma, the most common primary form may be light brown or yellow green. In metastatic carcinoma, the nodules are often smaller and more evenly distributed amongst the liver as well as being nearer the surface. Their margins are not smooth but serrated, umbilication is seen and intravenous growths are not.(Cancer 1954;3;462-501) Hepatocellular Carcinoma Currently there is no cure for Hepatocellular Carcinoma (HCC