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802 words - 4 pages

Atherosclerosis is a multiple factorial disease, which is the major underlying cause of various cardiovascular diseases including CAD, ischemic gangrene, abdominal aortic aneurysms, heart failure and stroke (Hansson et al., 2006). Worldwide it is the leading cause of morbidity and mortality, especially in developing countries where it is acting as a silent killer (WHO, 2005; Hansson et al., 2013). It was observed that Asian Indians have early onset of the disease as compare to whites, with present burden of 29.8 million people with coronary heart disease (Gupta, 2005; Yusuf et al., 2004). Extensive evidence in the literature supports the role of systematic and chronic inflammation in the pathophysiology of the disease since its inception onwards (Ross, 1993; Libby, 2005; Mallika et al., 2007). Monocyte-derived macrophages and T lymphocytes are the earliest and the most important cells that invade evolving lesions. These cells produce a wide array of soluble inflammatory mediators (cytokines, chemokines) that are critically important in the initiation and perpetuation of the disease.
Presently, conventional therapies employed in cardiovascular medicine and research focus on preventing the disease by modifying the conventional risk factors and by treating the clinical manifestations as inflammation and hypertension (Zhou et al., 2010). However, inspite of improved pharmacological, dietary and lifestyle approaches, reduction in CAD event rates has never surpassed beyond fifty percent (Gaede et al., 2008). Also in many cases, it has been observed that the clinical outcome or response to therapy is poorly linked to the signs and symptoms of the disease. Till date, no pollypill or a single drug exists in market that offers a reliable, specific and definitive cure and protection from the devasting effects of this disease. Therefore, it is logical to search for a remedy/natural compound that can protect against endothelial dysfunction, hypoglycemia, hyperlipidemia and immune imbalance.
Since ancient times, natural products are the major source of various therapeutic agents to cure various human diseases and disorders. Ayurveda, an old traditional form of medical practice in India, has produced many effective leads and contributed well for isolation and development of novel therapeutic compounds. Presently, it is estimated that in both developing and developed countries; about 70-80 percent of the world’s population is using alternative medicines for their primary health (WHO, 2008; Pandey et al., 2013). Recently, there is a reborn interest in the use of ayurvedic or traditional medicines for the prevention...

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