Weight Loss with Phen/Fen and Redux
History of Weight Loss
Since the beginning of time, weight loss has been a concern for people throughout the world. In the Nineties, it has become the focus of numerous advertisements, articles, and media scams. Infomercials selling everything from exercise equipment to magical creams promising results of cellulite-free thighs are plastered across late-night television in perfect view for anyone. Along with all of this, diet pills once again became the fad in 1994 with phen/fen. This was the first time since the 1960s. Then, in 1996 Redux hit the market (http://www.mesomorphosis.com/obesityclinics.htm). The advertisements for these pills were aimed towards those people who were obese and wanted to lose weight and get results. What is remarkable are the differences that range among these ads. Some promised results without the dangers of the side effects, while others offered detailed information about the possible risks involved in using the medications. This leads to a confusing situation that leaves people wondering what to believe. Further examination in to this topic shows startling evidence that Fenfluramine and Dexfenfluramine can cause serious health problems which can be fatal. Looking at all of the different and confounding data, people are sure to be confused about what is really true about these diet pills.
The Drugs Defined
Before understanding the claims that people have made about these drugs, the drugs themselves must be defined in terms of what the drugs are and how they work. The phen/fen diet pill combination is composed of two drugs, neither of which are new. Phentermine (phen) and Fenfluramine (fen) have both been prescribed separately by doctors for many years and are FDA approved (http://www.netek.com/weightwise/phen.htm). Both are anorexics, which help inhibit appetite in two different ways. Phentermine is a stimulant that acts through noradrenergic and dopaminergic pathways. This results in decreased appetite, which in turn leads to less eating. Fenfluramine acts through serotonergic mechanisms that induce increased satiety (http://www.weight.com/phenfen.html).
Redux, or Dexfenfluramine, is the first drug in more than twenty years that the FDA has approved for weight loss. It is a serotonin reuptake inhibitor and releasing agent (http://www.netek.com/weightwise/phen.htm). This anorexic drug, which has been used for years in Europe, causes the release of serotonin in brain cells. The actual action of serotonin is uncertain, but increased levels appear to stimulate the part of the brain which controls mood, sleep, and body temperature among other functions (http://www.weight.com/Dexfenfluramine.html). A Phen/Fen Study on the Internet
When looking at the effectiveness of phen/fen in losing weight, one study done by Michael Weintraub provides considerable information. The study took place over 210 weeks. The patients ranged in age from 18 to 60 and weighed between...