This investigation was undertaken to examine the role of essential amino acids, micronutrients and antioxidant status in alcoholic and tropical chronic pancreatitis and to compare with healthy controls. A further goal is to estimate serum rhodanese, thiocyanate and urinary inorganic sulfate/cratinine ratio as a measure of detoxification of cyanogens.
Chronic pancreatitis is an inflammatory disease associated with irreversible exocrine insufficiency, which in due course may cause fibrosis and diabetes mellitus and with significantly increased risk of developing pancreatic cancer.
Chronic pancreatitis has been on the clinical map for more than 200 years. In 1788 Cawley (Cawley T, 1788) described a patient with calcific chronic pancreatitis. The classification of chronic pancreatitis as a separate disease was reported in 1946 by Comfort et al (Comfort M et al, 1946) published their work on “chronic relapsing pancreatitis” and provided for the first time a thorough analysis of its clinical features, etiological factors, and pathology.
In 1878 Friedreich (Friedreich N et al, 1878) described pancreatitis in relation with alcohol. More than 100 years ago, it was proposed that pancreatitis is essentially a disease in which the pancreas is auto-digested.
• Prevalence and epidemiology
The prevalence of chronic pancreatitis in autopsy materials ranges from 0.04 to 5 % (Sarles H, 1973; Skyhoj Olsen T, 1978). Epidemiologic studies based on clinical data are few. The prospective study conducted on the incidence and prevalence of chronic pancreatitis in Copenhangen, Denmark in 1978 to 1979 showed 8.2 new cases /100,000 inhabitants /year and a prevalence of 26.4 cases/ 100,000 inhabitants (Copenhagen Pancreatic Study, 1981). Study conducted in Japan showed incidence and prevalence of CP much higher than those from western countries (i.e. 12.4/100,000 and 45.4/100,000 population respectively) (Lin Y et al, 2000b)
Recent population-based epidemiological studies on chronic pancreatitis are sparse and time trends in incidence and prevalence rates are often lacking. A few reports show a crude incidence rate of chronic pancreatitis ranging from 5.9 to 7.9 per 100,000 inhabitants and one study including all age groups–has reported a crude prevalence rate of 26.4 per 100,000 inhabitants (Dite P, 2001; Lankisch PG, 2002; Levy P, 2006). Recent study from Denmark reported that prevalence of CP increased from 11.7 per 100,000 person years in 1980–1984 to 17.0 per 100,000 in 2000–2004 (Joergensen M et al, 2010).
The epidemiologic studies clearly demonstrate that there is enormous...