Role Of Metabolites In Diagnosing Chronic And Infectious Diseases And The Efficacy Of Therapeutic Interventions

684 words - 3 pages

These scenarios share the critical need to develop noninvasive, low cost techniques that can help make critical decisions that impact everything from health, quality of life, costs, and public health policy. There has been recent interest in understanding the role that metabolites may play in diagnosing chronic and infectious diseases and the efficacy of therapeutic interventions. Since the metabolites represent the current state of the biochemical processes in the body, they are sometimes more relevant than the genomic and proteomic data in understanding the present status of the disease and intervening appropriately. For example, exhaled breath analysis is approved as a test for heart transplant rejection for which right ventricular endomyocardial biopsy was the “gold standard”. Through this noninvasive test, complications such as hematoma, infection, arrhythmia, ventricular perforation and fistulas that resulted from the invasive biopsies can now be avoided. Whereas small molecule metabolites in exhaled breath have been identified as important markers in diagnosing peptic ulcer disease due to H. pylori 1 and monitoring airway inflammation in asthma 2, 3, advanced sensors and devices are needed to progress the field to more complex situations like the ones mentioned above. Noninvasive tests such as exhaled breath analysis is attractive for diagnosing children4, 5 and has a tremendous public policy component, especially in resource poor situations. I will dedicate my research program to develop sensors and devices that will measure and characterize metabolites of respiratory & metabolic diseases with special emphasis on translating research into affordable solutions for point-of-care.

My strong track record of publishing and training students in this area has positioned me well to tackle this challenging line of research. I believe my unique interdisciplinary training in engineering, microfabrication, analytical chemistry, and clinical & translational research positions me strongly to undertake this challenge; thus, this work would offer unlimited ground for collaboration with scientists and engineers in academia, industry, and government. My clinical and translational training provides a knowledge base, intuition, and vocabulary, which strengthens my access to medically relevant...

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