The Role Of Perivascular Macrophages In Breast Cancer Metastasis

2675 words - 11 pages

The role of perivascular macrophages in breast cancer metastasis.
1. SPECIFIC AIMS
The solid tumor microenvironment is comprised of both malignant and non-malignant cells and an increasing body of evidence suggests that the fate of malignant cells can potentially be altered by the behavior of the surrounding non-malignant cells. It is becoming increasingly evident that the modulation of tumor microenvironment has an important role to play in tumors displaying their full neoplastic potential and thus targeting the surrounding non-malignant cells particularly the immune cells as potential therapeutic targets is not unheard of. In the last decade the general concept for tumour development has ...view middle of the document...

Previous studies have implicated PVMs in tumour cell invasion into blood vessels3, but this process is far from being understood. In this project, we aim to dissect the precise role of PVM in hematogenic and lymphatic spread of tumor cells. We expect to obtain novel insights into the function of these thus-far underappreciated cell populations in breast cancer cell biology.

OBJECTIVE: Owing to the strategic location of perivascular macrophages adjacent to post capillary venules and lymphatics which interestingly are also the routes for tumor cell extravasation and the availability of the DPE-GFP mice unique to our group we are in an ideal position to study the role of this macrophage subset during tumor progression and metastasis. The aim of this application is to study the physical and biochemical cues that aid the breast cancer cell dissemination and extravasation.
Hypothesis: PVM facilitate the intravasation of breast cancer cells cells into the blood vessels and lymphatics
Aim 1. To dissect the role of PVM in breast cancer growth and metastasis.
Aim 2. To study the process of neoangiogenesis and lymphangiogenesis during breast cancer development.
Aim 3. To generate a novel transgenic mouse model for the selective depletion of PVM and to study the effect of PVM depletion on breast cancer development and metastasis.

BACKGROUND

BREAST CANCER: Breast cancer continues to be one of the leading causes of death in women worldwide. It is the second most common cancer after lung cancer and fifth most common cause of cancer death thus suggesting that the global burden of this life threatening disease is huge. In Australia, breast cancer accounts for 28% of deaths in women (Cancer Council Australia). In 2013 alone, over 13,000 Australian people were diagnosed with breast cancer. The fatalities associated with breast cancer are usually not caused by the primary tumour itself but rather by secondary daughter (metastatic) cancers, most commonly observed in lymph nodes, lungs, bones, brain and liver. Although there are strategies for treating primary cancers, in particular surgical resection, metastatic cancers are much more difficult to treat due to development of resistance to drug therapy. Therefore, we must strive to understand the basic process of breast cancer metastasis if we are to improve the available therapies and to identify novel drug targets. In this application, we will exploit state-of-the-art imaging technology in combination with genetically engineered reporter mice unique to our group to interrogate the dynamics and mechanisms of breast cancer cell metastasis in live tissue. This will enable us to generate entirely new insight into how cancer cells spread through the organism. We anticipate not only generating a better understanding of the metastatic process, but also identifying novel therapeutic targets for this deadly disease.

ROLE OF MACROPHAGES IN BREAST CANCER: Macrophages are generally defined as the sentinel cells of the...

Find Another Essay On The role of Perivascular Macrophages in Breast Cancer Metastasis

The Issues of Breast Cancer in Nigeria

1616 words - 6 pages responsible for about 10% of breast cancer deaths. At this stage, the health sector comes in to play a great role. Doctors should try to emphasize the importance of exercise, healthy eating and moderate alcohol intake to all patients at hospitals. An article presented online by the WHO states: As part of the ongoing Black Women's Health Study, a recent research was particularly focused on foods that help lower the risk of estrogen receptor-negative (ER

Overview of the Treatment of Breast Cancer

2269 words - 9 pages survivors in the United States (American Cancer Society, 2011). Therefore, preventing long-term health-related issues are of a particular concern for patients who survive for many years, especially after breast cancer diagnosis. Literature Review The exhausting treatments that cancer patients endure can often result in a significant decrease in their quality of life. The role of physical activity in enhancing longevity in cancer survivors has

The Risk Factors of Breast Cancer

1557 words - 6 pages their family cancer history. For instance, genetics can play a role in developing this disease, as well as some inherited genes. Additionally, having a family history of breast cancer can double the risk of development. About five to 10% of the diagnoses from this disease are hereditary (Port, 2013). The mother’s family history, as well as, the father’s family history count the same. Specifically, both sides of the family should be looked at with

Cancer Cell Metastasis and How Cells Diffuse Into Diverse Parts of the Body

947 words - 4 pages activity of tumor cells and how they evade has therefore been to study how signals can direct the cells to different parts of the body. In normal circumstances, cells are able to bind to one another as well as form an extracellular matrix. Different types of adhesion can function as a critical role in metastasis and tissue invasion. It is thought that cell-to-cell adhesion, which is common in normal tissue, is not a characteristic of cancer cells.Tumor

The Most Common Cancer in the UK: Breast Cancer

2309 words - 9 pages Being the most common cancer in the UK, breast cancer affects about 48,000 women a year, it affects mostly women over the age of 50, however younger women and in some cases even men can be affected by the disease. Multidisciplinary team or MDT are there for cancer patients to provide them with the best possible care and treatment for each individual patient. The MDT team consists of a specialist cancer surgeon, an oncologist, a radiologist, a

The Use of Telomerase in Diagnosis, Prognosis, and Treatment of Cancer: With a Special Look at Breast Cancer

2613 words - 10 pages . There are actually many potential blockers, but only a few have all the desired characteristics such as being harmless to the cell and completely inactivating telomerase. The leading inhibitor is called AZT and has been successful at stopping breast cancer cell growth but its entire function remains not fully understood (Herbert 2001).Telomerase plays a vital role in cell biology and acts as great mechanism of avoiding telomere shortening. For

One of the Most Well-Known Cancers in Today's Society, Breast Cancer

1839 words - 8 pages Breast Cancer is one of the most well-known cancers in today’s society. Or is it? What does society know about breast cancer other than it obviously is cancer of the breast? Breast cancer is very well advertised with the pink ribbons, the commercials and advertisements, the Breast Cancer walks, and the promotional information given out regarding mammograms. In today’s world there are several cancers, but breast cancer is very prevalent among

The Benefits of Medical Marijuana in Breast Cancer Patients - Resources for Research Library Course - Research Paper

1612 words - 7 pages Thesis: Why is it that in 2017 an estimated 255,180 women are expected to be diagnosed with invasive breast cancer but that medical marijuana is not widely considered an important ally in the treatment of those patients? Marijuana has been used for hundreds of years and is generally considered a safe drug, despite its classification as a Class 1 drug in the United States, the same classification as heroin and cocaine. In the 28 states where it

Breast Cancer- Awareness in Females

1721 words - 7 pages metastasis together, and based on the answer given the cancer is placed in five stages; stage 0, stage I, stage II, stage III, and stage IV (Mandal 2013; American Cancer Society n.d.; Office of Womens Health n.d.). Stage 0 contains breast cancers that are usually noninvasive. Stage I is divided into two sections IA and IB; cancers classified here are either smaller than two centimeters or have small clusters of cancerous cell in lymph nodes, no

Breast Cancer- Awareness in Females

2263 words - 10 pages Introduction- “What is breast cancer? How does it relate to women today? When is it appropriate to talk to a doctor?” These questions are all questions that women today ask each other, various health professionals, and doctors. As the most recognized form of cancer in the United States breast cancer affects so many women today. It is a disease that does not distinguish between race, religion and social status. In more recent cases, many young

EXPRESSION OF ANDROGEN RECEPTOR IN THAI BREAST CANCER PATIENTS

2175 words - 9 pages by de Matteis, et al. and Scholl A. (41, 42) or treat skin metastasis by Battelli, et al.(43). Androgen may be a new target for breast cancer treatment on the future (44). Conclusion The prevalence of androgen receptors in Thai breast cancer patients was 80.00% and less expression in triple negative breast cancer patients (33.33%). The androgen may be a new target therapy for Thai breast cancer patients who had highly expressed of androgen

Similar Essays

Elucidating The Role Of Adhesion Factors In Circulating Tumor Cell Clustering For Breast Cancer Metastasis And Venous Thromboembolism

667 words - 3 pages biomarkers to treat metastatic breast cancer. B. Rationale: We seek to study the process of microtubule nucleation in various breast tumor cell lines of diverse metastatic potential and understand the role of abnormal microtubule nucleation in breast cancer metastasis. Preliminary studies from our lab have shown a dissimilar staining pattern by immunofluorescence in the major microtubule nucleating protein, γ-tubulin, as compared with normal

Molecular Regulation Of Bone Marrow Metastasis In Prostate And Breast Cancer

2762 words - 12 pages patients without bone metastases or control group (87). These results can highlight the role of miR-10b as a biomarker for identification of bone metastatic breast cancer or as a marker of prognosis in breast cancer, which requires further studies. The increased level of soluble intracellular adhesion molecule (sICAM1) as well as OCL microRNAs-16 and -378 during OCL differentiation is associated with bone metastasis (88). MiR-335 is a metastasis

Role Of Social Support In Breast Cancer

2243 words - 9 pages Following skin cancer, breast cancer is the most common cancer among women, as approximately 12% of women will develop invasive breast cancer throughout their lifetime (Ma, Jemal 2013). After being diagnosed with breast cancer, women face major psychological and social challenges to coping with the disease. Many studies have examined the role of social support in cancer progression. It is commonly found that having a strong social support system

"The Role Of The Media In The Public Understanding Of Health Issues" Breast Cancer & Silicone Implants

2020 words - 8 pages In this paper, the writer shall debate the issue of whether or not the media play a significant role, in contributing to the publics' education of breast and other cancers, due to silicone gel breast implants, and the strategies used, if any, to promote public awareness. The reason for the writer's interest in this subject is that writer had silicone breast implants, which leaked, whereupon a second operation was undergone to remove them. The