Sickle Cell Anemia Essay

637 words - 3 pages

I think a very good report Well done...your best work yet!Sickle Cell AnemiaSickle Cell Anemia is the most common hematologic hereditary disorder knowtoman. It is a condition where the red blood cells (RBC) sometimes assume astrange,sickle©like shape. Observations date back to Herrick in 1910, but themolecularera for the study of Sickle Cell Anemia did not begin until the identificationofHemoglobin S (Hb S), by Linus Pauling in 1949. It is a world©healthproblempredominantly affecting Negroes in the Untied States and Africa, andsometimesLatins. 50% of those with Sickle Cell Anemia die before age 20, and most donotlive to reach age 40.Normal Red Blood Cells are shaped similar to donuts, and pass easily throughtheblood stream to carry Oxygen to ALL parts of the body. Sickle cells, because ofthere oddshape, do not easily pass through the blood vessels and tend to clog them,because of this,internal organs may not receive enough oxygen.I in 10 African©Americans carry the gene, and about 1 in 400African©Americanchildren carry Sickle Cell Anemia.If a person is hybrid for the disease, they are said to have the sickle cell'trait'.Their cells can be made to sickle in a test tube, and under extremeconditions of exercise,and at high altitudes. This is rare and seldom serious,most people with the trait live full,normal lives. The trait can never turn intothe anemia.About 50% of the children of to parents who both have the trait will also havethetrait. About 25% will be born with the anemia, and about 25% will not beaffected byether one.o o|/ |// /T T©©©+©©©©©+©©© T=Trait| | | | A=Anemiao o o o N=Not AffectedX X X XT T A NSickle Cell Anemia affects the hemoglobin, which is theoxygen©carryingmolecule in the RBC. A molecule of haemoglobin is composed of twopairs ofpolypeptide chins, with a total of 574 amino acids. It has two alpha chains,eachwith 141 amino acids, and two beta chains, each with 146 amino acids. Theonlydifference between Hemoglobin S,...

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