Scientific Criticism Of The Journal ‘Creation Of A Bacterial Cell Controlled By A Chemically Synthesized Genome’ By Gibson Et Al., Published In Science On The 2nd Of July 2010.

1535 words - 6 pages

LIN1603 Assignment
Critical Evaluation of a Scientific PaperIntroductionThe paper, chosen for critique is 'Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome' by Gibson et al., published in Science on the 2nd of July 2010.1Summary of PaperThe paper reports the experiment which was carried out by Craig Venter and his research team. Synthesis of the genome of a bacterial cell and the transplantation of such genome into another bacterial cell, allowed the research team to finally create a bacterial cell that is controlled by a genome which is chemically synthesized.This synthesized bacterial cell is unique and somewhat revolutionary since it seems to be controlled by synthetic chromosomes. In addition, such synthesis of bacterial cell which uses chemically synthesized genome may be important for future applications such as in the case of vaccine and food ingredient production.Such synthesis was made possible by introducing DNA sequences into the original genome, making it distinctive and the first of its own. DNA-repair enzymes were extracted from yeast cells and used in order to link up short DNA sequences together. Upon synthesis of the Mycoplasma mycoides genome, it was inserted into a cell of different bacterial species, which however had similar physical attributes.Much of the mechanism and the steps involved in such synthesis still need to be comprehended. Further attempts at improving the procedure need to be made and better understanding is still required, such that the synthesized bacteria are manipulated according to need.Critical Evaluation of PaperThe paper by Gibson et al., is revolutionary in the sense that the synthesis of synthetic genome which acts as the principle controlling factor of a bacterial cell, is unique and has never been done before. This paper proves its significance and importance since this synthesis may also be applied and implemented in other fields of study. The method may be developed and understood much better: "We need to improve methods for extracting". This might weaken the significance of the paper, however the scientific standard is still high due to the fact that such research is still in its early stages and the results seem to have been treated in great detail. In addition the paper denotes room for improvement and further study. Claiming that this research is the first of its kind may be somewhat incorrect since this experiment was based on previous studies, carried out by the same research team: "Our interest in synthesis […] grew out of our efforts over the past 15 years".1 All in all, the paper deems itself reliable and suitable for publication. Being backed up by a renowned magazine as is Science, indicates a promising and dependable journal.The journal is to some extent formal, as indicative of by the type of language used. Furthermore, scientific terms are used as is expected in a scientific paper. This may however be problematic for someone who is not scientifically...

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