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Pharmocology Drug Lanoxin Brand / Digoxin Generic

822 words - 4 pages

Digonin is synthesized by the hypothalamus in the human body. Outside the body digoxin is extracted from a leaf off the digitalis lanata plant. Digoxin is a white crystal that melts at 230o with no odor; it is not insoluble in water. Digoxin is available in tablets, oral solution and IV. Digoxin comes from cardiac glycosides class of medication. Digoxin is a generic name for Lanoxin. Other brand names for digoxin are cardoxin, digitek, lanoxicaps, and lanoxin. Digoxin contains active ingredients. Digoxin also contains other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. These other ingredients are added to improve the medicine’s ...view middle of the document...

However, tablets absorption rate is slower with food. Digoxin tablets have an absorption rate of 60% to 80%. Digoxin crosses the placenta and the blood-brain barrier, with 25% protein bound. The tissue-distribution of digoxin is 6 to 8 hr. Digoxin has a large volume of distribution due to the concentration in the tissues around 500L. Metabolites are formed by hydrolysis, oxidation, and conjugation; with 13% to 16% being metabolized. The quantity of digoxin eliminated at any time is proportional to the total body content (first-order kinetics). After IV administration, 50% to 70% of the dose is excreted unchanged into the urine.
Doctors usually prescribe digoxin in high doses for the first week of uses, oral tablets 150 mcg per day. The dose is the reduced depending on the patient’s response to the treatment and the condition being treated, usually oral tablets 125 mcg per day. The pediatric dose for children over the age of 12 yrs, oral tablets 50 mcg/ml per day. The pharmacy label on the medication bottle will inform the patient as to how much and when to take the digoxin. Digoxin may affect the patient’s ability to drive or use machinery. Also digoxin has many drugs that can possible cause a drug interaction, for a complete list of these interactions see: http://www.drugs.com/ppa/digoxin.html. Digoxin can also interact with some vitamins, such as calcium, vitamin B1, and St. John’s Wort.
Every patient’s reaction to medication is a little different. A prediction of which side-effect the...

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