Research Study On Metformin, A Drug And Its Use For Antipsychotic Treatment

1054 words - 5 pages

Weight-gain, which is associated with antipsychotic treatments, is one of the most important concerns in a psychiatric management. Not only it creates self-esteem issues, but it also leads to serious health problems such as cardiovascular diseases or early death.1 As a matter of fact, there are no effective pharmacological treatments to facilitate weight-loss in psychiatric patients. However, there are some current studies showing Metformin can reduce metabolic rate. As a result, it is considered as a drug of choice in this specific population. Metformin is a biguanide; and its mechanism of action is reducing both hepatic glucose production and intestinal glucose absorption.2 It ...view middle of the document...

3 It involved 72 patients, who were from 18 to 60 years old and diagnosed with first episode schizophrenia.3 The inclusion criteria were participants gained more than 7% of their weight after they had been on antipsychotic drugs within the first year of treatment when they were either discharged from inpatient or first seen in the clinic.3 They also had some stable improvement on therapeutics outcomes and were on only one antipsychotic medication with the dose unchanged by more than 25% over the past 3 months.3 Besides, participants were excluded from the trial if they had cardiovascular, pulmonary or neurological diseases, renal or liver impairment, diabetes, and arthritis.3
The trial was designed with 32 patients in a study group and 34 patients in a placebo group.3 Both groups were given 250 mg of Metformin or placebo twice daily on the first three days, then they continued with 500 mg tablets two times a day thereafter.3 During the trial, antipsychotic drug dosage and regimen remained the same. Participants were not involved in any life-style modification and did not differ in baseline measurements, including demographics, medical history, and physical examination.3
The primary endpoint was changed in body weight. In addition, changes in body mass index, insulin resistance index, fasting glucose, and insulin were the second endpoints. After 12 weeks of treatment, there was a significant difference in the primary outcome, p<0.001.3 Patients in the placebo group gained weight by 3.9%.3 In contrast, patients in the Metformin group lost weight by 5.1%.3 Also, there was a significant difference between the two groups for the second endpoints of body mass index, insulin, and insulin resistance index, p<0.001.3 The mean insulin resistance index went down by 3.5% in the study group and went up by 0.4% in the placebo group.3 There was no difference in fasting glucose.3
There were some adverse events such as nausea, extrapyramidal symptoms, insomnia, somnolence, and dry mouth.3 However, they were reported to be no significant differences. During the 12-week follow-up therapy, 6 patients were lost because of the adverse drug reaction.3 Regarding the study results, it was analyzed by intention to treat principles. Every...

Find Another Essay On Research Study on Metformin, a Drug and Its use for Antipsychotic Treatment

This is sample treatment plan and assessment based on a fictional case study

1031 words - 4 pages to develop a support network. Continual work on self- image, goal setting, and relationship issues is advised. A comprehensive exploration of suicidal fantasies is strongly recommended. A psychological assessment is also recommended to address any possible mood or anxiety disorders, with continual monitoring and adjustment as needed. Coping skills training and stress management activities are recommended. Arrangements have been made for client to begin outpatient treatment on Monday, May 16, 2005.

Crimes And Drug Use Essay

3005 words - 12 pages Crime and Drug Use The link between drug use and crime is not a new one. For more than twenty years, both the National Institute on Drug Abuse and the National Institute of Justice have funded many studies to try to better understand the connection. One such study was done in Baltimore on heroin users. This study found high rates of criminality among users during periods of active drug use, and much lower rates during periods of nonuse (Ball et

Sports and Drug Use

952 words - 4 pages reason. Major League Baseball did not ban andro despite a study that found its use to be hazardous. Certainly the regulations lack common sense. The drug itself is considered a controlled substance, but the drug is determined to be a food-related supplement. The Food and Drug Administration and the U.S. Congress need to come together and stop this controversy. Androstenedione has been tested at Harvard University, which has found that andro does

Athletes And Drug Use

2246 words - 9 pages . One reason is that new drugs keep coming on the market, and some turn out to be of help in giving athletes a competitive edge. Sports officials feel they have no choice but to try to combat drug use in sports with every legitimate weapon at their command. They are motivated in part by concern for athletes' well being. Most performance-enhancing agents have side effects that can pose an immediate or long-range threat to health. But the

A research paper on cocaine, and its effects on the user

1483 words - 6 pages way into other products like wine and the most famous of all, Coca Cola. Early production of Coca Cola contained 60mg of cocaine. Today, the popular soft drink still uses the leaves of the Coco Bush for flavor but the illicit drug has been removed ( resurrection of cocaine use as a recreational drug began in the 1960's, and was used mostly among the affluent because of its price. Movie stars, sport stars and the like give

Drug related crime: a distinction between crimes rooted in prohibition and crimes caused by drug use

2938 words - 12 pages society, 6th ed, prentice Hall, New York, 2000.Lucas T, Sociology of Deviance: SOC01123 Study Guide, Southern Cross University, Lismore, 2003.Makkai T, Drug Use Monitoring in Australia: 1999 Annual Report on Drug Use Among Adult Detainees, Australian Institute of Criminology, Research and Public Policy Series, No 26, Canberra, 2000.Manderson D, From Mr Sin to Mr Big: A History of Australian Drug Laws, Oxford University Press, Melbourne, 1993.Milne

Mental Illness and its Treatment

2230 words - 9 pages rare (Wahl 2003, 1594) . Examples of this from the study are cartoons parodying people with mental illness by showing them with weapons and hockey masks (Wahl 2003, 1596), a murder on one of the subways in New York with the murderer suffering mental illness whipping up media hysteria so much that a new law resulted forcing outpatients to receive psychiatric treatment(Wahl 2003, 1597) and the case of a suicide victims obituary unfairly highlighting

Professional Athletes and Drug Use

1842 words - 7 pages Professional Athletes and Drug Use This research paper is about athletes and their use of drugs. The drug that is most frequently used by athletes is alcohol. Most athletes who use drugs do not get the punishment that they deserve instead they receive punishment that is too lenient. The penalties for professional athletes who use drugs are too lenient, they should be more severe. Examples of drugs that are used by most

Drug Abuse and its dangers

877 words - 4 pages The subject of drug abuse can be difficult for most. Many people struggle with drug abuse and know someone that is fighting addiction or dependency. Many people who know someone try to help them but sometimes the user is afraid of withdrawals because they know that they have to go through stages that can be harmful or vehement. There are many places that can treat people for drug abuse and they can help them recover and change their way

A brief field study of the Vancouver(Canada) Landfill and its effects on the environment

661 words - 3 pages collection of leachate is pumped to the water treatment plant on Annacis Island. Routine water quality checks take place to make sure the leachate collection system is working properly.Landfill GasAnaerobic organisms are constantly eating the garbage at the landfill and they output methane and carbon dioxide as wastes. This methane, if left uncontrolled would be bad for the environment. Greenhouse gas emission is a major concern for the Vancouver

Discuss the use of poetic form and language and its effects in 'Ode on a grecian urn'

1533 words - 6 pages us to read through to the final couplet. The Urn is in the real world and will remain so after those who view it now are gone. There will be others in future. It is a part of life and yet the life carved upon it is unchanging. It is unaffected by the pain and time as the human condition will know it, but will be there for future generations and have something to say to its viewer.Although action is portrayed, the scenes on the urn are frozen in

Similar Essays

Effects On Drug Use For Teenagers

1124 words - 5 pages Drug use has been a major problem for many years. Many of the users are teenagers, experimenting with this temptation. Teenagers may often be tempted by friends, or being tempted by seeing other people using drugs. Drugs may feel, or be fun to use, but drugs might also have a major impact on someone’s life. Drugs can affect someone’s life by damaging their health. Using a drug can be very addictive, and that can lead to an overdose, or

A Medical Information Recommender System For Disease Prediction And Its Treatment

1834 words - 8 pages and breast cancer. They used dierent algorithms for predicting dierent diseases. III PROPOSED WORK In this paper, we are suggesting a medical information recommender system for disease prediction and its treatment. We have used a relative learning step on the proposed system. The other feature of this system will be its cure time prediction. Our system follows the procedure given in the owchart in Figure.1. Figure 1. Flow Chart A. Reading

Leukemia And Its Treatment Essay

840 words - 3 pages treatment for leukemia the one that you receive depends on what stage the cancer is in and what kind of leukemia you have. Chemotherapy is one form of treatment, patients who have chemotherapy take one or more anti-cancer drugs by mouth or intravenously, through a tube in one of the veins. Chemotherapy is given in cycles a treatment period followed by a recovery period, then another treatment period and so on. The drug enters the blood stream

“Development Of A Green Composite Based On Pla/Starch Blends And Blue Agave Fibres (Agave Tequilana Weber Var. Azul) For Its Use In Food Packaging

1407 words - 6 pages crisis. As oil prices raised, so did the interest and research of bio-based materials. New developments were result of this work; biodegradable films, sheets, and mould forming materials saw the light during the 1980’s. Plant based materials have become increasingly more popular (19). Looking at the tendency to use the highest percentage of renewable resources, green plastics seem to be a good option for its use in the food packaging industry. Many