Signs And Symptoms Of Gigantism Essay

1154 words - 5 pages

Introduction
Biology mainly concentrates on the study of life and any other factors that affect it positively or negatively. The study of biology is further sub-divided into sections and the most important being genetics that studies the genetically composition and effects to human life. For instance, gigantism which is an abnormal growth caused by the excess hormone growth at childhood before the bone plates closes. Though gigantism is rare, it is caused due to some factors among them; Noncancerous tumor of the pituitary gland, Neurofibromatosis, McCune-Albright Syndrome (MAS), Carney complex and Multiple Endocrine Neoplasia type 1(MEN-1). This abnormal growth occurs mainly before the closure of the bone growth plate. In any case the growth hormone occurs after the normal growth has stopped then the condition is known as acromegaly (Gina Gould ‘et al’, 2004).
There are several symptoms that can be used to detect the condition. It leads to the growth of the child in muscles, height and organs and hence the child being larger or bigger than his or her age. Other symptoms include; irregular periods, release of breast milk, weakness, increased sweating, thickening of the facial features, large hands and feet with thick fingers and toes, headache, delayed puberty, frontal bossing and a prominent jaw and double vision or difficulty with side vision. There are also some signs and test that can validate gigantism. The tests are; increased Insulin Growth Factor-I (IGF-1) levels, CT or MRI scan of the head showing pituitary tumor, high prolactin levels and failure to suppress serum Growth Hormone (GH) levels after an oral glucose challenge (maximum 75g). Damage to the pituitary generally leads to low levels of other hormones among them; thyroid hormone, cortisol, testosterone in boys and estradiol in girls. Gigantism has several treatment measures medically approved which are; surgery, medication, dopamine agonists and radiation (Gina Gould ‘et al’, 2004).
How growth hormone regulate various body functions in adults.
The growth hormones mainly regulate the body functions via feedback loops. The process is a two way mode of communication whereby the target organ releases molecules that regulate the endocrine. The feedback loops are mainly concerned with the maintenance of the hormonal concentration within range. Endocrine disorder can be classified based on the underproduction or excess production of the hormone (Medical Discoveries, 2011).
The growth hormone is mainly produced from the brain and it stimulates insulin-like factor (IGF-1). It also mediates the actions of HGH which regulates variety of biological activities including cellular division, development of the body, overall growth and metabolism. It also plays an important role in body composition, bone and muscle strength. The growth hormones play an important role in adults because growth factors have an important role in longevity determination and aging. The growth hormone reverses...

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