Recruiting The Most Suitable Laboratory Animals For Food Allergy Modeling

2399 words - 10 pages

During the last few years, most of the societies, all over the world, have been facing a progressive increase of adverse reactions to food. Accordingly, as many as 20-30% of the general population, in the gross, report some two adverse reactions to food components, of which, for the most part, allergic disorders are of considerable concerns owing to their epidemic increase in prevalence and morbidity.
Our understanding of these diseases has enabled the search of therapeutic approaches that can either modulate the sensitization process or impact on allergic mediators and hereby, helping manage allergic symptoms/signs.
Currently, numerous strategies for definitive treatment are being studied, but, most of the clinical studies concerning these new therapies are still, performed in animal models and evidently, not all of them do necessarily offer hope for better treatments in mankind subjects.
The objective of this study was to confirm the sensitizing-operation fulfillment in a wistar model of peanut allergy.
21 out of all 50 rats, were subjected to sensitization, three times, one week apart with crude peanut extract(CPE). Each sensitization attempt was done over 2 consecutive days.
Subsequently, rats were challenged, and anaphylactic reaction parameters including variations in plasma histamine levels, vascular permeability, systemic anaphylaxis scores, and total serum Immunoglobulin E levels were measured.
Taking to account the homeostatic similarities between rat and man, previous studies have suggested that the Brown Norway Rats are the most pertinent model for human allergic diseases. Here, based on our findings, we dare report, for the first time, that the wistar model may even be more predictive of human food-allergic responses.

In principle, the adaptive immune response is a critical component of host defense against infection and is essential for normal health. Unfortunately, adaptive immune responses are also sometimes, elicited by antigens not associated with infectious agents, and this can cause serious diseases. One circumstance in which this occurs is when harmful immune reactions known generally as hypersensitivity reactions, are made in response to inherently, harmless environmental antigens called allergens such as foods, pollens, drugs, etc.
Allergic disorders are widespread immune pathologies encompassing skin, food and respiratory allergies. As mentioned before, it is much to be regretted that these immunological ailments involve sensitization, very often, to a normally harmless substance/allergen resulting in the immune system being biased to a predominant of T-helper type 2 subset (Th2) response, so that, re-exposure to the same allergen leads to the release of a whole host of chemical mediators through the effector cells degranulation, among them histamine is considered as the most important mediator that can cause all the pathological features of allergic diseases.2
Currently, numerous strategies for definitive...


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