This website uses cookies to ensure you have the best experience. Learn more

The Causes And Consequences Of Metabolic Inflexibility

1272 words - 5 pages

Metabolic flexibility is the ability to adjust and modify fuel oxidation depending on the fuel that is currently available. This capacity to adapt requires an ability to use lipid and carbohydrate fuels properly and the ability to efficiently switch between them, depending on fuel availability (Kelley et al., 2002). On the other hand, metabolic inflexibility is defined as the inability to change fuel oxidation in response to variations in macronutrient availability (Koves et al., 2008). There are opposing views among researchers on which types of diets and other nutritional factors can affect the onset of metabolic inflexibility and its results, such as insulin resistance. Some studies have supported the hypothesis that insulin resistance develops from metabolic inflexibility due to decreased fat oxidation and accumulation of cytosolic lipid molecules (Koves et al., 2008). However, increasing amounts of recent studies have presented observations that point to excessive, not diminished, incomplete beta-oxidation is the true cause of obesity-related insulin resistance in skeletal muscle (Koves et al., 2008). In addition, Koves et al. (2008) also revealed that insulin resistance is related to metabolic inflexibility during the fasted-to-fed transition as well as the depletion of organic acid intermediates from the citric acid cycle (Koves et al., 2008). Despite disagreeing on the precise cause of insulin resistance, all of the published research agrees on one central theme: it is imperative to remain metabolically flexible in order to avoid the numerous, and potentially disastrous, consequences associated with metabolic inflexibility.
As previously described, metabolic inflexibility is the inability to appropriately switch back and forth between fuels depending on their availability in the fed and fasted states. This inflexibility can result in weight gain, which in turn will eventually lead to obesity and other weight-related health issues. Furthermore, insulin resistance can develop and ultimately advance into type II diabetes. Another adverse effect of metabolic inflexibility is decreased expression of OXPHOS genes (Sparks et al., 2005). As a result, the occurrence of fat oxidation will increase while the rate of carbohydrate oxidation will decrease. The mitochondrial overload that is produced from a high-fat diet will result in incomplete beta-oxidation of fatty acids. The organism’s mitochondria might even double in size in an effort to try to compensate for this overload (Sparks et al., 2007). Obesity-related glucose intolerance might also arise from metabolic overload of the mitochondria in skeletal muscle due to a high-fat diet (Koves et al., 2005).
Similarly, Fex et al. (2007) found that a high fat diet resulted in insulin resistance as well as glucose intolerance, two hallmark issues associated with metabolic inflexibility. Further analysis of the high-fat diet mice revealed an accumulation of lipid droplets in beta cells in addition to...

Find Another Essay On The Causes and Consequences of Metabolic Inflexibility

The Causes and Consequences of Genocide

1061 words - 4 pages that a society with people that are all identical would be boring. Genocide is a dreadful thing for any country to deal with. Overall, from the points discussed, genocide has way more negative consequences than positives. Genocide causes a lack of diversity which can hurt the economy more than advance it because diversity encourages growth and development. If everyone is similar, there's not much room for the economy to change or grow. It causes

The Causes and Consequences of the French and Indian War

647 words - 3 pages From One War to AnotherThe French and Indian war, a war that had assembled the largest number of troops ever, was caused by more than a hundred years of rivalry between the two countries, had several consequences on the British Empire, and impacted the colonies greatly. When the fire of the French and Indian war was blown out, another match was dropped, starting another war.The main causes of the French and Indian war also known as the Seven

What were the causes and consequences of the Mexican War?

642 words - 3 pages , and to offer the U.S. government's assumption of liability for the claims of U.S. citizens in return for boundary adjustments. When Mexico declined to negotiate, the United States prepared to take by force what it could not achieve by diplomacy. The war between the United States and Mexico had two basic causes, Manifest destiny and the U.S. annexation of Texas, which led to further conflict between the North and the South and indirectly caused the

The Causes And Consequences Of The General Strike In 1926

1340 words - 5 pages The Causes And Consequences Of The General Strike In 1926 For a brief period after the First World War, Britain faced an economic boom. Workers were in a strong position and businesses were optimistic, believing that world demand for British goods would increase and trading would return to the success it had prior to the war. However, in 1920, Britain experienced their worst economic slump in history. This was caused by

The Causes an Consequences of Crime and Punishment

2058 words - 9 pages this is what happens to the main character of the book, Raskolnikov. He is given many chances to do the right thing and not sin, yet the devil still provides even more temptations, and gets Raskolnikov to fall into the trap of murder. Yet God does still give you chances for forgiveness and wants you to reject your sin. The devil works in any way he can to get men to sin, but God will send a way to get you to forgive your sins and come back to him

Causes of Brain Trauma and their Consequences

1624 words - 7 pages YEAR : 2 LECTURER’S COMMENTS: ………………………………………………………………………………………………… ……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………… Question: (A) Explain the causes of brain trauma and their consequences. According to Gregory (2001) the brain is defined as the control centre for the most complex organ of the human body. Traumatic brain injury is defined as a result of the application of either

Causes and Consequences of Marital Breakdown

884 words - 4 pages Helga Kissová, 3ESANThe Causes and Consequences of Marital BreakdownMarriage is a complex interpersonal relationship. Among the reasons for marriage are emotional, financial, spiritual, and religious ones. In some religions marriage is considered to be a sacred bond between a man and a woman and to break it up is viewed as a blasphemous act. However, nowadays divorce is becoming an everyday process and people do not even blink if a

Causes and Consequences of Alcohol Prohibition

1570 words - 6 pages structure of American policy making, especially liquor policies. Throughout US history, states have regulated alcohol consumption in many different ways such as liquor licensing, local options, excise taxation, distribution and finally, statutory prohibition. Indeed, according to Shrad (2007), the prohibition causes lie within american policy experimenting just as nine other North American and European countries did. (Schrad, 2007) Consequences

Causes and Consequences of Operation Barbarossa

2296 words - 9 pages Causes and Consequences of Operation Barbarossa On June 22nd 1941, German forces crossed the Russian frontier and began to fight their way into Soviet territory. Operation Barbarossa, Hitler's codename for the attack on Russia, had begun. In this essay I am going to describe the causes, events and consequences of Operation Barbarossa. What happened when the 'unbeatable' Hitler and Germany met the sheer determination and

Causes And Consequences Of WWII 1935-1945

1280 words - 5 pages Darren Le.Thu, 20th March 2014.Causes And Consequences Of WWII 1935-1945A, Why was Germany so successful in the European War up to the start of Operation Barbarossa?There are many reasons for Germany's early successful in the European War up to the start of Operation Barbarossa. For one good thing, their army was bigger and another one has the most modern military in the world in 1939. While most of European were still using biplane, and tank

Pilot fatigue The Causes, Effects and Consequences

10532 words - 42 pages intended to reveal the potential consequences of fatigue and how it relates to pilots of aircrafts, I believe that it is important for you, the reader, to better understand how fatigue transcends all aspects of the transportation industry. There have been countless other incidents and accidents in other sectors, within the transportation field and outside of it, whose causes have been linked directly, or at least in part, to fatigue. It is

Similar Essays

Causes And Symptoms Of Metabolic Syndrome

1369 words - 6 pages the causes of Metabolic syndrome varies from a varieties of factors but the main issues starts with being things we as individuals can control such as obesity, being overweight, an inactive lifestyle, not eating right, healthy foods or over eating and insulin resistance. Some factors we aren’t able to control that can lead to this epidemic are becoming older, genetics such as your ethnicity and or family history which may play a role in causing

Causes And Consequences Of The Reformation

1039 words - 4 pages Causes and Consequences of the ReformationThere were several causes of the Reformation. Some of them were short-term causes and others were long-term causes. One of the long-term causes of the Reformation was that many people thought that the Church was not following the Bible. For example, many people were unhappy with the idea of indulgences. Indulgences were gifts that people gave to the Church so their sins would be forgiven. In 1517 Luther

The Causes And Consequences Of Global Warming

859 words - 3 pages hurricanes, and melting of ice-burgs have been increasing. Many scientists have agreed that that global warming is in fact still occurring as we speak. In the article "Global Warming: Confronting the Realities of Climate Change” it states that the signs are clear. The earth’s temperature has increased over the years. It has been shown and proven that global warming is still in effect because the consequences of this problem are still increasing

The Causes And Consequences Of Elder Abuse

1755 words - 7 pages This essay will begin by giving a definition of elder abuse and it will then go on to briefly explain elder abuse. It will then move on to discuss the causes and consequences of elder abuse. It will then outline the ways in which policy and practice has responded to the problem of elder abuse since the protection of our future: Report of the working group on elder abuse was published in 2002. It will then conclude by evaluating these responses