Local Anesthetics Essay

1059 words - 4 pages

Dentistry is defined as the branch of medicine concerned with the diagnosis, prevention, and treatment of diseases of the oral cavity. A trip to the dental office twice a year is essential as they can efficiently clean our teeth with special tools that we often miss at home, as well as detect tooth decay and periodontal diseases with a trained eye. Having healthy teeth is aesthetically important and essential to the quality of life because it would be difficult to chew and eat without them. However, some individuals cringe at the words dentist and dental office. Many individuals are afraid of a trip to the dentist and experience immense anxiety or stress due to fear of dental pain, and the terrifying noises of the equipment used. In addition, patients are also apprehensive of certain surgeries that require the use of anesthesia. The thought of being ‘put under’ with Lidocaine, not only helps the individual deal with the pain, but have concerns over drooling over one-self, biting one’s lip, and the time they would regain normal sense of feeling in one’s face after leaving the office.The distress regarding the ‘after’ effects of local anesthetics, Lidocaine, have somewhat been championed by a local San Diego company, Novalar. The company’s objective is to bring about novel solutions to dentistry that would revolutionize patient care and experience. In the article brought forth by Xconomy San Diego on November 14, 2008, it describes Novalar’s pitch to comfortably un-numb dental anesthesia with Oraverse (phentolamine mesylate), a drug they discovered. The company’s founder, Dr. Eckard Weber, pondered the issue of cutting the time in half of regaining the sense of feeling with his dentist, as well as the business aspect that no one else in the industry has found a solution to comfortably un-numb the effects of lidocaine. He believes that this venture has a potential to be worth as much as $500 million a year by 2015 due to our nation’s high interest in cosmetic dentistry. In addition, they believe that Oraverse would be a success due to a market research conveying that almost two-thirds of all dental consumers were either very or somewhat uncomfortable with lack of sensation when leaving the dentist’s office. Novalar is simply aiming to tap into the trend of improving the patient experience with the generation of Oraverse. The article states that most dental anesthesia uses a vasoconstrictor, which limits blood flow to the tissues in the mouth around the teeth. In contrast, the Novalar drug is a vasodilator, which allows the blood flow to return to the gums, lips, and cheeks.Dr. Weber and his associates worked on a project to turn the vasodilator from its powder form into a low-dose, stable liquid injectable form. The drug passed a clinical trial in 418 patients, and was approved by the FDA in May 2008. The overall effect of the drug is reducing the time to recover normal sensation in the lower...

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