This website uses cookies to ensure you have the best experience. Learn more

Protein Crystallography In The Pharmaceutical Chemistry Field

1007 words - 5 pages

Protein crystallography has become a mainstream analytical method in assisting the pharmaceutical chemistry field. Specific work on proteases which are instrumental in lead compound discovery have blossomed over the passed two decades as the need for Co-crystallization of target proteins with small molecules is seeing a drastic increase now that their uses in drug design have become fully apparent. Work on phosphorous cleaving and donating enzymes (Kinases and phosphatases) has also become an area of current interest as potential cancer therapy by affecting the energy yield in a cancer cell through interruption of ATP generation. “The use of protein crystallography is highly influential in structure-guided drug design as researchers can help determine the absolute stereochemistry of a compound and alter it if necessary to favour the necessary binding conformation”3.

Co-crystals:

Pharmaceutical Relevance:
Co-crystals have come up in pharmaceutical chemistry as an important and controversial topic. Although there is disagreement on the definition of what is classified as a co-crystal, their importance in pharmaceutical chemistry and X-ray crystallography is noted. Co-crystals are believed to be a crystalline structure of at least two components composed of atoms, molecules or ions. These components form a single unique crystalline structure and have proven to be quite beneficial in vitro as a medicinal delivery system.
Pharmaceutical Advancement:
Several advances on the design, growth and characterization of co-crystals have increased exponentially over the past several decades. It has only been in the past several years however, that reference to pharmaceutical chemistry has begun to flourish as the discovery that co-crystals actually alter their physicochemical properties without out any effect on bioactivity via structural compromise. Although discovered over 100 years ago, co-crystal chemistry is a relatively newly researched and developed field in the broader spectrum of pharmaceutical chemistry. The use X-ray crystallography is a necessary tool when dealing with co-crystals, as it is essential to successfully isolate and identify these products instead of a concurrent product composed of perhaps a mixed ionic or salt complex.
With regards to absolute structure determination and co-crystal chemistry, Alshahateet et. al4 researched the plausibility of creating an optically pure form of the non-steroidal anti-inflammatory drug (NSAID) Ibuprofen in a co-crystal form for the exact reasons aforementioned. The co-crystal structure does not affect bioactivity but at the same time can alter physicochemical properties in vitro, a property very much desired in the field of pharmaceutical chemistry.
The S-enantiomer of ibuprofen is the API (active pharmaceutical ingredient) “which was examined with a co-crystal composed of 2-aminopyrimidine and its ability for the two to form a co-crystal was characterized by a single X-ray crystallography. It...

Find Another Essay On Protein Crystallography in the Pharmaceutical Chemistry Field

Pharmaceutical industry in the United Kingdom

1016 words - 5 pages INTRODUCTION Pharmaceutical industry in the United Kingdom The pharmaceutical industry in the United Kingdom directly employs around 72,000 people and in 2010 contributed £8.4 billion to the UK's GDP and invested a total of £3.9 billion in research and development. In 2007 exports of pharmaceutical products from the UK totalled £14.6 billion, creating a trade surplus in pharmaceutical products of £4.3 billion. The UK is home to GlaxoSmithKline

Corruption of the Pharmaceutical Industry in America

2914 words - 12 pages unselfish and focused on the patients' needs as people would like to think. Pharmaceutical companies are particularly ruthless, many of them spending millions of dollars per year to convince doctors to prescribe their drugs and to convince consumers that their specific brand of drug is needed in order to cure their ailments. For instance, they may present symptoms that are perfectly harmless, and lead potential citizens to believe that, because

Technlogy in the Medical Field

1347 words - 6 pages smallest technological advance can be helpful. Now with the dangerous jobs in the world and even the dangerous playgrounds, electronic imaging is needed. Electronic imaging, an outstanding technological advancement, helps views bones, organs, and cancerous cells within the body. X-ray or radiograph was the first type of electronic imaging introduced into the medical field. This played an important part in the medical field because it allowed doctors

Computers in the Medical Field

1646 words - 7 pages not be able to do half the things as quickly as we can. Advances in computer design have increased its use for different industries, especially in the medical field. Computers help out hospitals and pharmacies very much. Pharmacists use computers to keep a record of medications and the dosage to give to each patient. Most computers in hospitals are used to keep track of patients and their status. Computers also keep track of equipment placement

Distrust in the Medical Field

1674 words - 7 pages Does racism still exist today? Although many believe it was a problem in the past, it still exists today. Many People are still not aware that it still exists in our workforces, especially in medical field. Although racism in medicine can be very offense, it can sometimes be beneficial and help reveal differences in diseases based on genetic make up. These differences can be taken in the wrong manner and can lead to social problems

Mistakes in the Medical Field

1257 words - 5 pages It’s very difficult to blame someone when mistakes occur in an environment in which we hope learning and improvement will take place. But eventually someone has to take blame for the mistake. Errors can occur anywhere but when it comes to the healthcare field there are more possibilities.It would include acute care, ambulatory care, outpatient clinics, pharmacies, and patient homes. Many people assume that medical errors involve only wrong

Professionalism In The Health Field

688 words - 3 pages manner (demeanor, dress, and hygiene). You recognize and report errors and poor behavior in peers. You have to take responsibility for appropriate share of teamwork. You have to arrive to work on time. You need to be accountable for deadlines, complete assignments and responsibilities on time. To be a person who is deemed professional you have to have a sense of leadership. Leadership in the healthcare field means you have to be willing to teach

The Power and Benefits of Monopolies in the Pharmaceutical Industry

2367 words - 9 pages Due to patents, Pfizer and other companies in the pharmaceutical industry are not always competing in a monopolist’s competition. When a business has a patent they are the only manufacturer who can produce the product until the product expires, so it is clear that the firm can act as a monopoly while in control of the patent. As a monopolistic company, the company has market power, giving it the capability to adjust the market price of a good

Rogers’ Adoption Theory in Automotive Sales the Pharmaceutical Industry

604 words - 3 pages Introduction The Purpose of the study The purpose of this study is to determine whether the use of sales force automation technology in the pharmaceutical industry and the automotive sales industry is based on Rogers’ Adoption Theory. Also, the purpose of this study is to explore whether the use of this technology by innovators is due to perceived usefulness and ease of use, or whether something else is responsible for motivating

Pharmaceutical Companies Stand in the Way of Treatment

3821 words - 15 pages Pharmaceutical Companies Stand in the Way of Treatment Abstract This casebook concentrates on the negative effects that the pharmaceutical industry’s trade and production policies have on third world nations suffering from disease epidemics. My position is that pharmaceutical companies are not concerned with the health benefits of their drugs, but rather with the market that their drugs generate. I illustrate this notion by describing the

IT Project in the Health Industry for ZAP Pharmaceutical

1528 words - 6 pages Introduction: ZAP Pharmaceutical We are managing a large IT project in the healthcare industry for ZAP. Our project consist of the following task: refurbish the existing office building; install the IT infrastructure, and outfit the area for our new telephone answering hub. The project is in the execution phase, with three quarters of the work finish - refurbishing and installation of the infrastructure currently being done in concert with

Similar Essays

Corruption In The Pharmaceutical Industry Essay

1590 words - 6 pages contributors. In 2010, Pfizer Inc, one of the largest research-based pharmaceutical companies, contributed over $900,000, followed by other pharmaceutical and health care industries. Pharmaceutical Rsrch & Mfrs of America, the top lobbying client, spent over $7 million. This just shows how much drug companies will spend to make billions in profit. Its funny how the pharmaceutical industry knows politics as much as they know chemistry; how else are they

Marketing In The Pharmaceutical Industry Essay

2035 words - 8 pages The pharmaceutical industry has become a chief player in the marketing of their products. As its leading companies have such a strong presence in Ireland, and the fact that its marketing policies are forced to vary from country to country, I found it to be a very appropriate topic. It is a highly regulated industry, governed by different global statutory bodies, each incorporating different laws, which marketers must be aware of. I discuss how

Contribution Of Thomas R. Cech To The Field Of Chemistry

769 words - 4 pages process of providing protein in the form of messenger RNA. Some of Thomas Cech on process and future applications are Telomerase structure and function, Chromosome end capping proteins and long non-coding RNA’s regulating transcription. These are on process applications meaning that his researches for these applications will leave positive impacts in the field of Chemistry. Some of Thomas Cech’s publication links are given below: 1. Baumann, P

Interviewing In The Field Essay

657 words - 3 pages The method that was used in this research was qualitative data analysis; field interviewing. Field interviewing is when a researcher ask a lot of questions that are arranged originally from a subject that one can answer openly. When researchers conduct these interviews, they analysis your response to evaluate the similarities and the differences in the responses. This type of research is very semi structured and unlike surveys, there’s